A5082092007- Cancer, Lipids, and Metabolism
- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Diet, Metabolism, and Disease
- Phytoestrogen effects and research
- Retinoids in leukemia and cellular processes
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Regulation of Appetite and Obesity
- Prostate Cancer Treatment and Research
- Steroid Chemistry and Biochemistry
- Fatty Acid Research and Health
- Consumer Attitudes and Food Labeling
- Food composition and properties
- Gut microbiota and health
- Antiplatelet Therapy and Cardiovascular Diseases
- Advanced Glycation End Products research
- Platelet Disorders and Treatments
- Effects of Radiation Exposure
- Free Radicals and Antioxidants
- Exercise and Physiological Responses
Washington University in St. Louis
2023-2024
University of Illinois Urbana-Champaign
2016-2021
University of Missouri
2014-2017
East Carolina University
2015-2017
North Carolina Division of Public Health
2017
University of Virginia
2015-2017
Brown University
2015-2017
Rhode Island Hospital
2017
University of Cape Town
2015-2017
Wake Forest University
2015-2017
Cardiometabolic impairments that begin early in life are particularly critical, because they often predict metabolic dysfunction adulthood. Obesity, high-fat diet (HFD), and inactivity all associated with adipose tissue (AT) inflammation insulin resistance (IR), major predictors of dysfunction. Recent evidence has also the gut microbiome cardiometabolic health.
Previous studies of attenuated simian immunodeficiency virus (SIV) vaccines in rhesus macaques have demonstrated the development broad protection against experimental challenge, indicating potential for production highly effective immune responses to SIV antigens. However, this protective status was found be critically dependent on length time postvaccination with strain, suggesting a necessary maturation responses. In study, evolution envelope-specific antibodies monkeys experimentally...
To investigate the genetic contributors to cerebrovascular disease and variation in biomarkers of ischemic stroke. The Vitamin Intervention for Stroke Prevention Trial (VISP) was a randomized, controlled clinical trial B vitamin supplementation prevent recurrent stroke, myocardial infarction, or death. VISP collected baseline measures C-reactive protein (CRP), fibrinogen, creatinine, prothrombin fragments F1+2, thrombin-antithrombin complex, thrombomodulin prior treatment initiation....
Regular physical activity is effective in reducing visceral white adipose tissue (AT) inflammation and oxidative stress, these changes are commonly associated with reduced adiposity. However, the impact of multiple periods activity, intercalated by inactivity, i.e., intermittent on markers AT stress unknown. In present study, 5-wk-old male C57BL/6 mice were randomized into three groups (n = 10/group): sedentary, regular for 24 wk. All animals singly housed fed a diet containing 45% kcal from...
Exercise enhances insulin sensitivity; it also improves adipocyte metabolism and reduces adipose tissue inflammation through poorly defined mechanisms. Fibroblast growth factor 21 (FGF21) is a pleiotropic hormone-like protein whose insulin-sensitizing properties are predominantly mediated via receptor signaling in (AT). Recently, FGF21 has been demonstrated to have anti-inflammatory properties. Meanwhile, an association between exercise increased circulating levels reported some, but not all...
von Willebrand factor (vWF) plays an important role in thrombus formation during cerebrovascular damage. We sought to investigate the potential of circulating vWF recurrent events and identify genetic contributors variation level ischemic stroke population.We analyzed effect on risk using survival models VISP trial (Vitamin Intervention for Stroke Prevention) use reclassification over traditional factors. conducted a genome-wide association study) with imputation, based 1000 Genomes Project...
Diet and nutrition are undeniably two factors that have a major impact on the prevention, progression, treatment of various cancers. In this review, we will discuss how bioactives from diet nutritional status affect each hallmarks cancer. We present recent research using as means to prevent treat
The objective was to determine whether dietary tomato or lycopene supplementation impacted the expression of biomarkers associated with aggressive tumors and poorer prognostic outcomes in castration-resistant prostate cancer (CRPC). Transgenic adenocarcinoma mouse (TRAMP) mice were castrated at 12 weeks age mimic effects androgen deprivation therapy (ADT) leading CRPC. Mice separated into three groups (n = 30/group) fed powdered, modified AIN-93 G diets containing 10% powder (TP), beadlets...
The Receptor for Advanced Glycation End Products (RAGE) and its ligands have been shown to be both over expressed critical prostate cancer (PCa) development. Importantly, the overexpression of RAGE is associated with poor PCa patient survival, suggesting promise as a molecular target. Additionally, one largest sources RAGE, advanced glycation end products (AGEs), come from one's diet their concentrations are directly related disease. We hypothesized that dietary AGEs (dAGEs) significantly...
Background Prostate cancer (PCa) is the third most commonly diagnosed and sixth common cause of cancer‐related deaths in United States. Worldwide, PCa second fifth leading deaths. incidence higher more developed countries, with Australia/New Zealand North America having highest rates, while rates remain lowest Asian countries. The lower populations has been associated consumption soy foods. Soy under intensifying scrutiny recent years for its potential role prevention hormone‐driven cancers....
Epidemiological evidence continues to support the hypothesis that consumption of diets rich in tomato products are associated with a reduced risk prostate cancer, relationship supported by studies rodent models. Castration‐resistant cancer (CRPC) represents late and lethal phase human carcinogenesis, is defined as progression after surgical castration or pharmacologic reduction serum testosterone through androgen deprivation therapy (ADT). One mechanism involved transition CRPC cells’...
Tomatoes contain carotenoids that have the potential to alter effects of external beam radiation therapy (EBRT).We hypothesized dietary lyophilized tomato paste (TP) would reduce apoptosis within carotenoid-containing nonneoplastic tissues in EBRT-treated TRansgenic Adenocarcinoma Mouse Prostate (TRAMP) mice.Male TRAMP mice (n = 73) were provided an AIN-93G diet or a modified containing 10% TP (wt:wt) at 4 wk age. tumor growth was monitored by ultrasound. The caudal half mouse irradiated...
We have only begun to appreciate the negative metabolic impact of obesity development during adolescence. Whether mechanisms driving early changes are due obesity, poor dietary choices, or inactivity is not known. Obesity, high-fat diet (HFD), and all associated with adipose tissue (AT) inflammation insulin resistance (IR); here, unique these factors in progression disease a juvenile model was investigated. PURPOSE: To compare effects exercise (wheel running) HFD restriction on IR white...
Abstract Epidemiological data support the hypothesis that consumption of diets rich in tomato products are associated with a reduced risk prostate cancer. Castration-resistant cancer (CRPC) represents late and lethal phase human carcinogenesis, is defined as progression after surgical castration or pharmacologic reduction serum testosterone through androgen deprivation therapy. Mechanisms involved transition to CRPC include cells’ acquired capacity for synthesis activation ligand-independent...