A5036669112- Gut microbiota and health
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Immune Response and Inflammation
- Inflammatory Biomarkers in Disease Prognosis
- Autophagy in Disease and Therapy
- Angiogenesis and VEGF in Cancer
- CAR-T cell therapy research
- Chemokine receptors and signaling
University of Virginia
2021-2025
University of Virginia Medical Center
2025
A. Alfred Taubman Health Care Center
2020
University of Michigan
2020
Abstract Strategies that interfere with the binding of receptor programmed cell death protein-1 (PD-1) to ligand-1 (PD-L1) have shown marked efficacy against many advanced cancers, including those are negative for PD-L1. Precisely why patients PD-L1 tumors respond PD-1/PD-L1 checkpoint inhibition remains unclear. Here, we show platelet-derived regulates growth and interference platelet cancer cells promotes T cell-induced cytotoxicity. These results suggest successful outcomes based...
Lymph nodes (LNs) are common sites of metastatic invasion in breast cancer, often preceding spread to distant organs and serving as key indicators clinical disease progression. However, the mechanisms cancer cell into LNs not well understood. Existing vivo models struggle isolate specific impacts tumor-draining lymph node (TDLN) milieu on due coevolving relationship between TDLNs upstream tumor. To address these limitations, we used live ex LN tissue slices with intact chemotactic function...
Abstract Ovarian cancer accounts for more deaths than any other of the female reproductive system. Patients who have ovarian tumors infiltrated with high frequencies T cells are associated a greater survival probability. However, therapies to revitalize tumor-associated cells, such as PD-L1/PD-1 or CTLA4 blockade, ineffective treatment cancer. In this study, we demonstrate that cancer, Toll-Like Receptor 5 (TLR5) signaling, which only known ligand is bacterial flagellin, governed failure...
Establishing commensal dysbiosis, defined as an inflammatory gut microbiome with low biodiversity, before breast tumor initiation, enhances early dissemination of hormone receptor-positive (HR+) mammary cells. Here, we sought to determine whether cellular changes occurring in normal tissues, initiation and response enhanced HR+ tumors. Commensal dysbiosis increased both the frequency profibrogenicity mast cells normal, non-tumor-bearing a phenotypic change that persisted after implantation....
Lymph nodes (LNs) are common sites of metastatic invasion in breast cancer, often preceding spread to distant organs and serving as key indicators clinical disease progression. However, the mechanisms cancer cell into LNs not well understood. Existing vivo models struggle isolate specific impacts tumor-draining lymph node (TDLN) milieu on due co-evolving relationship between TDLNs upstream tumor. To address these limitations, we used live ex LN tissue slices with intact chemotactic function...
Supplementary Figure from Reciprocal Interactions Between the Gut Microbiome and Mammary Tissue Mast Cells Promote Metastatic Dissemination of HR<sup>+</sup> Breast Tumors
Supplementary Figure from Reciprocal Interactions Between the Gut Microbiome and Mammary Tissue Mast Cells Promote Metastatic Dissemination of HR<sup>+</sup> Breast Tumors
<div>Abstract<p>Establishing commensal dysbiosis, defined as an inflammatory gut microbiome with low biodiversity, before breast tumor initiation, enhances early dissemination of hormone receptor–positive (HR<sup>+</sup>) mammary cells. Here, we sought to determine whether cellular changes occurring in normal tissues, initiation and response enhanced HR<sup>+</sup> tumors. Commensal dysbiosis increased both the frequency profibrogenicity mast cells normal,...
<div>Abstract<p>Establishing commensal dysbiosis, defined as an inflammatory gut microbiome with low biodiversity, before breast tumor initiation, enhances early dissemination of hormone receptor–positive (HR<sup>+</sup>) mammary cells. Here, we sought to determine whether cellular changes occurring in normal tissues, initiation and response enhanced HR<sup>+</sup> tumors. Commensal dysbiosis increased both the frequency profibrogenicity mast cells normal,...
Abstract Ovarian cancer accounts for more deaths than any other of the female reproductive system. Patients bearing ovarian tumors infiltrated with high frequencies T cells associate a greater survival probability. However, therapies targeting in cancers are ineffective. We observed models late-stage murine that absence Toll-Like Receptor 5 (TLR5) signaling, anti-PD-L1 promotes significant and protection against tumor rechallenge. from rechallenged TLR5KO mice exhibited significantly higher...
Abstract Hormone receptor-positive (HR +), HER2 −is the most prevalent metastatic breast cancer subtype, constituting 73.1% of disease population in US. Despite targeted therapies that have increased long-term survival, many patients develop and eventually succumb to disease. Tumor dissemination occurs early during progression is driven by cellular molecular changes tissue. Though host-intrinsic factors preferentially predispose certain individuals are poorly defined, gut microbial health...
Abstract Ovarian cancer accounts for more deaths than any other of the female reproductive system. Patients bearing ovarian tumors infiltrated with high frequencies T cells associate a greater survival probability. However, therapeutic strategies targeting in cancers are largely ineffective. We have observed our models late-stage murine that absence Toll-Like Receptor 5 (TLR5) signaling, anti-PD-L1 therapy promotes significant and subsequent protection against tumor rechallenge. from...
Abstract Establishing commensal dysbiosis, defined as an inflammatory gut microbiome with low biodiversity, prior to breast tumor initiation, enhances early dissemination of hormone-receptor positive (HR + ) mammary cells. Here, we sought define tissue mediators dysbiosis-induced dissemination. We found that dysbiosis increased both the frequency and profibrogenicity mast cells in tissue, a phenotypic change persisted after implantation. Fibroblast activation remodeling associate enhanced...