A5028404708- Epigenetics and DNA Methylation
- Gut microbiota and health
- Cancer Cells and Metastasis
- Cancer Research and Treatments
University of Virginia
2021-2022
Establishing commensal dysbiosis, defined as an inflammatory gut microbiome with low biodiversity, before breast tumor initiation, enhances early dissemination of hormone receptor-positive (HR+) mammary cells. Here, we sought to determine whether cellular changes occurring in normal tissues, initiation and response enhanced HR+ tumors. Commensal dysbiosis increased both the frequency profibrogenicity mast cells normal, non-tumor-bearing a phenotypic change that persisted after implantation....
Supplementary Figure from Reciprocal Interactions Between the Gut Microbiome and Mammary Tissue Mast Cells Promote Metastatic Dissemination of HR<sup>+</sup> Breast Tumors
Supplementary Figure from Reciprocal Interactions Between the Gut Microbiome and Mammary Tissue Mast Cells Promote Metastatic Dissemination of HR<sup>+</sup> Breast Tumors
<div>Abstract<p>Establishing commensal dysbiosis, defined as an inflammatory gut microbiome with low biodiversity, before breast tumor initiation, enhances early dissemination of hormone receptor–positive (HR<sup>+</sup>) mammary cells. Here, we sought to determine whether cellular changes occurring in normal tissues, initiation and response enhanced HR<sup>+</sup> tumors. Commensal dysbiosis increased both the frequency profibrogenicity mast cells normal,...
<div>Abstract<p>Establishing commensal dysbiosis, defined as an inflammatory gut microbiome with low biodiversity, before breast tumor initiation, enhances early dissemination of hormone receptor–positive (HR<sup>+</sup>) mammary cells. Here, we sought to determine whether cellular changes occurring in normal tissues, initiation and response enhanced HR<sup>+</sup> tumors. Commensal dysbiosis increased both the frequency profibrogenicity mast cells normal,...
Abstract Establishing commensal dysbiosis, defined as an inflammatory gut microbiome with low biodiversity, prior to breast tumor initiation, enhances early dissemination of hormone-receptor positive (HR + ) mammary cells. Here, we sought define tissue mediators dysbiosis-induced dissemination. We found that dysbiosis increased both the frequency and profibrogenicity mast cells in tissue, a phenotypic change persisted after implantation. Fibroblast activation remodeling associate enhanced...