A5077659236- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dysphagia Assessment and Management
- Gastroesophageal reflux and treatments
- Transplantation: Methods and Outcomes
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Neonatal Respiratory Health Research
- Cardiac Arrest and Resuscitation
- Respiratory and Cough-Related Research
- Vasculitis and related conditions
- Infection Control and Ventilation
- Organ Transplantation Techniques and Outcomes
- Inhalation and Respiratory Drug Delivery
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- Thermal Regulation in Medicine
- COVID-19 and healthcare impacts
- Cardiovascular Function and Risk Factors
- Asthma and respiratory diseases
- Tuberous Sclerosis Complex Research
- Long-Term Effects of COVID-19
Mayo Clinic in Florida
2015-2024
Mayo Clinic
2004-2024
WinnMed
2012-2024
Jacksonville College
2012-2024
Mayo Clinic in Arizona
2011-2024
Pulmonary Associates
2018
Pulmonary and Allergy Associates
2002-2013
Max Planck Society
2004
Abstract Objective Human neutrophil elastase (HNE) and proteinase 3 (PR3) are structurally functionally related. PR3 is the prominent target antigen for antineutrophil cytoplasmic antibodies (ANCAs) in Wegener's granulomatosis (WG). Reported frequencies of HNE ANCAs WG other autoimmune diseases range from 0% to 20%. We previously detected patients with cocaine‐induced midline destructive lesions (CIMDL). tested hypothesis that discrepancies reported vasculitis may be related differences...
Pulmonary disease is a potentially serious yet underdiagnosed complication of Sjögren's syndrome, the second most common autoimmune rheumatic disease. Approximately 16% patients with demonstrate pulmonary involvement higher mortality and lower quality life.
Rationale: Global Lung Function Initiative (GLI) spirometry reference equations were recently derived to offer a “race-neutral” interpretation option. The impact of transitioning from the race-specific GLI-2012 GLI is unknown. Objectives: Describe direction and magnitude changes in predicted lung function measurements population diverse race / ethnicity using place equations. Methods: In this multicenter cross-sectional study large pulmonary laboratory database, 109,447 tests reanalyzed...
Objective Avacopan, an activated complement factor 5 receptor antagonist, has been approved as adjunct therapy for severe active antineutrophil cytoplasmic antibody–associated vasculitis (AAV). Current evidence supports the management of AAV presenting with diffuse alveolar hemorrhage (DAH) by administering glucocorticoids combined either rituximab or cyclophosphamide in addition to supportive care. The role avacopan patients DAH a primary disease manifestation not well established....
OBJECTIVES: Gastroesophageal reflux is common in patients post-lung transplantation (LTx) and thus considered a risk factor for aspiration consequently allograft rejection the development of chronic failure. However, evidence supporting this remains unclear often contradictory. Our aim was to examine role played by esophageal motility on gastroesophageal exposure, along with its clearance that boluses swallowed, relationship obstructive lung dysfunction (o-CLAD). METHODS: Patients post-LTx...
Abstract Background Spirometry can be performed in an office setting or remotely using portable spirometers. Although basic spirometry is used for diagnosis of obstructive lung disease, clinically relevant information such as restriction, hyperinflation, and air trapping require additional testing, body plethysmography, which not readily available. We hypothesize that data contains allow estimation static volumes certain circumstances by leveraging machine learning techniques. Objective The...
Objective Baclofen is a centrally acting γ-aminobutyric acid type B (GABA ) receptor agonist which reduces gastro-oesophageal reflux and suppresses the cough reflex; however, central nervous system side-effects limit its use. Lesogaberan novel peripherally GABA agonist, but effects on refractory chronic are unknown. Design We performed single-centre, placebo-controlled, double-blind randomised crossover study in patients with cough, to treatment of underlying conditions. Patients were...
ObjectiveTo report the Mayo Clinic experience with coronavirus disease 2019 (COVID-19) related to patient outcomes.MethodsWe conducted a retrospective chart review of patients COVID-19 diagnosed between March 1, 2020, and July 31, at any sites. We abstracted pertinent comorbid conditions such as age, sex, body mass index, Charlson Comorbidity Index variables, treatments received. Factors associated hospitalization mortality were assessed in univariate multivariate models.ResultsA total 7891...
To determine risk factors for development of recurrent acute lung injury.A population-based case-control study.The study was conducted in Olmsted County, MN, from 1999 to 2008.Using a validated electronic screening protocol, investigators identified intensive care patients with hypoxemia and bilateral pulmonary infiltrates.None.The presence injury independently confirmed according American-European Consensus Conference criteria. Recurrent cases were subsequently matched (1:1:1) two controls...
Pulmonary hypertension (PH) has been found to have significant morbidity and mortality. The treatment of PH advanced considerably with increasingly more effective safer options. With an increasing effort diagnose patients early, non-invasive techniques are often used screen those likely PH. Computerized tomography (CT) chest scans utilized in the evaluation exertional dyspnea, including suspected main role CT scan is evaluate for any associated underlying diseases. There attempts address...
Obstructive sleep apnea (OSA) may increase the risk of respiratory complications and acute distress syndrome (ARDS) among surgical patients. OSA is more prevalent obese individuals; obesity can predispose to ARDS.It unclear whether independently contributes towards ARDS hospitalized patients.This a pre-planned retrospective subgroup analysis prospectively identified cohort 5,584 patients across 22 hospitals with at least one factor for time hospitalization from trial by US Critical Illness...