A5051594510- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Viral gastroenteritis research and epidemiology
- Respiratory and Cough-Related Research
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Child Nutrition and Feeding Issues
- Food Safety and Hygiene
- Pharmaceutical studies and practices
- Otolaryngology and Infectious Diseases
- Infectious Diseases and Tuberculosis
- Streptococcal Infections and Treatments
Hospital Regional Universitario de Málaga
2017-2024
Instituto de Investigación Biomédica de Málaga
2017-2018
Hospital Universitario Virgen del Rocío
2011
Summary Background The peach non‐specific lipid transfer protein, Pru p 3, is the primary sensitizer in fruits and responsible for severe reactions Mediterranean area. Peach allergy frequently associated with other allergies such as peanut. Therefore , it important to assess how specific immunotherapy 3 could affect both peanut tolerance. Objectives To evaluate desensitization immunological changes after 1 year of sublingual ( SLIT ) patients systemic allergic and/or Methods Forty‐eight...
Allergic rhinitis (AR) and local allergic (LAR) are defined by nasal reactivity to aeroallergens with without positive skin prick test (SPT), respectively. In this study, we aimed investigate whether both types of allergen-specific can coexist in the same individual.Forty-eight patients perennial symptoms SPT seasonal allergens only (discrepant group) were subjected consecutive allergen challenges (NAC) (NAC-S) (NAC-P). A lavage was collected before after NACs measure eosinophil cationic...
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequent triggers of drug hypersensitivity with NSAIDs-induced urticaria/angioedema (NIUA) common phenotype. Loss has been reported for IgE-mediated reactions; however, it not assessed in nonimmunological reactions such as NIUA. We evaluated NSAID-hypersensitivity over time NIUA patients.Patients confirmed by positive provocation test (DPT) acetylsalicylic acid (ASA) during 2005-2012 (V1) were included (n=38). Subjects prospectively...
Scope Sublingual immunotherapy using peach extract enriched in Pru p 3 (Pru 3‐enriched‐SLIT) brings a new perspective to treating patients with allergy lipid transfer proteins. We evaluate the immunological changes induced by 3‐enriched‐SLIT during one year. Methods and results Three groups are included: allergic who receive 3‐enriched‐SLIT, untreated patients, controls. Peripheral blood mononuclear cells obtained before treatment at different time‐points. Monocyte‐derived dendritic (moDCs)...
Three allergic phenotypes of rhinitis have been described in adults: (AR), local (LAR), and dual (DAR, coexistence AR LAR). Nevertheless, most centers follow a diagnostic approach only based on skin prick test serum allergen-specific IgE (collectively called atopy tests, AT). This prevents the recognition LAR DAR, diagnosis which requires nasal allergen challenge (NAC). Here, we investigate existence DAR children adolescents, misdiagnosis rate associated with work-up exclusively AT.Clinical...
Abstract Introduction Mild non‐immediate reactions (NIRs) to beta‐lactams (BLs) are the most frequent manifestation of drug allergy in children. The diagnostic approach is complex as utility skin tests (STs) and lymphocyte transformation (LTTs) controversial. Drug provocation test (DPT) gold standard, although no standardized protocols exist. We aimed investigate DPT a unique dose without previous STs, LTTs diagnosis NIRs BLs Methods prospectively evaluated children 0–14 years old referred...
Background Oral food challenge (OFC) is the gold standard for diagnosis of acute Food Protein-Induced Enterocolitis Syndrome (FPIES). No diagnostic/prognostic biomarkers are available, and OFC assessment criteria not validated. Objective. To assess clinical-haematological changes predictors severity FPIES reactions at OFC. Methods Observational multicentre prospective study. Children aged 0-18 years diagnosed with were recruited follow-up in 12 tertiary centres Spain Italy. Outcomes (as...
ABSTRACT Background Food protein‐induced enterocolitis syndrome (FPIES) is a food allergy primarily affecting infants, often leading to vomiting and shock. Due its poorly understood pathophysiology lack of specific biomarkers, diagnosis frequently delayed. Understanding FPIES genetics can shed light on disease susceptibility pathophysiology—key developing diagnostic, prognostic, preventive therapeutic strategies. Using well‐characterised cohort patients we explored the potential genome‐wide...