A5103124783- Thyroid Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Thyroid and Parathyroid Surgery
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Connexins and lens biology
- Head and Neck Cancer Studies
- Glutathione Transferases and Polymorphisms
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Extracellular vesicles in disease
- Head and Neck Anomalies
- Cell Adhesion Molecules Research
- Nerve injury and regeneration
- interferon and immune responses
- TGF-β signaling in diseases
- Gout, Hyperuricemia, Uric Acid
- Nicotinic Acetylcholine Receptors Study
- Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Case Reports on Hematomas
Affiliated Hospital of Qingdao University
2015-2022
Qingdao University
2004-2022
The incidence of papillary thyroid microcarcinoma (PTMC) has risen rapidly in recent years, and PTMC patients with central lymph node metastasis (CLNM) usually have poor prognosis. Independent risk factors predicting CLNM not been well understood. aim our study was to identify useful clinicopathological patients. This a retrospective 917 treated surgery from January 2014 December 2015 hospital. relationship between analyzed those PTMC. Univariate multivariate logistic regression analyses...
Background: Papillary thyroid carcinoma (PTC) represents the most frequent subtype of cancer (TC) with poor prognosis mainly due to severe invasion and metastasis. As an oncogene, microRNA-421 (miR-421) is involved in development various cancers. This study was investigate clinical significance miR-421 PTC its effects on biological function cells. Methods: The expression level all tissues cell lines measured by quantitative real-time polymerase chain reaction (qRT-PCR). Subsequently,...
Ribosomal S6 kinase 4 (RSK4) is a putative tumor suppressor gene which inactivated by epigenetic events in number human malignancies; however, its role papillary thyroid carcinoma (PTC) remains largely unknown. The aim of this study was to explore the methylation status RSK4 promoter PTC, and determine potential carcinogenesis. Reverse transcription‑quantitative PCR (RT‑qPCR) western blot analyses were performed examine mRNA protein levels, respectively. Methylation‑specific (MSP) bisulfite...
The incidence of thyroid cancer is increasing rapidly and there an urgent need to explore novel therapeutic targets for cancer. MiR-140 has been reported affect the progression various cancers, which makes it possible play a role in This study aimed investigate expression miR-140 cancer.The was investigated by reverse transcription-quantitative polymerase chain reaction (qRT-PCR) tissues cell lines. prognostic value miR- 140 evaluated Kaplan-Meier survival Cox regression. Moreover, effects...
Papillary thyroid cancer (PTC) is a major kind of with increasing recurrence and metastasis. MiR-127 has been demonstrated to play roles in many cancers dysregulation. However, the function miR-127 still unknown. This study aimed explore novel biomarker for progression prognosis PTC. A set 118 patients PTC were collected from Affiliated Hospital Qingdao University. qRT-PCR was used detect expression tissues cells. The association between clinicopathological features evaluated by χ2 test,...
To evaluate the safety and efficacy of microwave ablation (MWA) versus repeat surgery for treating metastatic lymph nodes (MLNs) in papillary thyroid carcinoma (PTC).Between July 2017 October 2020, 67 patients were enrolled this retrospective study. 19 48 underwent MWA surgery, respectively. The primary secondary endpoints recurrence-free survival complication rates, largest diameter, volume reduction ratio (VRR) analyzed before after MWA. effects different powers on VRR investigated. Pre...
Objective: To investigate the associations between serum uric acid levels during third trimester of pregnancy and risks adverse outcomes. Methods: In this retrospective study, a cohort 7 995 pregnant women who were hospitalized for childbirth from January 2014 to 2019 collected compare outcomes subjects with or without hyperuricemia (HUA). A smooth curve analysis was used evaluate relationship preterm delivery, low birth weight smaller than gestational age. Logistic regression analyses...
To investigate the relationship between methylation of death-associated protein kinase (DAPK) promoter and gene inactivation in papillary thyroid carcinoma, technique methylation-specific polymerase chain reaction (PCR (MSP)) was applied to detect status DAPK 70 cases carcinoma (study group) 50 corresponding adjacent tissues (control group). Immunohistochemical method used expression; besides, with pathological factors cancer analyzed. The rate 16% (8/50) control group 71.4% (50/70) study...
Objective: To investigate the effects of ovarian cancer ascites-derived exosomes on stem cell properties and invasion ability stem-like (OCS-LC). Methods: (1) A2780 cells were induced into OCS-LC in serum-free medium, authenticating their by sphere-forming test, differentiation test CD133 marker detection. (2) Exosomes from ascites extracted ultracentrifugation, then them. The morphology was observed transmission electron microscope, exosome particle size measured nanoparticle tracking...
It was suggested that muscarinic, and nicotinic receptors increase free Ca2+ levels in the facial nerve nucleus via various channels following injury. However, intracellular overload can trigger either necrotic or apoptotic cell death. is assumed that, injury, interactions of muscarinic acetylcholine may negatively regulate concentrations nucleus, which provide important information for repair regeneration nerve. The present study investigated regulatory effects nicotine on receptor-mediated...
Objective To investigate correlative relations between the ultrasonic classification diagnosis and clinicopathological features of thyroid calcification lesions. Methods The clinical data 198 cases diagnosed as lesions by ultrasonic, surgery pathology were retrospectively analyzed. Spearman method was used to analyze relationship TCL diagnosis, pathological traits differentiated carcinoma (DTC). Results Among cases, pathologic accordant in 178 (90.40%)cases. Among 119...