A5036793376- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- HIV Research and Treatment
- Hepatitis Viruses Studies and Epidemiology
- MicroRNA in disease regulation
- Complementary and Alternative Medicine Studies
- Respiratory viral infections research
- Influenza Virus Research Studies
- RNA Interference and Gene Delivery
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- interferon and immune responses
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
- Viral Infections and Vectors
- Phytochemicals and Medicinal Plants
- Tea Polyphenols and Effects
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Mosquito-borne diseases and control
- HIV/AIDS Research and Interventions
- Virus-based gene therapy research
- Piperaceae Chemical and Biological Studies
- Herbal Medicine Research Studies
Academy of Scientific and Innovative Research
2024-2025
Government of West Bengal
2022-2025
National AIDS Research Institute
2020-2024
ICMR-National Institute of Virology
2024
Indian Council of Medical Research
2020-2024
Central Council for Research in Homoeopathy
2022-2024
Ministry of Health and Family Welfare
2023
Bharati Vidyapeeth Deemed University
2019-2021
National Institute of Cholera and Enteric Diseases
2009-2021
National Institute for Research in Reproductive Health
2014-2015
ABSTRACT Hepatitis C virus (HCV)-mediated chronic liver disease is a global health problem, and inflammation believed to be an important player in pathogenesis. HCV infection often leads severe fibrosis/cirrhosis hepatocellular carcinoma, although the mechanisms for advancement of are not fully understood. The proinflammatory cytokines interleukin-1β (IL-1β) IL-18 have critical roles establishment inflammation. In this study, we examined induction IL-1β/IL-18 secretion following infection....
Following virus infection, one of the cellular responses to limit spread is induction apoptosis. In present study, we report role rotavirus nonstructural protein 1 (NSP1) in regulating apoptosis by activating prosurvival pathways such as phosphatidylinositol 3-kinase (PI3K)/Akt and NF-κB (nuclear factor κB) during early hours infections (2 8 hpi). The NSP1 mutant strain A5-16 induces weak transient activation Akt (protein kinase B) p65 compared isogenic wild-type A5-13 MA104 or HT29 cells....
Hepatitis C virus (HCV) is a serious global health problem and establishes chronic infection in significant number of infected humans worldwide. Interferon (IFN) IFN-stimulated genes (ISGs) are amplified during HCV but fail to eliminate from the liver large patients, mechanism not fully understood. MicroRNAs (miRNAs) have been implicated control many biological processes, including IFN signaling. To gain more insights into role cellular miRNAs possible countermeasures for suppression host...
Abstract Antiretroviral therapy is the only treatment option for HIV-infected patients; however, it has certain drawbacks in terms of developing multiple toxic side effects. Thus, there a continuous need to explore safe and efficacious anti-retroviral agents. Carica papaya Linn Psidium guajava are known their various biological activities. In this study, we characterized bioactive fractions methanolic leaves extract from both plants using High-resolution electrospray ionization mass...
ABSTRACT Hepatitis C virus (HCV)-induced chronic liver disease is one of the leading causes hepatocellular carcinoma (HCC). The molecular events to HCC following HCV infection remain poorly defined. MicroRNAs (miRNAs) have been implicated in control many biological processes, and their deregulation associated with different viral infections. In this study, we observed that hepatocytes transcriptionally downregulates miR-181c expression by modulating CCAAT/enhancer binding protein β...
Highlights•Diosgenin was extracted from the leaves of Helicteres isora Linn and subjected to comprehensive characterization.•Leaves extract H. characterized diosgenin exhibited anti-HIV activity against two different subtypes HIV–1 strains.•In silico in vitro assays demonstrated inhibition HIV-1 replication by targeting Integrase Reverse Transcriptase.AbstractBackgroundDiosgenin, an essential sapogenin steroid with significant biological implications, is composed a hydrophilic sugar moiety...
Antiretroviral therapy is the single existing for patients infected with HIV; however, it has drawbacks in terms of toxicity and resistance. Thus, there a continuous need to explore safe efficacious anti-retroviral agents. C-Phycocyanin (C-PC) phycobiliprotein, which been known various biological properties; its effect on HIV-1 replication needs revelation. This study aimed identify inhibitory effects C-PC using vitro silico approaches assess role generation mitochondrial reactive oxygen...
Development and characterization of LAM DTG loaded liposomes conjugated anti-CD4 antibody peptide dendrimer (PD2) to improve the therapeutic efficacy achieve targeted treatment for HIV infection. A 2-level full factorial design was used optimize preparation dual drug liposomes. Optimized ligand were assessed their cytotoxicity cell internalization on TZM-bl cells. Anti-HIV efficiency screened inhibitory potential in cells activities confirmed using Peripheral Blood Mononuclear Cells (PBMCs)....
Rotavirus (RV) being the major diarrhoegenic virus causes around 527000 children death (<5years age) worldwide. In cellular environment, viruses constantly adapt and modulate to survive replicate while host cell also responds combat situation this results in differential regulation of proteins. To identify induced expression proteins, 2D-DIGE (Two-dimensional Difference Gel Electrophoresis) based proteomics was used. For this, HT-29 cells were infected with RV strain SA11 for 0 hours, 3...