A5041589223- Genetic factors in colorectal cancer
- Cervical Cancer and HPV Research
- BRCA gene mutations in cancer
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cancer survivorship and care
- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Ethics and bioethics in healthcare
- Genital Health and Disease
- Virus-based gene therapy research
- Colorectal and Anal Carcinomas
- COVID-19 Clinical Research Studies
- Reproductive tract infections research
- Prostate Cancer Treatment and Research
- Economic and Financial Impacts of Cancer
Universidad Autónoma de Nuevo León
2016-2025
Hospital Universitario Dr José Eleuterio Gonzalez
2005-2023
MemorialCare Health System
2023
University of Colorado Denver
2016
University of Colorado Cancer Center
2016
Triple-negative breast cancer (TNBC) is an aggressive subtype of tumors. Comparisons between TNBC and non-triple-negative (nTNBC) may help to differentiate key components involved in neoplasms. The purpose the study was analyze expression profile versus nTNBC tumors a homogeneous population from northeastern Mexico. A prospective 50 patients (25 25 nTNBC) conducted. Clinic parameters were equally distributed for nTNBC: age at diagnosis (51 47 years, p = 0.1), glucose level (107 mg/dl 104...
The entire coding regions of BRCA1 and BRCA2 were screened for mutations by heteroduplex analysis in 51 Mexican breast cancer patients. One one truncating mutation each was identi-fied the group 32 (6%) early-onset patients (≤35 years). Besides these two likely deleterious mutations, eight rare variants unknown significance, mostly gene, detected six (19%) cases three 17 (18%) site-specific families, containing a male case. No or sequence have been identified additional families including an...
Pathogenic variants (PVs) of BRCA genes entail a lifetime risk developing breast cancer in 50-85% carriers. Their prevalence different populations has been previously reported. However, there is scarce information regarding the most common PVs these Latin-Americans. This study identified BRCA1 and BRCA2 PV frequency high-risk female population from Northeastern Mexico determined association mutations with patients' clinical pathological characteristics.Women were divided into three groups:...
Hereditary cancer syndromes (HCS) are genetic diseases with an increased risk of developing cancer. This research describes the implementation a prevention model, counseling, and germline variants testing in oncologic center Mexico. A total 315 patients received was offered, 205 individuals were tested for HCS. In 6 years, 131 (63.90%) probands 74 (36.09%) relatives tested. Among probands, we found that 85 (63.9%) had at least one variant. We identified founder mutations BRCA1 novel variant...
Abstract Background Persistent infection with high-risk human papillomavirus (HPV) is a major risk factor for malignant lesions and cervical cancer. A widely studied element in the search genetic factors influencing HPV diseases allelic variation of leukocyte antigen (HLA) locus. The study was designed to HLA susceptibility alleles contributing persistence Mexican women. Methods total 172 subjects were divided into three groups: 1) HPV–persistent patients; 2) HPV–cleared; 3) HPV–reinfected...
Abstract Background: Fluoropyrimidines form the chemotherapy backbone of advanced and metastatic colorectal cancer (CRC). These drugs are frequently associated with toxicity events that result in dose adjustments even suspension treatment. The thymidylate synthase ( Methods: Variants namely rs45445694, rs183205964, rs2853542 rs151264360 Results: 2R/2R (rs45445694) was clinical response (p=0.05, odds ratio (OR)=3.45) severe (p=0.0014, OR=5.21, from pooled data). Expression analysis tumor...
Triple negative breast cancer (TNBC) is a subtype of heterogeneous nature that for estrogen receptor (ER), progesterone (PR) and growth factor human epidermal 2 (HER2) following immunohistochemical analysis. TNBC frequently characterized by relapse reduced survival. To date, there no targeted therapy this type cancer. Chemotherapy, radiotherapy, surgery remain as the standard treatments options. The lack target heterogeneity highlight need to seek new therapeutic In study, fresh tissue...
Neutralizing antibodies (NAs) are key immunological markers and part of the humoral response adaptive immune system. NA assays determine presence functional to prevent SARS-CoV-2 infection. We performed a real-world evidence study detect NAs that confer protection against after application five vaccines (Pfizer/BioNTech, AstraZeneca, Sinovac, Moderna, CanSino) in Mexican population. Side effects COVID-19 clinical demographic factors associated with low immunogenicity were also evaluated. A...
To investigate the association between family history (FH) of neoplasia, gyneco-obstetric factors and breast cancer (BC) in a case-control study. In cases, to analyze those variables relation with early onset BC, manner detection (self-examination, prompted by pain, or casual), size tumor, elapsed time seek medical attention.Data from 151 prevalent BC cases 235 age-matched controls were analyzed multiple logistic regression, assess influence risk factors.Ten per cent patients 1% had...
Peritoneal carcinomatosis refers to a shedding or tumor that spreads the peritoneal serosa and structures of abdominal cavity. It is an entity with poor prognosis. Several conditions can cause this, most common being colon, rectum, ovary, stomach appendix cancers, including pseudomyxoma, among others. The cavity invasion considered clinical stage IV. For long time life expectancy this was very short. With advent meticulous techniques in cytoreductive surgery (CRS) hyperthermic...
Aim: Pharmacogenetic studies in breast cancer (BC) may predict the efficacy of tamoxifen and toxicity paclitaxel capecitabine. We determined frequency polymorphisms CYP2D6 gene associated with activation tamoxifen, those genes CYP2C8, CYP3A5 DPYD also included a IL-10 polymorphism advanced tumor stage at diagnosis. Patients & methods: Genomic DNAs from 241 BC patients northeast Mexico were genotyped using DNA microarray technology. Results: For processing, genotyping predicted that 90.8%...
Objectives To evaluate the usefulness of a negative D-dimer in peripheral or central venous blood to screen for asymptomatic catheter-related thrombosis cancer patients. Methods was measured from catheter and samples 48 patients with cancer. Asymptomatic identified via Doppler ultrasound. Bland Altman’s limits agreement analysis used compare sample sites. Sensitivity specificity calculated. Results Overall, 33 32 had levels below cutoff (≥0.3 mg/l). Mean 0.31 ± 0.35 mg/l; 0.24 0.22 mg/l (p =...
Abstract Background Adiponectin gene ( ADIPOQ ) polymorphisms have been shown to affect adiponectin serum concentration and some associated with breast cancer (BC) risk. The aims of this study were describe the frequency single nucleotide (SNPs) in Mexican women BC determine if they show an association it. Methods DNA samples from 397 patients 355 controls tested for SNPs: rs2241766 (GT) rs1501299 by TaqMan allelic discrimination assay. Hardy–Weinberg equilibrium (HWE) was tested. Multiple...
Breast cancer (BC) has one of the highest incidences and mortality worldwide. Single nucleotide polymorphisms (SNPs) in TOX3 rs3803662 MMP7 rs1943779 have been associated with susceptibility to BC. In this case-control study, we evaluated association (TOX3)/rs1943779 (MMP7) SNPs clinical features, immunohistochemical reactivity, risk BC women from northeastern Mexico. We compared 212 cases controls. DNA was isolated peripheral blood perform polymerase chain reaction-restriction fragment...
<title>Abstract</title> <bold>Background and objective.</bold> The available research on low-dose-rate (LDR) brachytherapy in gynecology cancer has focused mainly treatment toxicity. It does not include aspects such as sexual desire, arousal, orgasm, satisfaction, or quality of life. This study assessed function life before after LDR cervical endometrial patients. We also identified risk factors that contribute to the loss those associated with an improvement 3–6 months...