A5015077681- Fibromyalgia and Chronic Fatigue Syndrome Research
- Stress Responses and Cortisol
- Health, psychology, and well-being
- RNA Research and Splicing
- Plant Disease Resistance and Genetics
- Long-Term Effects of COVID-19
- Multiple Sclerosis Research Studies
- Spinal Cord Injury Research
- Child and Adolescent Psychosocial and Emotional Development
- Stroke Rehabilitation and Recovery
- Adrenal Hormones and Disorders
- Olfactory and Sensory Function Studies
- COVID-19 Clinical Research Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Phytoestrogen effects and research
- Palliative Care and End-of-Life Issues
- Health Systems, Economic Evaluations, Quality of Life
- Child Abuse and Trauma
- Tryptophan and brain disorders
- Intensive Care Unit Cognitive Disorders
- Omental and Epiploic Conditions
- Marriage and Sexual Relationships
- Intelligent Tutoring Systems and Adaptive Learning
- Patient-Provider Communication in Healthcare
- Fungal and yeast genetics research
Texas A&M University
2021-2024
Texas College
2022
Mayo Clinic
2021
WinnMed
2021
Bryan College
2021
Mitchell Institute
2019
DePaul University
2009-2018
The University of Texas at Austin
2014-2016
Northwestern University
2016
Brigham Young University
1985-1987
The burden of senescent cells (SnCs), which do not divide but are metabolically active and resistant to death by apoptosis, is increased in older adults those with chronic diseases. These individuals also at the greatest risk for morbidity mortality from SARS-CoV-2 infection. complications include cytokine storm multiorgan failure mediated same factors as often produced SnCs through their senescence-associated secretory phenotype (SASP). SASP can be amplified infection-related...
Co-transcriptional splicing takes place in the context of a highly dynamic chromatin architecture, yet role restructuring coordinating transcription with RNA has not been fully resolved. To further define contribution histone modifications to pre-mRNA Saccharomyces cerevisiae, we probed library point mutants using reporter monitor splicing. We found that mutation H3 lysine 36 (H3K36) – residue methylated by Set2 during elongation exhibited phenotypes similar those mutants. identified genetic...
Hypocortisolism has been reported in chronic fatigue syndrome (CFS), with the significance of this finding to disease etiology unclear. This study examined cortisol levels and their relationships symptoms a group 108 individuals CFS. CFS included fatigue, pain, sleep difficulties, neurocognitive functioning, psychiatric status. Alterations were by calculation mean daily cortisol, while temporal variation function was means regression slope. Additionally, deviation from expected diurnal...
Objective: Psychological variables such as perceived stress appear to play a role in symptom onset or disease exacerbation multiple sclerosis (MS). The authors sought determine if is indeed associated with the expression of pro-inflammatory cytokines and symptoms individuals MS. To do so, examined relationships among symptomatology, stress, cytokine production from peripheral blood mononuclear cells 42 outpatients MS 36 normative controls. Method: drew all subjects prior completion series...
Objectives Studies have demonstrated immune dysfunction in adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); however, evidence is varied. The current study used network analysis to examine relationships between cytokines among a sample of pediatric participants ME/CFS. Methods 10,119 youth aged 5–17 the Chicagoland area were screened for ME/CFS; 111 subjects and controls brought physician examination completed blood draw. Youth classified as (Cs, N = 43), ME/CFS...
Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS). occurs when an organism is exposed repeatedly to initially sub-threshold stimulus re-sulting in hypersensitivity and spontaneous seizure-like activity. Among patients with ME/CFS, chronically repeated low-intensity stimulation due infectious illness cause kindling limbic-hypothalamic-pituitary axis. also occur by high-intensity (e.g., brain trauma) Once...
It has become increasingly evident that gene expression processes in eukaryotes involve communication and coordination between many complex, independent macromolecular machines. To query these to explore the potential relationships them budding yeast Saccharomyces cerevisiae , we designed a versatile reporter using multicolor high-throughput flow cytometry. Due its design, this single exhibits distinctive signature for defects including transcription, histone modification, pre-mRNA splicing,...
Objective: This study examined the levels of a major regulator neuronal survival, brain derived neurotrophic factor (BDNF) in two populations: individuals with multiple sclerosis and chronic fatigue syndrome.BDNF is protein involved maintenance maturation both peripheral central neurons.In patients sclerosis, BDNF expression often decreased believed to reflect ineffective repair mechanisms.As preliminary exploration, we production on part blood mononuclear cells three groups: Chronic Fatigue...
Background and Objective: Previous research has speculated on the role of pro- inflammatory immune mediators in etiologic process fatigue, with contrasting findings. The preponderance evidence supports disease Chronic Fatigue Syndrome (CFS). purpose this study was to evaluate production interleukin (IL)-8 by peripheral blood mononuclear cells derived from individuals chronic fatigue. A secondary objective determine if there a significant relationship between IL-8 plasma cortisol level....
Abstract The ability to regulate stress is a critical developmental milestone of early childhood that involves set interconnected behavioral and physiological processes influenced by genetic environmental stimuli. Prenatal exposure traumatic trauma, including intimate partner violence (IPV), increases risk for offspring biobehavioral regulation problems during adolescence. Although individual differences in susceptibility prenatal have been largely unexplored, handful studies suggest...
Background We followed college students before, during, and after infectious mononucleosis (IM) for the development of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).Aim used network analysis to study relationships between pre-illness cytokine data amongst three groups participants: those 30 who went on develop ME/CFS following IM (and met one case definition), 18 severe (S-ME-CFS) greater than 58 recovered (controls).Methods recruited 4501 students; approximately 5% developed...
ABSTRACTObjective: Understanding how nonpharmacologic interventions differentially affect the subgroups of patients with chronic fatigue syndrome (CFS) might provide insights into pathophysiology this illness. In exploratory study, baseline measures normal versus abnormal cortisol were compared on a variety immune markers and other self-report measures. Normal ratings used as predictors in nurse-delivered intervention. Methods: Participants diagnosed CFS assigned to 6-month interventions....
A wide array of physiologic mechanisms has been proposed to explain the symptomatology and pathogenesis chronic fatigue syndrome. One consistent finding points potential disruptions hypothalamic-pituitary-adrenal (HPA) axis functioning concomitant with hypocortisolism. While there are divergent theories, evidence found for a possible lack responsiveness on part HPA challenge, pattern glucocorticoid resistance, disruption or dysregulation expected diurnal cortisol among patients CFS. Some...
Hypocortisolism is a frequent finding in individuals with chronic fatigue syndrome (CFS) and could play an explanatory role the development of illness symptomatology. The etiologic mechanism behind this be genetic variance glucocorticoid receptor expression (GR) or increased resistance to effects glucocorticoids. Several investigators believe that allelic GR (NR3C1) mediates possibly through influence on hypothalamic-pituitary-adrenal (HPA) axis function [1]. In addition, several immunologic...
Background: Cytokine studies in chronic fatigue syndrome (CFS) have yielded mixed findings.Purpose: This investigation evaluated whether network analysis of cytokine production differs between patients with CFS and multiple sclerosis (MS) as compared to a reference group healthy controls.Methods: Three subgroups (N = 109) were included: 15 participants who met diagnostic criteria for CFS, 57 meeting MS, 37 controls. Peripheral blood was obtained select profile determined from stimulated...