A5043573817- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Animal Genetics and Reproduction
- Phytase and its Applications
- Invertebrate Immune Response Mechanisms
- Drug Transport and Resistance Mechanisms
- Zebrafish Biomedical Research Applications
- Protein Hydrolysis and Bioactive Peptides
- Insect behavior and control techniques
- Environmental Sustainability and Education
- Mosquito-borne diseases and control
- Plant and animal studies
- Muscle Physiology and Disorders
- Metal complexes synthesis and properties
- Myxozoan Parasites in Aquatic Species
- HIV/AIDS drug development and treatment
- Venomous Animal Envenomation and Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Aquatic life and conservation
- Heat shock proteins research
- Enzyme Production and Characterization
- Cancer Mechanisms and Therapy
- Pharmacological Effects and Toxicity Studies
- Glutathione Transferases and Polymorphisms
- Fish biology, ecology, and behavior
Universidade Federal do Rio Grande
2015-2025
University of Rio Grande and Rio Grande Community College
2010-2022
Universidade Federal do Rio Grande do Sul
2009-2013
Intestinal permeability plays a crucial role in intestinal barrier function. Altered is well documented numerous chronic diseases and may serve as risk factor for disease onset target innovative therapeutic strategies. While reliable sensitive approaches studying have been established animal models, such mice zebrafish larvae, methods investigating this adult remain considerable challenge. The has emerged valuable model development, physiology, disease. Moreover, offer certain advantages...
White spot syndrome virus (WSSV) and Infectious hypodermal hematopoietic necrosis (IHHNV) are two infectious agents associated to economic losses in shrimp aquaculture. As spread occurs through vectors hosts, this study sought verify the presence of WSSV IHHNV Neohelice granulata crab from Lagoa dos Patos estuary Brazil nearby farms. DNA extractions were performed with phenol/chloroform protocol. Molecular diagnosis was carried out by nested PCR for one-step IHHNV. Results showed on crabs...
Transgenic fish for growth hormone (GH) has been considered as a potential technological improvement in aquaculture. In this study, double-transgenic zebrafish was used to evaluate the effect of GH and its receptor (GHR) on muscle growth. Double transgenics reached same length transgenic, but with significantly less weight, featuring an unbalanced The condition factor GH/GHR-transgenic lower than other genotypes. Histological analysis showed decrease percentage thick fibers GH/GHR genotype...
In the present study, molecular docking mechanism based on pharmacodynamic interactions between ligands AZD1208 and recognized chemotherapy agents (Vincristine Daunorubicin) with human ATP-binding cassette (ABC) transporters (ABCB1) was investigated. For first time, were combined an in silico approaches like ab initio computational simulation Density Functional Theory (DFT) to explain drug-drug interaction of aforementioned transmembrane ligand extrusion binding domains (TMDs) ABCB1. this...
We provide ultrastructural and cytological evidence that the tentacles of sea anemone Bunodosoma cangicum does not contain cytotoxic venom. However, we show stimulated secretion an apparent mixture biomolecules containing polypeptides from columnar vesicles is apparently a potent inducer apoptosis in zebrafish cell line, ZF-L. Microscopic fluorescence, morphology flow cytometric assays confirm apoptotic activity. Crude vesicle venom was partially purified by size exclusion chromatography....
Graphical Abstract GH overexpression increases the intestinal mass and absorptive surface area both through direct effects of transgenics (up-regulating expression its cognate receptor insulin-like growth factor, igf1a ) indirect an increase in amount food consumed. In addition, hyperphagia provides a greater nutrients lumen stimulates synthesis di- tri-peptide transporters, which are main route absorption dietary products from protein degradation.
Abstract Cryptic species represent a substantial fraction of the diversity Drosophilidae, hampering studies on ecologies and their evolution. Anthophilous within Drosophila lutzii group encompass some most widely distributed Neotropical lineages. Nevertheless, ranges, ecologies, divergence times, phylogenetic relationships are largely unknown. In this study, we analyzed cryptic complex occurring in Southern Brazil shed light ecological evolutionary processes underlying current patterns...
PIM-1 is a kinase which has been related to the oncogenic processes like cell survival, proliferation, and multidrug resistance (MDR). This known for its ability phosphorylate main extrusion pump (ABCB1) MDR phenotype.In present work, we tested new mechanistic insight on AZD1208 (PIM-1 specific inhibitor) under interaction with chemotherapy agents such as Daunorubicin (DNR) Vincristine (VCR).In order verify potential cytotoxic effect based pharmacological synergism, two lines were used:...
Abstract Saponins are amphipathic glycosides with detergent properties present in vegetables. These compounds, when ingested, can cause difficulties absorbing nutrients from food and even induce inflammatory processes the intestine. There is already some evidence that saponins be degraded by β-glucosidases of GH3 family. In study, we evaluated, through computational tools, possibility a β-glucosidase (AMBGL17) obtained metagenomic analysis Amazonian soil, to catalytically interact saponin...
Currently, in Brazil, all researchers involved animal experimentation must undergo training laboratory science to stay updated on biology, methodology, ethics, and legal considerations related the use of animals. The program presented this study not only aims fulfill a obligation but also intends train students professionals effectively care for their biomodels. It seeks help them understand importance care, both welfare animals results projects. In total, 58 participants were present at...
The Zygothrica genus group has been shown to be speciose, with a high number of cryptic species. DNA barcoding approaches have valuable tool uncover diversity in this lineage, as recently suggested for the Neotropical Mycodrosophila projectans complex, which seems comprise at least three different aim study was confirm subdivision M . complex while shedding some light on patterns and processes related its diversification. In sense, use single multi-locus datasets under phylogenetic,...