A5034382018- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Long-Term Effects of COVID-19
- Cardiac Valve Diseases and Treatments
- COVID-19 Clinical Research Studies
- Diabetes Treatment and Management
- Heart Rate Variability and Autonomic Control
- Steroid Chemistry and Biochemistry
- Cardiovascular Disease and Adiposity
- Infectious Encephalopathies and Encephalitis
- Cardiovascular Health and Disease Prevention
- Cholesterol and Lipid Metabolism
- Thermal Regulation in Medicine
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Adrenal Hormones and Disorders
- Immune Response and Inflammation
- Receptor Mechanisms and Signaling
- Clusterin in disease pathology
- Synthesis and biological activity
- Apelin-related biomedical research
- Bioactive natural compounds
University of Oxford
2012-2024
Great Western Hospital
2021-2024
London Clinic
2024
Great Western Hospitals NHS Foundation Trust
2020-2023
Oxford University Hospitals NHS Trust
2017-2023
University College London
2022
Martin University
2021
Oxford Centre for Diabetes, Endocrinology and Metabolism
2019-2021
GW4
2020
John Radcliffe Hospital
2019
Objective To assess medium-term organ impairment in symptomatic individuals following recovery from acute SARS-CoV-2 infection. Design Baseline findings a prospective, observational cohort study. Setting Community-based two UK centres between 1 April and 14 September 2020. Participants Individuals ≥18 years with persistent symptoms infection age-matched healthy controls. Intervention Assessment of by standardised questionnaires (EQ-5D-5L, Dyspnoea-12) organ-specific metrics biochemical...
BackgroundThe effects of pharmacological blood-pressure-lowering on cardiovascular outcomes in individuals aged 70 years and older, particularly when blood pressure is not substantially increased, uncertain. We compared the treatment risk major events groups patients stratified by age at baseline.MethodsWe did a meta-analysis using individual participant-level data from randomised controlled trials versus placebo or other classes medications, between more less intensive strategies, which had...
Nicotinic acid (NA) treatment has been associated with benefits in atherosclerosis that are usually attributed to effects on plasma lipoproteins. The NA receptor GPR109A is expressed monocytes and macrophages, suggesting a possible additional role for modulating function of these immune cells. We hypothesize the potential act directly alter mediators inflammation may contribute its antiatherogenic vivo.In human activated by Toll-like (TLR)-4 agonist lipopolysaccharide, reduced secretion...
Abstract Background Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection has disproportionately affected older individuals and those with underlying medical conditions. Research focused on short-term outcomes in hospital, single organ involvement. Consequently, impact of long COVID (persistent symptoms three months post-infection) across multiple organs low-risk is yet to be assessed. Methods An ongoing prospective, longitudinal, two-centre, observational study was...
Background Long COVID is associated with multiple symptoms and impairment in organs. Cross-sectional studies have reported cardiac to varying degrees by methodologies. Using MR (CMR), we investigated a 12-month trajectory of abnormalities COVID. Objectives To investigate 1-year post-SARS-CoV-2 infection. Methods 534 individuals underwent CMR (T1/T2 mapping, mass, volumes, function strain) multiorgan MRI at 6 months (IQR 4.3–7.3) since first post-COVID-19 symptoms. 330 were rescanned 12.6...
Insulin resistance (IR) may mediate heart failure (HF) development. We examined whether IR in people with newly diagnosed type 2 diabetes (T2D) increased their risk of a composite outcome HF or death alone.Insulin (HOMA2-IR) values for UKPDS participants were derived from paired fasting plasma glucose (FPG) and insulin measures. Kaplan-Meier survival curves multivariable models used to evaluate associations between HOMA2-IR HF/death alone. adjusted potential confounders by including...
The study objective was to determine the key early mechanisms underlying beneficial redistribution, function, and inflammatory profile of adipose tissue in 11β-hydroxysteroid dehydrogenase type 1 knockout (11β-HSD1(-/-)) mice fed a high-fat (HF) diet.
Despite major advances in understanding monogenic causes of morbid obesity, the complex genetic and environmental etiology idiopathic metabolic syndrome remains poorly understood. One hypothesis suggests that similarities between disease plasma glucocorticoid excess (Cushing’s syndrome) results from increased reamplification within adipose tissue by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1). Indeed, 11β-HSD-1 is now a therapeutic target. Because much supporting evidence for role...
Obesity is associated with an increased risk of diabetes type 2, dyslipidemia, and atherosclerosis. These cardiovascular metabolic abnormalities are exacerbated by excessive dietary fat, particularly cholesterol its metabolites. High adipose tissue glucocorticoid levels, generated the intracellular enzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), also implicated in pathogenesis obesity, syndrome, 11β-HSD1 interconverts atherogenic oxysterols 7-ketocholesterol (7KC) 7β-hydroxycholesterol...
Early risk stratification after ST-segment-elevation myocardial infarction (STEMI) is of major clinical importance. Strain quantifies deformation and can demonstrate abnormal global segmental function in acute ischaemia. Native T1-mapping allows assessment the severity ischemic injury, however its applicability early post MI limited by complex dynamic changes happening myocardium MI. We aimed to explore relationship between feature tracking imaging, establish whether combined analysis these...
Abstract Background Long Covid is associated with multiple symptoms and impairment in organs [1]. Cardiac has been reported to varying degrees by methodologies cross-sectional studies. Using cardiovascular magnetic resonance (CMR), we investigated the 12-month trajectory of cardiac individuals Covid. Purpose We conducted a prospective, longitudinal, 1-year study investigate 1) characteristics impairment; 2) impact acute hospitalisation for COVID-19 on 3) pathways designing improving clinical...
Severe aortic stenosis is a major cause of morbidity and mortality. The existing treatment pathway for transcatheter valve implantation (TAVI) traditionally relies on tertiary Heart Valve Centre workup. However, this has been associated with delays to treatment, in breach British Cardiovascular Intervention Society targets. A novel emphasis comprehensive patient workup at local centre, alongside close collaboration Centre, may help reduce the time TAVI.The centre performing implemented TAVI...
Abstract Diabetes is a heterogenous, multimorbid disorder with large variation in manifestations, trajectories, and outcomes. The aim of this study to validate novel machine learning method for the phenotyping diabetes context comorbidities. Data from 9967 patients new diagnosis were extracted Clinical Practice Research Datalink. First, using BEHRT (a transformer-based deep architecture), embeddings corresponding learned. Next, topological data analysis (TDA) was carried out test how...
Abstract Background Long Covid is associated with multiple symptoms and impairment in organs. Cardiac has been reported to varying degrees by methodologies cross-sectional studies. Using cardiac magnetic resonance (CMR), we investigated the 12-month trajectory of individuals Covid. Methods 534 underwent baseline CMR (T1 T2 mapping, mass, volumes, function, strain) multi-organ MRI at 6 months (IQR 4.3,7.3) since first post-COVID-19 330 were rescanned 12.6 11.4, 14.2) if abnormal findings...