A5089126801- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Synthesis of β-Lactam Compounds
- Computational Drug Discovery Methods
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Click Chemistry and Applications
- Cardiovascular Disease and Adiposity
- Platelet Disorders and Treatments
- Cancer therapeutics and mechanisms
- Analytical Methods in Pharmaceuticals
- Lung Cancer Diagnosis and Treatment
- Biochemical and Molecular Research
- Viral Infections and Vectors
- Medicinal Plants and Neuroprotection
- Tuberculosis Research and Epidemiology
- Viral Infections and Outbreaks Research
- Central Venous Catheters and Hemodialysis
- Enzyme function and inhibition
- Medicinal Plants and Bioactive Compounds
- Cancer Research and Treatment
- Diabetes Management and Research
- Antibiotic Resistance in Bacteria
- Estrogen and related hormone effects
- Disaster Response and Management
University of Nottingham
2020-2023
United Lincolnshire Hospitals NHS Trust
2020-2021
Pilgrim Hospital
2020-2021
Deutsches Diabetes-Zentrum e.V.
2016
Heinrich Heine University Düsseldorf
2012-2016
Orthopädische Praxis
2015
University of Rostock
2008
The German Diabetes Study (GDS) is a prospective longitudinal cohort study describing the impact of subphenotypes on course disease. GDS aims at identifying prognostic factors and mechanisms underlying development related comorbidities.The comprises intensive phenotyping within 12 months after clinical diagnosis, 5-year intervals for 20 years annual telephone interviews in between. Dynamic tests, including glucagon, mixed meal, intravenous glucose tolerance hyperinsulinemic clamp serve to...
The development of small molecule inhibitors targeting GPVI has promising therapeutic role, as they inhibit arterial thrombosis with limited risk bleeding. Among the compounds showing in vivo antithrombotic activity, most active compound 6b (ED50 = 28.36 μmol/kg po mice) showed improved inhibition for collagen (IC50 6.7 μM), CRP-XL 53.5 and convulxin (CVX) 5.7 μM) mediated platelet aggregation compared to losartan (LOS) (collagen, IC50 10.4 μM; CRP-XL, 158 CVX, 11 than any its enantiomers S...
The world is under the great threat of antimicrobial resistance (AMR) leading to premature deaths. Micro-organisms can produce AMR via quorum sensing mechanisms utilizing S-adenocylhomocystiene/methiothioadenosine nucleosidase (SAH/MTAN) biosynthesis. But there no specific drug developed till date stop theSAH/MTAN which a crucial target for discovery anti compound. It has been shown that indazole compounds causes inhibition SAH/MTA mediated sensing, but biochemical have not yet...
Background and aims : Therapy with NSAIDs may interfere antiplatelet activity of aspirin. The mechanism this drug-drug interaction has not yet been established on the level enzyme kinetics quantitative structure-activity relationship (QSAR). Methods: Time-dependent (log K) for onset COX-1 inhibition was measured 17 common using arachidonic acid-induced (human platelet microsomes, bioluminescence). IC50 values all were determined by thromboxane (TX) formation in rich plasma, as well vitro...
Introduction: With advancement in interventional cardiology an increase the number of percutaneous coronary intervention (PCI) procedures has been noted elderly. However, post procedure complication and mortality remain a challenge for physicians. This study aimed to estimate survival among men women above 80 years age who undergo primary PCI treatment ST elevation myocardial infarction. Methods: We analyzed data collected prospectively from our cardiac center. The patients were followed up...
Introduction: Advancement in interventional cardiology has increased the number of percutaneous coronary intervention (PCI) elderly. However, clinicians still face tough decision making to select elderly patients who can receive Primary PCI and have improved survival. This study aimed identify factors that influence survival population undergoing PPCI for treatment ST elevation myocardial infraction (STEMI). Methods: We analyzed data at our cardiac center prospectively during 2010- 2019...