A5013586561- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- LGBTQ Health, Identity, and Policy
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Adolescent Sexual and Reproductive Health
- Syphilis Diagnosis and Treatment
- Sex work and related issues
- HIV-related health complications and treatments
- Infectious Diseases and Tuberculosis
- Herpesvirus Infections and Treatments
- African Sexualities and LGBTQ+ Issues
- Sarcoidosis and Beryllium Toxicity Research
- Orthopedic Infections and Treatments
- Reproductive Health and Technologies
- Reproductive tract infections research
- Mosquito-borne diseases and control
- Vaccine Coverage and Hesitancy
- Viral-associated cancers and disorders
- COVID-19 Impact on Reproduction
- Pneumocystis jirovecii pneumonia detection and treatment
- Long-Term Effects of COVID-19
- Hepatitis C virus research
Massachusetts General Hospital
2017-2024
Harvard University
2011-2024
Fenway Health
2017-2023
Massachusetts Department of Public Health
2023
New York City Department of Health and Mental Hygiene
2023
Pontificia Universidad Católica de Chile
2023
Association for Rural Development
2022
Office of Infectious Diseases
2021
Brigham and Women's Hospital
2011-2017
Lemuel Shattuck Hospital
2017
People living with HIV (PLWH) are diagnosed cancer at an increased rate over the general population and generally have a higher mortality due to delayed diagnoses, advanced stage, comorbidities, immunosuppression, treatment disparities. Lack of guidelines provider education has led substandard care being offered PLWH. To fill that gap, NCCN Guidelines for Cancer in PLWH were developed; they provide recommendations who develop non–small cell lung cancer, anal Hodgkin lymphoma, cervical...
Many people living with HIV (PLWH) have comorbidities which are risk factors for severe coronavirus disease 2019 (COVID-19) or exposures that may lead to acquisition of acute respiratory distress syndrome 2. There few studies, however, on the demographics, comorbidities, clinical presentation, outcomes COVID-19 in HIV.To evaluate factors, manifestations, and a large cohort PLWH COVID-19.We systematically identified all who were diagnosed at hospital from 3 March 26 April 2020 during an...
As treatment of HIV has improved, people living with (PLWH) have experienced a decreased risk AIDS and AIDS-defining cancers (non-Hodgkin’s lymphoma, Kaposi sarcoma, cervical cancer), but the sarcoma in PLWH is still elevated about 500-fold compared general population United States. The NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for AIDS-Related Sarcoma provide diagnosis, treatment, surveillance recommendations who develop limited cutaneous those advanced cutaneous, oral,...
We determined the impact of obtaining housing on geriatric conditions and acute care utilization among older homeless adults.We conducted a 12-month prospective cohort study 250 adults recruited from shelters in Boston, Massachusetts, between January June 2010. status at follow-up, number emergency department visits hospitalizations over 12 months, examined 4 measures baseline months. Using multivariable regression models, we evaluated association our outcomes interest.At 41% participants...
Opioid use disorder poses a significant public health risk. Persons who inject drugs (PWID) suffer from high mortality and morbidity secondary to serious infectious diseases, often requiring prolonged courses of outpatient parenteral antibiotics. The goal this study was determine the outcomes PWID discharged home or skilled nursing rehabilitation facility (SNF/rehab) with antibiotic treatment under an antimicrobial therapy (OPAT) program.This is retrospective observational study. population...
The focus of sexual and gender minority health education has shifted to cover training for all clinicians, been increasingly mandated by centers, departments, hospital leaders. This change created new challenges opportunities.
Abstract Coronavirus disease (COVID-19) is responsible for a global pandemic. It important to balance the need access healthcare services, including testing and treatment sexually transmitted infections. Sexually infection programs must consider how use limited resources implement novel approaches provide continued care.
Men who have sex with men (MSM) are disproportionately affected by HIV. Given that over 70% of MSM meet sexual partners via dating apps, such apps may be an effective platform for promoting HIV pre-exposure prophylaxis (PrEP) use. We aimed to describe preferences among PrEP advertisements displayed on apps. conducted individual in-depth interviews 16 recruited from a mobile health unit in Boston, Massachusetts. Two focus groups were also held: one staff (
The clinical spectrum of septic arthritis in the era opioid crisis is ill-defined.This a retrospective chart review 1465 cases culture-positive native joint at Boston teaching hospitals between 1990 and 2018.Between 1990-2008 2009-2018, proportion involving people who inject drugs (PWID) rose from 10.3% to 20% (P < .0000005). Overall, methicillin-sensitive Staphylococcus aureus (MSSA) caused 41.5% cases, methicillin-resistant (MRSA) 17.9%. Gram-negative rods only 6.2% cases. Predictors MRSA...
A Man with Headache and Covid-19 24-year-old man was admitted to the hospital a 3-week history of headache positive test for SARS-CoV-2 RNA. MRI showed multiple small hyperintense foci...
Abstract Background Septic arthritis of the spinal facet joints is increasingly recognized in era magnetic resonance imaging, but its epidemiology, clinical features, management, and prognosis are ill-defined. Methods We review 101 previously published cases report 16 occurring at our institutions between 2006 2018. Results Most patients presented with fever (60%) back or neck pain (86%). Radiation into hip, buttock, limb was present 34%. The lumbosacral vertebral segments were involved 78%...
Abstract A clinical decision support system, EvalMpox, was developed to apply person under investigation (PUI) criteria for patients presenting with rash and recommend testing PUIs. Of 668 evaluated, an EvalMpox recommendation had a positive predictive value of 35% negative 99% mpox test.
Despite the promise of human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP), PrEP remains underutilized, often due to clinician factors. Academic or public health detailing is a process by which university and/or government groups employ marketing practices pharmaceutical companies improve clinical practice. We describe novel application increase prescribing and related care in New York City England. Detailing can play crucial role implementation.
Virologic failure in HIV predicts the development of drug resistance and mortality. Genotypic testing (GRT), which is standard care after virologic high-income settings, rarely implemented sub-Saharan Africa.
Abstract Background Diagnosis of Neisseria (N.) gonorrhoeae is dependent on nucleic acid amplification testing (NAAT), which not available in resource-limited settings where the prevalence infection highest. Recent advances molecular diagnostics leveraging high specificity CRISPR enzymes can permit field-deployable, point-of-care lateral flow assays. We previously reported development and vitro performance a assay for detecting N. . Here we aimed to pair that with DNA extraction techniques...
A 63-year-old man with a history of primary membranous nephropathy presented fever, confusion, headache, garbled speech, vision changes, lymphocytic pleocytosis, and an elevated CSF protein level. MRI the head revealed sulcal hyperintensity on FLAIR images, associated subtle enhancement T1-weighted images. diagnosis was made.
Abstract Background HIV preexposure prophylaxis (PrEP) uptake among men who have sex with (MSM), a group disproportionately impacted by HIV, is not commensurate need. Settings which reduce or remove barriers to accessing care are promising venues support PrEP uptake. provision at mobile clinics represents novel strategy increase access; however, the acceptability and feasibility of this approach been well studied. Methods Our objective was understand patient staff experiences clinic van...
Abstract Zika virus (ZIKV) is a mosquito-borne pathogen with increasing public health significance. To characterize immune responses to ZIKV, here we examine transcriptional signatures of CD4 T, CD8 B, and NK cells, monocytes, myeloid dendritic cells (mDCs), plasmacytoid (pDCs) from three individuals ZIKV infection. While gene expression patterns most cell subsets display signs impaired antiviral activity, pDCs infected host have distinct response associated activation innate recognition...