A5022931513- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Polyomavirus and related diseases
- Hepatitis Viruses Studies and Epidemiology
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Traditional Chinese Medicine Studies
- Machine Learning in Healthcare
- HIV, Drug Use, Sexual Risk
- Immunotherapy and Immune Responses
- Viral-associated cancers and disorders
- Hematopoietic Stem Cell Transplantation
- SARS-CoV-2 and COVID-19 Research
- COVID-19 diagnosis using AI
- Respiratory viral infections research
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Infection Control and Ventilation
WinnMed
2011-2023
Mayo Clinic
2014-2023
Mayo Clinic in Florida
2010-2023
Mayo Clinic in Arizona
2009-2022
Moffitt Cancer Center
2019
Creative Research Enterprises (United States)
2016
Office of Infectious Diseases
1990-2015
Understanding temporal dynamics of COVID-19 symptoms could provide fine-grained resolution to guide clinical decision-making. Here, we use deep neural networks over an institution-wide platform for the augmented curation notes from 77,167 patients subjected PCR testing. By contrasting Electronic Health Record (EHR)-derived COVID-19-positive (COVID pos ; n = 2,317) versus COVID-19-negative neg 74,850) week preceding testing date, identify anosmia/dysgeusia (27.1-fold), fever/chills...
Abstract Background Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection has disproportionately affected older individuals and those with underlying medical conditions. Research focused on short-term outcomes in hospital, single organ involvement. Consequently, impact of long COVID (persistent symptoms three months post-infection) across multiple organs low-risk is yet to be assessed. Methods An ongoing prospective, longitudinal, two-centre, observational study was...
BackgroundSince the 1918 influenza pandemic, non-randomised studies and small clinical trials have suggested that convalescent plasma or anti-influenza hyperimmune intravenous immunoglobulin (hIVIG) might benefit for patients with infection, but definitive data do not exist. We aimed to evaluate safety efficacy of hIVIG in a randomised controlled trial.MethodsThis randomised, double-blind, placebo-controlled trial was planned 45 hospitals Argentina, Australia, Denmark, Greece, Mexico, Spain,...
ABSTRACT Understanding how some HIV-infected cells resist the cytotoxicity of HIV replication is crucial to enabling cure efforts. killing CD4 T that replicate can involve protease-mediated cleavage procaspase 8 generate a fragment (Casp8p41) directly binds and activates mitochondrial proapoptotic protein BAK. Here, we demonstrate Casp8p41 also with nanomolar affinity antiapoptotic Bcl-2, which sequesters prevents apoptosis. Further, show central memory (T CM ) from individuals have...
People living with HIV (PLWH) are diagnosed cancer at an increased rate over the general population and generally have a higher mortality due to delayed diagnoses, advanced stage, comorbidities, immunosuppression, treatment disparities. Lack of guidelines provider education has led substandard care being offered PLWH. To fill that gap, NCCN Guidelines for Cancer in PLWH were developed; they provide recommendations who develop non–small cell lung cancer, anal Hodgkin lymphoma, cervical...
To compare coronavirus disease 2019 (COVID-19) acute kidney injury (AKI) to sepsis-AKI (S-AKI). The morphology and transcriptomic proteomic characteristics of autopsy kidneys were analyzed.Individuals 18 years age older who died from COVID-19 had an performed at Mayo Clinic between April 2020 October included. Morphological evaluation the 17 individuals with was performed. In a subset seven cases postmortem interval less than or equal 20 hours, ultrastructural molecular (targeted...
The burden of senescent cells (SnCs), which do not divide but are metabolically active and resistant to death by apoptosis, is increased in older adults those with chronic diseases. These individuals also at the greatest risk for morbidity mortality from SARS-CoV-2 infection. complications include cytokine storm multiorgan failure mediated same factors as often produced SnCs through their senescence-associated secretory phenotype (SASP). SASP can be amplified infection-related...
Background Notwithstanding 1 documented case of HIV-1 cure following allogeneic stem cell transplantation (allo-SCT), several subsequent cases allo-SCT in positive individuals have failed to infection. The aim our study was describe changes the HIV reservoir a single chronically HIV-infected patient on suppressive antiretroviral therapy who underwent for treatment acute lymphoblastic leukemia. Methods and findings We prospectively collected peripheral blood mononuclear cells (PBMCs) by...
