A5000023122- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Voice and Speech Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Dysphagia Assessment and Management
- Esophageal and GI Pathology
- Cardiovascular Disease and Adiposity
- Head and Neck Surgical Oncology
- Extracellular vesicles in disease
- Trauma Management and Diagnosis
- Congenital Diaphragmatic Hernia Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Foreign Body Medical Cases
- Vascular Anomalies and Treatments
- Medical Practices and Rehabilitation
- Congenital heart defects research
- Interpreting and Communication in Healthcare
- Oropharyngeal Anatomy and Pathologies
- RNA modifications and cancer
- Proteoglycans and glycosaminoglycans research
- Nasal Surgery and Airway Studies
Medical University of Vienna
2018-2025
University of Colorado Anschutz Medical Campus
2024
Ludwig Boltzmann Institute for Lung Vascular Research
2024
Stanford University
2024
University of Colorado Denver
2024
German Center for Lung Research
2024
Cardio-Pulmonary Institute
2024
Justus-Liebig-Universität Gießen
2024
Medical University of Graz
2024
Universitätsklinik für Chirurgie Wien
2018
Changes in the extracellular matrix of pulmonary arteries (PAs) are a key aspect vascular remodeling hypertension (PH). Yet, our understanding alterations affecting proteoglycan (PG) family remains limited. We sought to investigate expression and spatial distribution major PGs PAs from healthy individuals various PH groups (chronic obstructive disease: PH-COPD, fibrosis: PH-PF, idiopathic: IPAH). PG regulation, deposition, synthesis were notably heightened IPAH, followed by with minor...
Pulmonary fibrosis (PF) can be a fatal disease characterized by progressive lung scarring. It is still poorly understood how the pulmonary endothelium involved in pathogenesis. Differences of vasculature between patients and donors were analyzed using transmission electron microscopy, immunohistochemistry, single-cell RNA sequencing. Vascular barrier resistance, endothelial-immune cell adhesion, sensitivity to an inflammatory milieu studied
Pulmonary vascular remodeling is a progressive pathological process characterized by functional alterations within pulmonary artery smooth muscle cells (PASMC) and adventitial fibroblasts (PAAF). Mechanisms driving the transition to diseased phenotype remain elusive. Utilizing combination of transcriptomic proteomic profiling, along with phenotyping source-matched from healthy controls individuals idiopathic arterial hypertension (IPAH), our investigation uncovered that while PASMC PAAF...
Background: Pulmonary vascular remodeling is a progressive pathological process characterized by functional alterations within pulmonary artery smooth muscle cells (PASMCs) and adventitial fibroblasts (PAAFs). Mechanisms driving the transition to diseased phenotype remain elusive. Methods: We combined transcriptomic proteomic profiling with phenotypic characterization of source-matched from healthy controls individuals idiopathic arterial hypertension (IPAH). Bidirectional cellular crosstalk...
Surgical treatment for airway stenosis necessitates personalized techniques based on the location and length, leading to favourable surgical outcomes. However, there is limited literature functional outcomes following laryngotracheal surgery with an adequate number of patients.
Abstract OBJECTIVES A tension-free anastomosis is crucial to minimize the risk of airway complications after laryngotracheal surgery. The ‘guardian’ chin stitch placed prevent hyperextension neck in early postoperative period. This manoeuvre was introduced tracheal surgery and now routinely performed by many surgeons. However, evidence for or against sparse. METHODS We a retrospective analysis all adult patients receiving (laryngo-)tracheal resection at our department from October 2011...
Abstract OBJECTIVES Compared to lung resections, airway procedures are relatively rare in thoracic surgery. Despite this, a growing number of dedicated centres have formed throughout Europe. These characterized by close interdisciplinary collaboration and they often act as supra-regional referring centres. To date, most evidence surgery comes from retrospective, single-centre analysis there is lack large-scale, multi-institutional databases. METHODS In 2018, an initiative was formed, which...
Summary Pulmonary vascular remodeling is a progressive pathological process characterized by functional alterations within pulmonary artery smooth muscle cells (PASMC) and adventitial fibroblasts (PAAF). Mechanisms driving the transition to diseased phenotype remain elusive. Utilizing combination of transcriptomic proteomic profiling, along with phenotyping source-matched from healthy controls individuals idiopathic arterial hypertension (IPAH), our investigation uncovered that while PASMC...
Pulmonary vascular remodeling is a progressive pathological process characterized by functional alterations within pulmonary artery smooth muscle cells (PASMC) and adventitial fibroblasts (PAAF). Mechanisms driving the transition to diseased phenotype remain elusive. Utilizing combination of transcriptomic proteomic profiling, along with phenotyping source-matched from healthy controls individuals idiopathic arterial hypertension (IPAH), our investigation uncovered that while PASMC PAAF...
Tracheobronchial injury is a rare but potentially life-threatening condition. Various surgical treatment options have been described for symptomatic patients with full-thickness injury. However, studies comprising meaningful number of are sparse.We retrospectively analyzed all who received repair tracheobronchial between January 1999 and May 2021 at the Department Thoracic Surgery, Medical University Vienna. Patient characteristics, variables, postoperative morbidity, mortality were...
The treatment of benign subglottic stenoses can be challenging. It requires an experienced multidisciplinary team. is important to define the aetiology, severity and number/types any pretreatments stenosis. Short-term symptom relief achieved with endoscopic techniques; however, this comes at price a high likelihood restenosis, which often more severe than original Successful long-term stenosis by surgical resection in most cases. Cricotracheal established standard technique treat In patients...
Abstract OBJECTIVES Treatment options for benign subglottic stenosis include endoscopic techniques or open surgery. Although treatment is less invasive, a considerable proportion of patients develop recurrent stenosis. Endoscopic pretreatments do not exclude from later surgical repair; however, the impact previous attempts on functional outcome after surgery unknown. METHODS All patients, who received cricotracheal resection (CTR) between January 2017 and June 2023 at Department Thoracic...
Pulmonary vascular remodeling is a progressive pathological process characterized by functional alterations within pulmonary artery smooth muscle cells (PASMC) and adventitial fibroblasts (PAAF). Mechanisms driving the transition to diseased phenotype remain elusive. Utilizing combination of transcriptomic proteomic profiling, along with phenotyping source-matched from healthy controls individuals idiopathic arterial hypertension (IPAH), our investigation uncovered that while PASMC PAAF...
Cricotracheal resection (CTR) is considered the standard of care for patients suffering from idiopathic subglottic stenosis (iSGS). Although CTR results in permanent restoration airway patency, it has a mild to moderate impact on voice quality. Here we propose modifications technique make voice-preserving procedure.
Der funktionelle Erhalt der Larynxfunktionen – Deglutition, Atmung und Stimme ist die oberste Zielsetzung bei laryngotrachealen Eingriffen. In Literatur finden sich allerdings kaum Daten über Lebensqualität nach Eingriffen, Veränderung Larynx-Funktionalität beschreiben.
Idiopathic subglottic stenosis is a rare disease characterize by slow, progressive scarring of the space leading to dyspnea and stridor. Usually, initial treatment consists endoscopic procedures such as laser ablation dilation. However, only surgical leads long-term recurrence free survival.