Lyla A. Youssef

ORCID: 0000-0002-0661-4359
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About
Contact & Profiles
Research Areas
  • Erythrocyte Function and Pathophysiology
  • Blood groups and transfusion
  • Blood transfusion and management
  • Epigenetics and DNA Methylation
  • Iron Metabolism and Disorders
  • Ferroptosis and cancer prognosis
  • Heme Oxygenase-1 and Carbon Monoxide
  • Hemoglobinopathies and Related Disorders
  • Immune cells in cancer
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Phagocytosis and Immune Regulation
  • Mesenchymal stem cell research
  • Cancer-related molecular mechanisms research
  • Immune responses and vaccinations
  • Autophagy in Disease and Therapy

Columbia University
2017-2020

Columbia University Irving Medical Center
2015

Reticuloendothelial macrophages engulf ~0.2 trillion senescent erythrocytes daily in a process called erythrophagocytosis (EP). This critical mechanism preserves systemic heme-iron homeostasis by regulating red blood cell (RBC) catabolism and iron recycling. Although extensive work has demonstrated the various effects on macrophage metabolic reprogramming stimulation with proinflammatory cytokines, little is known about impact of EP metabolome proteome. Thus, we performed mass...

10.3389/fphys.2020.00396 article EN cc-by Frontiers in Physiology 2020-04-30
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