A5016309183- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Bone and Dental Protein Studies
- Bone health and treatments
- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Intraperitoneal and Appendiceal Malignancies
- Connective tissue disorders research
- Mitochondrial Function and Pathology
- Biomedical and Engineering Education
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Endoplasmic Reticulum Stress and Disease
- Inflammatory mediators and NSAID effects
- Diabetes Treatment and Management
- Alkaline Phosphatase Research Studies
- Inflammasome and immune disorders
- Pancreatic and Hepatic Oncology Research
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gallbladder and Bile Duct Disorders
- Fuel Cells and Related Materials
Charité - Universitätsmedizin Berlin
2022-2025
German Centre for Cardiovascular Research
2022-2025
Deutsches Herzzentrum der Charité
2024-2025
The Queen's Medical Research Institute
2020-2024
University of Edinburgh
2019-2024
Max Delbrück Center
2024
Qilu Hospital of Shandong University
2024
Qingdao University
2022-2023
Affiliated Hospital of Qingdao University
2022-2023
Centre for Inflammation Research
2019
Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of energy substrates. Among the different types HF, HF with preserved ejection fraction (HFpEF) a highly prevalent, complex, heterogeneous condition for which metabolic derangements seem to dictate disease progression. Changes intermediate metabolism cardiometabolic HFpEF-among most prevalent forms HFpEF-have large impact both on provision number signalling pathways heart. This dual, vs. signalling, role...
Pulmonary infections are a major global cause of morbidity, exacerbated by an increasing threat from antibiotic-resistant pathogens. In this context, therapeutic interventions aimed at protectively modulating host responses, to enhance defence against infection, take on ever greater significance. Pseudomonas aeruginosa is important multidrug-resistant, opportunistic respiratory pathogen, the clearance which can be enhanced in vivo innate immune modulatory properties antimicrobial peptides...
Evaluating the performance of Gallbladder Reporting and Data System (GB-RADS) combined with Color Doppler Flow Imaging (CDFI) for diagnosis gallbladder wall thickening disease in an Asian population.
Enhancing thermogenic brown adipose tissue (BAT) function is a promising therapeutic strategy for metabolic disease. However, predominantly thermoneutral modern human living conditions deactivate BAT. We demonstrate that selective adipocyte deficiency of the oxygen-sensor HIF-prolyl hydroxylase (PHD2) gene overcomes BAT dormancy at thermoneutrality. Adipocyte-PHD2-deficient mice maintain higher energy expenditure having greater capacity. In and murine adipocytes, PHD inhibitor increases Ucp1...
Ovarian tumors (OTs) are common gynecological in women. It is very important to correctly distinguish benign and malignant OTs.To assess the diagnostic performance of American College Radiology (ACR) Ovarian-Adnexal Reporting Data System (O-RADS) evaluate clinical value O-RADS combined with serum carbohydrate antigen 125 (CA125) human epididymis protein 4 (HE4) differentiating from OTs.A retrospective analysis was performed on 431 cases including pathology data. The receiver operating...
Objectives: To evaluate the diagnostic value of Ovarian-adnexal Reporting and Data System (O-RADS), to compare it with Assessment Different NEoplasias in adnexa (ADNEX) model, Subjective (SA), Risk Malignancy Index (RMI) differentiating benign malignant adnexal masses (AMs). Material methods: Ultrasound characteristics 445 patients included study were retrospectively analyzed evaluated using models. The performances ultrasound models measured by assessing, receiver-operating characteristic...
Biomineralization is a fundamental process key to the development of skeleton. The phosphatase orphan 1 (PHOSPHO1), which likely functions within extracellular matrix vesicles, has emerged as critical regulator biomineralization. However, biochemical pathways that generate intravesicular PHOSPHO1 substrates are currently unknown. We hypothesized enzyme ectonucleotide pyrophosphatase/phosphodiesterase 6 (ENPP6) an upstream source substrate. To test this, we characterized skeletal phenotypes...
To evaluate the safety and efficacy of microwave ablation (MWA) versus repeat surgery for treating metastatic lymph nodes (MLNs) in papillary thyroid carcinoma (PTC).Between July 2017 October 2020, 67 patients were enrolled this retrospective study. 19 48 underwent MWA surgery, respectively. The primary secondary endpoints recurrence-free survival complication rates, largest diameter, volume reduction ratio (VRR) analyzed before after MWA. effects different powers on VRR investigated. Pre...
Abstract Enhancing brown adipose tissue (BAT) function to combat metabolic disease is a promising therapeutic strategy. A major obstacle this strategy that thermoneutral environment, relevant most modern human living conditions, deactivates functional BAT. We showed we can overcome the dormancy of BAT at thermoneutrality by inhibiting main oxygen sensor HIF-prolyl hydroxylase, PHD2, specifically in adipocytes. Mice lacking adipocyte PHD2 ( P2 KO ad ) and housed maintained greater mass, had...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)