A5035982639- Medieval History and Crusades
- Byzantine Studies and History
- Archaeology and Historical Studies
- Historical and Linguistic Studies
- Eurasian Exchange Networks
- Islamic Studies and History
- Medieval Literature and History
- Historical and Archaeological Studies
- Medieval European History and Architecture
- Hormonal Regulation and Hypertension
- Historical and Religious Studies of Rome
- Global Maritime and Colonial Histories
- Reformation and Early Modern Christianity
- African history and culture analysis
- Historical Geopolitical and Social Dynamics
- Diet and metabolism studies
- Historical Studies and Socio-cultural Analysis
- Ancient Near East History
- Military History and Strategy
- Historical and Architectural Studies
- Medieval Iberian Studies
- Archaeological Research and Protection
- Adrenal Hormones and Disorders
- European and Russian Geopolitical Military Strategies
- Cholesterol and Lipid Metabolism
Nottingham Trent University
2016-2025
University of Edinburgh
2004-2024
The Queen's Medical Research Institute
2007-2024
British Heart Foundation
2024
Université de Poitiers
2020
Swansea University
2009-2012
Western General Hospital
2004
West London Mental Health NHS Trust
1995
ABSTRACT Arterial calcification is an important hallmark of cardiovascular disease and shares many similarities with skeletal mineralization. The bone-specific protein osteocalcin (OCN) established marker vascular smooth muscle cell (VSMC) osteochondrogenic transdifferentiation a known regulator glucose metabolism. However, the role OCN in controlling arterial unclear. We hypothesized that regulates VSMCs sought to identify underpinning signaling pathways. Immunohistochemistry revealed...
Context: Dietary macronutrient composition influences cardiometabolic health independently of obesity. Both dietary fat and insulin alter glucocorticoid metabolism in rodents and, acutely, humans. However, whether longer-term differences macronutrients affect cortisol humans contribute to the tissue-specific dysregulation obesity is unknown.
Altered peripheral glucocorticoid metabolism may be important in the pathogenesis of obesity humans and animal models. Genetically obese Zucker rats, Lep/ob mice, exhibit increased regeneration active glucocorticoids selectively adipose tissue by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) clearance hepatic A-ring reductases. We have examined whether dietary rats induces same changes metabolism. Male Wistar were weaned onto high-fat (HF; 45% kcal from fat) or control (10% diets....
Summary Objective Glucocorticoid hyperactivity in adipose tissue, due to up‐regulation of local glucocorticoid reactivation by 11β‐hydroxysteroid dehydrogenase‐1 (11HSD1) or receptors (GR), may underpin susceptibility the metabolic syndrome. This hypothesis has been tested extensively subcutaneous tissue (SAT) but inadequately visceral (VAT). The aim study was therefore examine expression 11HSD1, GRα and hexose‐6‐phosphate dehydrogenase (H6PDH), which supplies cofactor for abdominal...
Court and Cosmos is essentially the catalogue for an exhibition of that name took place at Metropolitan Museum Art (New York) between April July 2016. The drew together a...
ABSTRACT Chronic kidney disease–mineral and bone disorder (CKD-MBD) presents with extra-skeletal calcification renal osteodystrophy (ROD). The origins of ROD likely lie elevated uremic toxins and/or an altered hormonal profile but the cellular events responsible remain unclear. Here, we report that stalled mitophagy contributes to mitochondrial dysfunction in bones a CKD-MBD mouse model, also human patients. RNA-seq analysis exposed expression genes associated function tibia mice....
Obesity is associated with an increased risk of diabetes type 2, dyslipidemia, and atherosclerosis. These cardiovascular metabolic abnormalities are exacerbated by excessive dietary fat, particularly cholesterol its metabolites. High adipose tissue glucocorticoid levels, generated the intracellular enzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), also implicated in pathogenesis obesity, syndrome, 11β-HSD1 interconverts atherogenic oxysterols 7-ketocholesterol (7KC) 7β-hydroxycholesterol...
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension. A role for local glucocorticoid reamplification in obesity syndrome has been suggested. The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates active cortisol from inactive 11-keto forms, aP2-HSD1 mice relative transgenic overexpression this fat cells develop visceral resistance dyslipidemia. Here we report that also...
The pathological mechanisms that distinguish simple steatosis from steatohepatitis (or NASH, with consequent risk of cirrhosis and hepatocellular cancer) remain incompletely defined. Whereas both a methionine- choline-deficient diet (MCDD) (CDD) lead to hepatic triglyceride accumulation, MCDD alone is associated insulin resistance inflammation (steatohepatitis). We used metabolic tracer techniques, including stable isotope ([ 13 C 4 ]palmitate) dilution mass isotopomer distribution analysis...
Abstract The emergence of bone as an endocrine regulator has prompted a re-evaluation the role mineralization factors in development metabolic disease. Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) controls through generation pyrophosphate and is elevated dermal fibroblast cultures muscle patients with insulin resistance. We investigated phenotype associated impaired metabolism mice lacking NPP1 gene (Enpp1-/- mice). Enpp1-/- exhibited mildly improved glucose homeostasis on...
Peter Jackson has long been recognised as a leading expert in the history of Mongols. His major studies, including The Mongols and West 1221–1410 1 Dehli Sultanate, 2 represent grou...
"Arabic-Islamic Views of the Latin West: Tracing Emergence Medieval Europe." Islam and Christian–Muslim Relations, 27(4), pp. 524–525
Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte deficiency of the oxygen-sensor HIF-prolyl hydroxylase (PHD2) gene overcomes BAT dormancy at thermoneutrality. Adipocyte-PHD2-deficient mice maintain higher energy expenditure having greater capacity. In and murine adipocytes, PHD inhibitor increases Ucp1...
This article explores the evolving use of Maccabaean ideas in sources concerning conduct Christian holy warfare between eleventh and thirteenth centuries. It demonstrates that memory Maccabees other Old Testament exemplars played an important role shaping idea crusading its subsequent evolution to encompass new frontiers Baltic Iberia, as well structural developments crusading, such establishment military orders.
Carole Hillenbrand is widely – and rightly recognised as a leading expert in the study of medieval Near East. She particularly well known for her broad survey history, The Crusades: Islami...
Abstract Supraphysiological levels of the osteoblast‐enriched mineralization regulator ectonucleotide pyrophosphatase or phosphodiesterase‐1 (NPP1) is associated with type 2 diabetes mellitus. We determined impact osteoblast‐specific Enpp1 ablation on skeletal structure and metabolic phenotype in mice. Female, but not male, 6‐week‐old mice lacking osteoblast NPP1 expression (osteoblast‐specific knockout [KO]) exhibited increased femoral bone volume total (17.50% vs. 11.67%; p < .01),...
Over the past decade Seljuks (especially Anatolian Seljuqs) have received an unprecedented amount of attention by scholars who had produced a huge range publications covering wide rang...