A5007610928- Celiac Disease Research and Management
- Mycobacterium research and diagnosis
- Microscopic Colitis
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Cytomegalovirus and herpesvirus research
- Clostridium difficile and Clostridium perfringens research
- Long-Term Effects of COVID-19
- Bacterial Infections and Vaccines
- Streptococcal Infections and Treatments
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Infectious Diseases and Tuberculosis
- Urinary Tract Infections Management
- Cardiac Structural Anomalies and Repair
- Infectious Diseases and Mycology
- Helminth infection and control
- Parasite Biology and Host Interactions
- Actinomycetales infections and treatment
- Parasites and Host Interactions
- Mechanical Circulatory Support Devices
- Infective Endocarditis Diagnosis and Management
- Neutropenia and Cancer Infections
- Tuberculosis Research and Epidemiology
- Orthopedic Infections and Treatments
University of Nebraska Medical Center
2021-2025
Universidad del Desarrollo
2023
Clínica Alemana
2023
Mayo Clinic
2019-2021
Mayo Clinic in Florida
2020-2021
Mayo Clinic in Arizona
2019-2021
WinnMed
2020-2021
Office of Infectious Diseases
2021
University of Central Florida
2017
Florida College
2017
Probiotics are believed to be beneficial in maintaining a healthy gut microbiota whereas antibiotics known induce dysbiosis. This study aimed examine the effects of probiotic Saccharomyces boulardii CNCM I-745 (SB), antibiotic Amoxicillin-Clavulanate (AC) and combination on symptoms humans.Healthy subjects were randomized one 4 groups: SB for 14 days, AC 7 plus AC, Control (no treatment). Participants gave stool samples completed gastro-intestinal symptom questionnaires. Microbiota changes...
Guidelines recommend routine screening of liver function tests (LFTs) in patients diagnosed with celiac disease (CD). However, little is known about the prevalence disorders CD outside Europe. Our aims were to estimate LFT abnormalities and evaluate effect a gluten-free diet (GFD) on LFTs.Adult biopsy-proven identified from prospectively maintained database matched healthy controls. levels for women men defined as abnormal based Third National Health Nutrition Examination Survey (NHANES III)...
Nocardial brain abscesses are rare, and published literature describing due to Nocardia species is limited individual case reports or small series. We report one of the largest contemporary retrospective studies risk factors, diagnostic evaluation, management, outcomes nocardial abscess.Retrospective review all adults with abscess culture-confirmed at our institution between January 1, 2009, June 30, 2020.Overall, 24 patients had during study period. The median age presentation was 64 years,...
Background/Objectives: Individuals with immunocompromising conditions are at high risk of developing severe respiratory syncytial virus (RSV) illness. This phase 3, single-arm study assessed the safety and immunogenicity bivalent RSV prefusion F protein−based (RSVpreF) 120-µg vaccine in immunocompromised renally impaired adults. Methods: Participants were stratified by age group (18−<60-year-olds; ≥60-year-olds) received two RSVpreF doses 1 month apart (i.e., Dose 2, respectively)....
ObjectiveTo report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19) related to patient outcomes.MethodsWe conducted a retrospective chart review of patients COVID-19 diagnosed between March 1, 2020, and July 31, at any sites. We abstracted pertinent comorbid conditions such as age, sex, body mass index, Charlson Comorbidity Index variables, treatments received. Factors associated hospitalization mortality were assessed in univariate multivariate models.ResultsA total 7891...
The objective of this study was to determine our institution's compliance with 2010 Society for Healthcare Epidemiology America and IDSA Clostridium difficile infection (CDI) treatment guidelines their respective outcomes.We collected clinical parameters, laboratory values, antibiotic therapy outcomes from the electronic medical records all patients hospitalized at institution a diagnosis CDI December 2012 November 2013. We specifically evaluated whether SHEA-IDSA were followed associations...
Abstract Background Post-operative management of patients undergoing cardiac transplantation with an infected left ventricular assist device (LVAD) is unclear. Methods We retrospectively screened all adults LVAD who underwent at our institution from 2010 through 2018. selected cases LVAD-specific and LVAD-related infections were receiving antimicrobial therapy as initial treatment course or chronic suppression the time transplantation. Non-LVAD infections, superficial driveline-infection,...
Mycobacterium marinum is a common but underreported mycobacterial infection. We conducted large retrospective study to determine risk factors and describe the therapeutic interventions outcomes in patients with uncomplicated complicated M. infection.Culture-confirmed infection cases were identified from Mayo Clinic Clinical Mycology Laboratory January 1998 December 2018. Complicated was defined as presence of tenosynovitis, septic arthritis, or osteomyelitis. Differences vs infections...
We report the case of a 71-year-old man who presented 2 years following renal transplantation with diffuse, unilateral cytomegalovirus retinitis five weeks after receiving an intravitreal dexamethasone implant device for management central retinal vein occlusion. Examination left eye showed diffuse hemorrhages, attenuated and tortuous vessels, superior whitening. The patient was successfully treated serial foscarnet injections oral valganciclovir disease regression observed by 12...
Bloodstream infections (BSI) with rapidly growing mycobacteria (RGM) resulted in recent nosocomial outbreaks predominantly immunocompromised patients. A little is known about the clinical implications of RGM BSI different species.We conducted a multicenter retrospective cohort study patients from November 2011 to December 2020. Demographic data, presentation, laboratory and radiographic findings microbiological characteristics were used tabulate descriptive statistics. We performed...
Ascertaining involvement of left ventricular assist device (LVAD) in a patient presenting with bloodstream infection (BSI) can be challenging, frequently leading to use chronic antimicrobial suppressive (CAS) therapy. We aimed assess the efficacy CAS therapy prevent relapse BSI from LVAD and non-LVAD sources. retrospectively screened adults receiving support 2010 through 2018, identify cases BSI. Bloodstream events were classified into LVAD-related, LVAD-associated, BSIs. A total 121...
Abstract Purpose To identify risk factors that may predispose patients to rifampin- and cefazolin-induced coagulopathy. Summary An 86-year-old man with a history of rheumatoid arthritis on chronic prednisone stage 3 kidney disease, notably not warfarin, presented the hospital 10-day right hip pain, swelling, drainage after recent total-hip arthroplasty. The patient underwent combination surgical intervention medication therapy rifampin ceftriaxone. After discharge at postoperative day 9,...
Background. Kidney transplantation (KT) has dramatically improved the quality of life patients with end-stage kidney disease. However, incidence opportunistic infections also increased because immunosuppression. A common infection after KT is cytomegalovirus (CMV). In recipients, we assessed efficacy and safety fiztasovimab (NPC-21), an anti-CMV monoclonal antibody. Methods. This was a multicenter, randomized, double-blind, placebo-controlled, phase 2 study NPC-21 for recipients CMV...