A5047698046- TGF-β signaling in diseases
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Endometriosis Research and Treatment
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Fungal Biology and Applications
- Prostate Cancer Treatment and Research
- Reproductive System and Pregnancy
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Ginseng Biological Effects and Applications
- Wnt/β-catenin signaling in development and cancer
- S100 Proteins and Annexins
- Kruppel-like factors research
- HER2/EGFR in Cancer Research
- Metabolism, Diabetes, and Cancer
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Amyotrophic Lateral Sclerosis Research
- Growth Hormone and Insulin-like Growth Factors
- Medicinal Plant Pharmacodynamics Research
The University of Texas Health Science Center at San Antonio
2016-2025
The University of Texas Health Science Center at Houston
2020-2025
Bridge University
2024
Audie L. Murphy Memorial VA Hospital
2021
Philadelphia University
2009
University of Pennsylvania
2009
Uterine fibroids (UFs) are the most common non-cutaneous tumors in women worldwide. UFs arise from genetic alterations myometrial stem cells (MM SCs) that trigger their transformation into tumor-initiating (UF SCs). Mutations RNA polymerase II Mediator subunit MED12 dominant drivers of UFs, accounting for 70% these clinically significant lesions. Biochemically, UF driver mutations disrupt CDK8/19 kinase activity Mediator, but how disruption triggers MM SC remains unknown. Here, we show...
It has been recently demonstrated that progranulin is overexpressed in ovarian cancer and this protein involved the stimulation of cell proliferation, malignancy, chemoresistance cancer. The goal present study was to establish differences expression among normal, benign, malignant tissues identify signal transduction pathways activated by an line. Compared with benign tumors normal tissue, mRNA were tumors. Survival analysis Kaplan-Meier method showed a correlation between high levels poor...
The effects of transforming growth factor beta (TGF-β) signaling on prostate tumorigenesis has been shown to be strongly dependent the stage development, with TGF-β functioning as a tumor suppressor in early stages disease and promoter later stages. To study further detail paradoxical tumor-suppressive tumor-promoting roles pathway, we investigated effect systemic treatment inhibitor tumorigenesis. ensure effective inhibition, developed employed novel trivalent receptor trap, RER, comprised...
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Binding Properties of the Transforming Growth Factor-β Coreceptor Betaglycan: Proposed Mechanism for Potentiation Receptor Complex Assembly and SignalingMaria M. VillarrealMaria VillarrealMore by Maria Villarreal, Sun Kyung KimSun KimMore Kim, Lindsey BarronLindsey BarronMore Barron, Ravi KodaliRavi KodaliMore Kodali, Jason BaardsnesJason BaardsnesMore Baardsnes, Cynthia S....
To identify, in myometrial stem/progenitor cells, the presumptive cell of origin for uterine fibroids, substrates Mediator-associated cyclin dependent kinase 8/19 (CDK8/19), which is known to be disrupted by fibroid driver mutations Mediator complex subunit 12 (MED12).
Ewing sarcoma is a cancer of the bone and soft tissue that primarily affects children, adolescents, young adults. The current standard care for includes surgical resection, radiotherapy, chemotherapy. 5-year survival rate 70-80% those with localized disease 20-30% patients metastatic or recurrent disease. Although prognosis good disease, there remains need development alternative treatment approaches Furthermore, toxicity associated radio chemotherapy undesirable especially considering these...
Ewing Sarcoma is a highly aggressive pediatric bone and soft tissue malignancy. Current treatment strategies for involve combination of surgery, radiation therapy, chemotherapeutic agents. These are effective patients with localized disease, as 70-80% these survive. However, the prognosis remains unfavorable those metastatic or recurrent only 20-30% Thus, there need development alternative therapeutic approaches to treat patients. The objective this study, was investigate anti-proliferative...
P53 is a globular protein with distinct domains and key tumor suppressor that functions through transcriptional transactivation, repression protein-protein interactions. Numerous studies have implicated interactions between p53 multitude of cellular proteins variety known functions. Because these interactions, the many gene expression regulations, potential mechanisms their relationship to suppression been proposed. It desirable test in an vitro setting demonstrate any identified interaction...
Colorectal cancer (CRC) is the second and third most commonly diagnosed in women men, respectively. Few treatment options exist for advanced stage disease, thus, development of targeted therapies crucial treatment. The canonical wingless related integration site (WNT)/β‐CATENIN pathway a driver >90% CRCs. mediator kinase module (mediator complex subunit 12 (MED12), 13 (MED13), CYCLIN C, cyclin dependent 8 (CDK8)) key node oncogenic activation within WNT/β‐CATENIN pathway, since β‐CATENIN...
Uterine fibroids are benign tumors that occur in the myometrium of uterus. Although they benign, represent a significant health problem as affect approximately 70% women and cause pregnancy complications, infertility menstrual disorders. These issues especially concerning uterine reproductive age. To date, non-invasive, long-term treatment options for not available. Thus, need remains to develop non-invasive fibroids. Strikingly, have mutations protein called MED12. MED12 is one 3 proteins...