A5090210260- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Pesticide Residue Analysis and Safety
- Analytical Chemistry and Chromatography
- Dendrimers and Hyperbranched Polymers
- Cholesterol and Lipid Metabolism
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Chemical Synthesis and Analysis
Technical University of Munich
2017-2021
Leibniz-Institute for Food Systems Biology at the Technical University of Munich
2019
Max Planck Computing and Data Facility
2017
Starting from multifunctional triazacyclononane-triphosphinate chelator cores, dendritic molecules with the ability to bind metal ions within their framework were synthesized. A cooperative interaction of cages resulted in a markedly increased affinity towards 67/68GaIII. hexameric PSMA inhibitor conjugate high (IC50 = 1.2 nM) and favorable vivo PET imaging properties demonstrated practical applicability. The novel scaffolds are useful for synthesis structurally well-defined multimodal...
Abstract microRNAs (miRNAs) are post-transcriptional regulators involved in many biological processes and human diseases, including cancer. The majority of transcripts compete over a limited pool miRNAs, giving rise to complex network competing endogenous RNA (ceRNA) interactions. Currently, gene-regulatory networks focus mostly on transcription factor-mediated regulation, dedicated efforts for charting ceRNA regulatory scarce. Recently, it became possible infer interactions genome-wide from...
Phytostanyl fatty acid esters, which are being added to a variety of foods owing their cholesterol-lowering properties, susceptible thermally induced oxidation reactions. Using sitostanyl oleate as an example, we, in this study, aimed at developing strategies for the detection and quantitation acyl chain products (ACOPs). The elaborated ultra high performance liquid chromatography-mass spectrometry MS/MS-based approach involves (i) derivatizations hydroxy oxo groups, (ii) combined use...