A5057560085- Protein Interaction Studies and Fluorescence Analysis
- Nanoparticle-Based Drug Delivery
- Blood properties and coagulation
- Iron Metabolism and Disorders
- Erythropoietin and Anemia Treatment
- Nanoplatforms for cancer theranostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Polymer Surface Interaction Studies
- Nanocluster Synthesis and Applications
- Platelet Disorders and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Universidade Federal de São Paulo
2023-2024
To date, much effort has been devoted toward the study of protein corona formation onto large gold nanoparticles (GNPs). However, concept breaks down for GNPs in ultrasmall size regime (<3 nm), and, as a result, our understanding GNP (usGNP)-protein interactions remains incomplete. Herein, we used anionic usGNPs and six different proteins model systems to systematically investigate usGNP-protein interactions, with particular focus on time evolution long-term behavior complex formation. The...
Engineered nanoparticles (NPs) have the potential to revolutionize disease diagnostics and treatment. However, NP interactions with proteins in biological fluids complicate their vivo control. These often lead formation of protein coronas around surface, shaping fate behavior within systems. To harness full NPs biomedical applications, it is therefore essential gain a comprehensive understanding proteins. Within this context, must be recognized that traditional equilibrium-based descriptions...
Albumin-based nanoparticles (ABNPs) represent promising drug carriers in nanomedicine due to their versatility and biocompatibility, but optimizing effectiveness delivery requires understanding interactions with uptake by cells. Notably, albumin interacts the cellular glycocalyx, a phenomenon particularly studied endothelial This observation suggests that glycocalyx could modulate ABNP therapeutic efficacy, although this possibility remains unrecognized. In study, we elucidate critical role...
Abstract The formation of a proper fibrin clot is essential during blood coagulation, as abnormal clots can predispose individuals to bleeding or thrombosis. Despite these concerns, there currently limited understanding the potential adverse effects engineered nanomaterials on formation. This surprising, given that fibrinogen highly concentrated in plasma and has large surface area, making it prone unintended interactions with nanomaterials. In this study, impact ultrasmall gold...