A5073186051- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Lipid Membrane Structure and Behavior
- Monoclonal and Polyclonal Antibodies Research
- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Pharmaceutical studies and practices
- Immune Cell Function and Interaction
- Advanced Polymer Synthesis and Characterization
- Surfactants and Colloidal Systems
- BIM and Construction Integration
- T-cell and B-cell Immunology
- Food Chemistry and Fat Analysis
- Fluid Dynamics and Heat Transfer
- Electrohydrodynamics and Fluid Dynamics
- Animal Nutrition and Physiology
- Drug Transport and Resistance Mechanisms
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Chromatography
- biodegradable polymer synthesis and properties
- Ocular Surface and Contact Lens
- Lipoproteins and Cardiovascular Health
- Veterinary medicine and infectious diseases
AstraZeneca (Sweden)
2018-2024
Brunel University of London
2021
SPTS Technologies (United Kingdom)
2014
The University of Queensland
2003-2013
University of Otago
1994-2007
Pharmac
2005
University of Wales
1991-1992
Inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduce low-density lipoprotein (LDL) cholesterol and are used for treatment dyslipidemia. Current PCSK9 inhibitors administered via subcutaneous injection. We present a highly potent, chemically modified antisense oligonucleotide (ASO) with potential oral delivery. Past attempts at delivery using earlier-generation ASO chemistries transient permeation enhancers provided encouraging data, suggesting that improving potency the...
Background: Diabetic foot ulcers (DFU) pose a significant health risk in diabetic patients, with insufficient revascularization during wound healing being the primary cause. This study aimed to assess microvessel sprouting and capabilities using vascular endothelial growth factor (VEGF-A) modified fibroblast (FGF1). Methods: An ex vivo aortic ring rodent model an mice were employed evaluate of VEGF-A FGF1 both as monotherapies combination. Results: The combination demonstrated increased...
Existing therapies for rheumatoid arthritis and other autoimmune diseases are not Ag specific, which increases the likelihood of systemic toxicity. We show that egg phosphatidylcholine liposomes loaded with (OVA or methylated BSA) a lipophilic NF-kappaB inhibitor (curcumin, quercetin, Bay11-7082) suppress preexisting immune responses in an Ag-specific manner. injected into mice primed suffering from Ag-induced inflammatory arthritis. The targeted APCs situ, suppressing cells' responsiveness...
Two pseudoternary phase diagrams were constructed using ethyl oleate, water, and a surfactant blend containing poly (oxyethylene 20) sorbitan monooleate monolaurate with or without the cosurfactant 1-butanol. colloidal regions identified in cosurfactant-free diagram; microemulsion (ME) region lamellar liquid crystals (LC). The addition of 1-butanol increased area which systems formed microemulsions eliminated formation any crystalline phases. Samples that form both investigated by...
Fibroblast growth factor 21 (FGF21) is a promising therapeutic agent for treatment of type 2 diabetes (T2D) and non-alcoholic steatohepatitis (NASH). We show that levels FGF21 were achieved following subcutaneous (s.c.) administration mRNA encoding human proteins. The efficacy was assessed 2-weeks repeated s.c. dosing in diet-induced obese (DIO), mice which resulted marked decreases body weight, plasma insulin levels, hepatic steatosis. Pharmacokinetic/pharmacodynamic (PK/PD) modelling...
The effects of chemical enhancers and sonophoresis on the transdermal permeation tizanidine hydrochloride (TIZ) across mouse skin were investigated. Parameters including drug solubility, apparent partition coefficient (APC), permeation, degradation in determined. Low frequency ultrasound was also applied presence absence to assess whether improved. APC values indicated that TIZ preferentially partitions into intercellular spaces does not form a reservoir, with exhibiting good enzymatic...
In this work, we set out to better understand how the permeation enhancer sodium caprate (C10) influences intestinal absorption of macromolecules. FITC-dextran 4000 (FD4) was selected as a model compound and formulated with 50–300 mM C10. Absorption studied after bolus instillation liquid formulation duodenum anesthetized rats intravenously reference, whereafter plasma samples were taken analyzed for FD4 content. It found that AUC Cmax increased increasing C10 concentration. Higher...