As treatment of HIV has improved, people living with (PLWH) have experienced a decreased risk AIDS and AIDS-defining cancers (non-Hodgkin’s lymphoma, Kaposi sarcoma, cervical cancer), but the sarcoma in PLWH is still elevated about 500-fold compared general population United States. The NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for AIDS-Related Sarcoma provide diagnosis, treatment, surveillance recommendations who develop limited cutaneous those advanced cutaneous, oral,...
HIV infected patients have an increased susceptibility to liver disease due Hepatitis B Virus (HBV), C (HCV), alcoholic, and non-alcoholic steatohepatitis. Clinically, this results in limited options for antiretroviral therapy accelerated rates of disease, causing be the second leading cause death patients. The mechanisms propensity dysfunction during remains unknown.We demonstrate that and/or glycoprotein gp120 ligation CXCR4 on hepatocytes selectively up-regulates TRAIL R2 expression...
Understanding temporal dynamics of COVID-19 patient symptoms could provide fine-grained resolution to guide clinical decision-making. Here, we use deep neural networks over an institution-wide platform for the augmented curation notes from 77,167 patients subjected PCR testing. By contrasting Electronic Health Record (EHR)-derived COVID-19-positive (COVID pos ; n=2,317) versus COVID-19-negative neg n=74,850) week preceding testing date, identify anosmia/dysgeusia (27.1-fold), fever/chills...
ObjectiveTo report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19) related to patient outcomes.MethodsWe conducted a retrospective chart review of patients COVID-19 diagnosed between March 1, 2020, and July 31, at any sites. We abstracted pertinent comorbid conditions such as age, sex, body mass index, Charlson Comorbidity Index variables, treatments received. Factors associated hospitalization mortality were assessed in univariate multivariate models.ResultsA total 7891...
Universal human immunodeficiency virus (HIV) screening remains low in many clinical practices despite published guidelines recommending for all patients between ages 13–65. Electronic decision support tools have improved rates chronic diseases. We designed a quality improvement project to improve the rate of universal HIV adult Midwest primary care practice using tool. conducted this Rochester, Minnesota from January 1, 2014 December 31, 2014. Baseline data were acquired April 30, surveyed...
The glycoprotein hormones (LH, hCG, FSH, and TSH) have a common 92-amino acid α-subunit whiph is noncovalently linked to hormone-specific β-subunit. Synthetic peptides of the been shown inhibit binding [125I]iodo-hCG rat ovarian membrane [125I]iodo-TSH human thyroid preparations. overlapping hCG were prepared by solid phase techniques tested in standard vitro Leydig cell bioassay. Three regions (αl–15, α30–45, α71–85) found stimulate testosterone production. All three correlate with...
ABSTRACT Background In COVID-19, high levels of granulocyte macrophage-colony stimulating factor (GM-CSF) and inflammatory myeloid cells correlate with disease severity, cytokine storm, respiratory failure. With this rationale, we used lenzilumab, an anti-human GM-CSF monoclonal antibody, to treat patients severe critical COVID-19 pneumonia. Methods Hospitalized pneumonia risk factors for poor outcomes were treated lenzilumab 600 mg intravenously three doses through emergency single-use IND...
Numerous host and viral factors are capable of causing death HIV infected cells, uninfected bystander or both. We assessed the relevance protease in cell killing by mutating its obligate substrate for death, procaspase 8. VSV pseudotyped infection cells expressing WT caspase 8 resulted apoptotic generation specific cleavage product 8, casp8p41. Conversely, both casp8p41 production were inhibited engineered to be resistant cleavage. Lymph nodes from HIV-infected patients with ongoing...
Abstract Background Post-operative management of patients undergoing cardiac transplantation with an infected left ventricular assist device (LVAD) is unclear. Methods We retrospectively screened all adults LVAD who underwent at our institution from 2010 through 2018. selected cases LVAD-specific and LVAD-related infections were receiving antimicrobial therapy as initial treatment course or chronic suppression the time transplantation. Non-LVAD infections, superficial driveline-infection,...
Persistent inflammation and incomplete immune recovery among persons with HIV (PHIV) are associated increased disease risk. We hypothesized that the angiotensin receptor blocker (ARB) losartan would reduce by mitigating nuclear factor (NF)κB responses promote T-cell via inhibition of transforming growth factor-beta (TGFβ)-mediated fibrosis.Losartan (100 mg) versus placebo over 12 months was investigated in a randomized (1 : 1) placebo-controlled trial, PHIV age at least 50 years, receiving...