A5000785252- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- FOXO transcription factor regulation
- Bioinformatics and Genomic Networks
- Amyotrophic Lateral Sclerosis Research
- RNA and protein synthesis mechanisms
- Genetic Neurodegenerative Diseases
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Advanced biosensing and bioanalysis techniques
- Nuclear Receptors and Signaling
- Neuroscience and Neuropharmacology Research
Institute for Stem Cell Biology and Regenerative Medicine
2019
Kennedy Center
2019
John F. Kennedy Center for the Performing Arts
2019
Akebia Therapeutics (United States)
2019
Albert Einstein College of Medicine
2019
Abstract Neuroinflammation is a key driver of neurodegenerative disease, however the tools available to model this disease biology at systems level are lacking. We describe translational drug discovery platform based on organotypic culture murine cortical brain slices that recapitulate disease-relevant neuroinflammatory biology. After an acute injury response, assume chronic state marked by transcriptomic profiles indicative activation microglia and astrocytes loss neuronal function....
Abstract Objective Gain‐of‐function variants in the KCNT1 gene, which encodes a sodium‐activated potassium ion channel, drive severe early onset developmental epileptic encephalopathies including epilepsy of infancy with migrating focal seizures and sleep‐related hypermotor epilepsy. No therapy provides more than sporadic or incremental improvement. Here, we report suppression genetic mouse model by reducing Kcnt1 transcript divalent small interfering RNA (siRNA), an emerging variant...
Emerging studies are providing compelling evidence that the pathogenesis of Huntington's disease (HD), a neurodegenerative disorder with frequent midlife onset, encompasses developmental components. Moreover, our previous using hypomorphic model targeting huntingtin during neurodevelopmental period indicated loss-of-function mechanisms account for this pathogenic component (Arteaga-Bracho et al., 2016). In present study, we specifically ascertained roles subpallial lineage species in...
Transient global ischemia arising in human due to cardiac arrest causes selective, delayed neuronal death hippocampal CA1 and cognitive impairment. Growth DNA-damage-inducible protein 45 beta (Gadd45b) is a wellknown molecule both DNA damage-related pathogenesis therapies. Emerging evidence suggests that Gadd45b an anti-apoptotic factor nonneuronal cells intrinsic neuroprotective neurons. However, the mechanism of pathway not fully examined neurodegeneration associated with ischemia. Rats...
Chronic neuroinflammation is a hallmark of Alzheimer's disease and other neurodegenerative disorders.Microglial dysfunction likely significant contributor to the onset progression disease. The elucidation non-innate immune functions microglia in CNS development have revealed new therapeutic strategies for how microglial function might be modulated protect aging brain. In vitroassays based on isolated do not fully model neuroinflammatory environment that arises during Therefore, predictive...