A5049920246- Drug Transport and Resistance Mechanisms
- Banana Cultivation and Research
- Epigenetics and DNA Methylation
- Genomics, phytochemicals, and oxidative stress
- DNA and Nucleic Acid Chemistry
- Biological Research and Disease Studies
- Neuroscience and Neuropharmacology Research
- Renal and related cancers
- Enzyme function and inhibition
- Cancer therapeutics and mechanisms
- Rural Development and Agriculture
- Acute Myeloid Leukemia Research
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Metal complexes synthesis and properties
- Macrophage Migration Inhibitory Factor
- DNA Repair Mechanisms
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Agricultural and Food Sciences
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Cell death mechanisms and regulation
- Growth and nutrition in plants
- Genetic factors in colorectal cancer
Universidade Federal do Rio Grande
2014-2024
Western University
2020
Universidade Federal do Rio Grande do Sul
2014
Precursor B cell acute lymphoblastic leukemia (B-ALL) is caused by genetic lesions in developing cells that function as drivers for the accumulation of additional mutations an evolutionary selection process. We investigated secondary leukemogenesis a mouse model B-ALL driven PU.1/Spi-B deletion (Mb1-CreΔPB). Whole-exome-sequencing analysis revealed recurrent Jak3 (encoding Janus kinase 3), Jak1, and Ikzf3 Aiolos). Mutations with high variant-allele frequency (VAF) were dominated C→T...
In the present study, molecular docking mechanism based on pharmacodynamic interactions between ligands AZD1208 and recognized chemotherapy agents (Vincristine Daunorubicin) with human ATP-binding cassette (ABC) transporters (ABCB1) was investigated. For first time, were combined an in silico approaches like ab initio computational simulation Density Functional Theory (DFT) to explain drug-drug interaction of aforementioned transmembrane ligand extrusion binding domains (TMDs) ABCB1. this...
PIM-1 is a kinase which has been related to the oncogenic processes like cell survival, proliferation, and multidrug resistance (MDR). This known for its ability phosphorylate main extrusion pump (ABCB1) MDR phenotype.In present work, we tested new mechanistic insight on AZD1208 (PIM-1 specific inhibitor) under interaction with chemotherapy agents such as Daunorubicin (DNR) Vincristine (VCR).In order verify potential cytotoxic effect based pharmacological synergism, two lines were used:...
We aimed to find new therapeutic targets related Cancer Stem Cell alterations in recurrent patients from two TCGA cohorts: Testicular Germ Tumor (TGCT) and Uterine Corpus Endometrial Carcinoma (UCEC). Raw sequencing data were downloaded the database. Datasets containing RNA expression Methylation files directly cBioportal. Variant Call Format (VCFs) GDC portal. Gene enrichment analysis was performed using GSEA (Gene Set Enrichment Analysis) software. Transcriptome profiling, coexpression...
Os distúrbios oftalmológicos atingem grande parte da população brasileira, principalmente os idosos. Tais acometimentos, possuem maior incidência em pacientes com comorbidades associadas, como a diabetes mellitus (DM). A exemplo disso, cita-se retinopatia diabética (RD), complicação microvascular que atinge mais de um terço das pessoas DM. Essa revisão objetiva entender associação mellitus, bem seu tratamento. Assim sendo, foram realizadas pesquisas nos bancos dados PubMed, LILACS e SciELO...
Abstract In this work, we identified that different chemotherapeutic drugs may select cells with antioxidant capacities. For this, evaluated the sensitivity of two multidrug-resistant (MDR) erythroleukemia cell lines: Lucena (resistant to vincristine, VCR) and FEPS daunorubicin, DNR) derived from same sensitive K562 (non-MDR) hydrogen peroxide. addition, how lines respond oxidizing agent in absence VCR/DNR. VCR, drastically decreases viability when exposed peroxide, while is not affected...