A5102751227- Multiple Sclerosis Research Studies
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Vitamin D Research Studies
- Nuclear Receptors and Signaling
- Cerebral Venous Sinus Thrombosis
- Bone and Joint Diseases
- Transgenic Plants and Applications
- Glaucoma and retinal disorders
- Blood Coagulation and Thrombosis Mechanisms
- Metabolism and Genetic Disorders
- Balance, Gait, and Falls Prevention
- Immune Response and Inflammation
- Ultrasound and Hyperthermia Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Iron Metabolism and Disorders
- Transcranial Magnetic Stimulation Studies
- Autism Spectrum Disorder Research
- Platelet Disorders and Treatments
- Long-Term Effects of COVID-19
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
Cairo University
2014-2024
Cognitive impairment after stroke is common and can cause disability with major impacts on quality of life independence. Transcranial direct current stimulation may represent a promising tool for reconstitution cognitive functions in patients. This study aimed to investigate the effect transcranial Forty male patients were included. Patients divided randomly into two equal groups (A B). Group A received (tDCS) combination selected training program by RehaCom. B sham same program. evaluation...
Abstract Background Cognitive dysfunction is increasingly recognized in multiple sclerosis, even the early phase of disease. Multiple sclerosis patients with mild cognitive deficits may experience greater difficulties social contact and daily activities, irrespective physical handicap. This study aimed to estimate clinical predictors a sample Egyptian people MS. Results Significant worse performance assessed scales was observed MS as compared controls. related low educational level, long...
Hyperhomocysteinemia, vitamin B12 and folate deficiency have been linked to cognitive dysfunction in multiple sclerosis (MS) patients.This study aimed investigate the relation of serum homocysteine (Hcy), functions MS patients.Forty-five patients twenty matched healthy controls were included. Subjects submitted assessment using a selected psychometric battery measurement levels homocysteine, folic acid.MS showed significant worse performance scales compared (P ≤ 0.05). Serum no difference...
Abstract Background Inflammation is suggested to play a role in the development of non-motor Parkinson’s disease (PD) symptoms. We aimed investigate association between serum tumor necrosis factor-alpha (TNF-α) levels and cognition PD patients. Thirty patients with 30 healthy controls were included. Evaluation staging done using Unified Rating Scale. Cognitive assessment was Addenbrooke’s Examination (ACE-III) trail making B tests. Measurement TNF-α done. Results Patients had significantly...
Anecdotal reports have proposed that diet might influence the occurrence of seizures.Our objectives were to assess nutritional status in a sample patients with epilepsy and investigate impact nutrition on control.One hundred fifty participated study. To status, sociodemographic characteristics, anthropometric measurements, dietary food intake, 24-hour intake evaluated. Patients answered questions using frequency questionnaire.In epilepsy, there was insufficient water, fiber, potassium,...
Studies have just started delineating the role of Toll-like receptors (TLRs) in pathogenesis multiple sclerosis (MS).To investigate expression TLR-2 and TLR-4 on peripheral blood neutrophils lymphocytes Egyptian patients with MS, to examine as a candidate biomarker for MS diagnosis.A total 84 newly diagnosed 68 healthy controls were included this study. The levels assessed by flow cytometry technique using appropriate monoclonal antibodies.TLR-2 demonstrated significantly higher patients,...
Disturbance of balance and falls are commonly observed in people with multiple sclerosis (MS). The aim this study is to assess the postural patients MS by using clinical instrumental methods specify most direction instability among Biodex stability system (BSS). Fifty ambulatory individuals [42 relapsing-remitting (RRMS) 8 secondary progressive (SPMS)] were evaluated for quantitative Berg scale (BBS) BSS. Twenty healthy volunteers selected as a control group. There was statistically...
Abstract Background The changes in the different retinal layers Parkinson’s disease (PD) patients can be easily assessed using optical coherence tomography (OCT). Our aim was to evaluate structural with PD OCT. Structural measurements of nerve fiber layer (RNFL), macular and ganglion cell complex (GCC) thicknesses were obtained spectral domain tomography. Disease severity Unified Parkinson Rating Scale (UPDRS). Results Retinal parameters, except for superonasal inferonasal quadrants,...
Patients with sickle cell disease experience hemolytic anemia and vaso-occlusions that result in pain, organ injury, premature mortality. Several prospective studies have verified the efficacy tolerability of hydroxyurea (HU), demonstrated its reducing painful vaso-occlusive crises (VOCs) addition to ability increase Hb F levels. We aimed evaluate long-term effects HU therapy on assess long term safety patients. A retrospective study 60 patients was conducted. studied laboratory changes,...
Abstract The objective of this study was to evaluate children and adolescents with recurrent epistaxis spot variables that may predict underlying bleeding disorder. This a prospective study. Thirty-six were recruited from ENT outpatient clinic as well emergency room Cairo University hospital. Patients systemic causes for not included. All patients subjected basic workup differentiate between hematological epistaxis. Accordingly, extended investigations or coagulation studies performed....
Introduction Autistic spectrum disorders (ASDs) prevalence varies widely by sex and the racial/ethnic group. The male-to-female ratio ranged from 3 to 4 : 1. Some consider ASD be an autoimmune disorder, in which response developing brain myelin may impair anatomical development of neural pathways autistic children; this affects speed impulse transmission. Interleukin-12 (IL-12) is interleukin that naturally produced dendritic cells macrophages antigenic stimulation; it plays important role...
An association between antiepileptic drugs, low bone mineral density (BMD), fractures, and abnormalities in metabolism has been suggested for a longer period, although conclusive evidence not reported.Thirty epileptic patients 30 matched healthy subjects participated the study. Measurements of serum levels calcium, phosphorus, vitamin D, parathormone, alkaline phosphatase were done included subjects. Dual-energy X-ray absorptiometry (DEXA) scan was also performed.Serum D significantly lower,...
Abstract Background Development of novel biomarkers for multiple sclerosis (MS) is utmost importance to improve the capability predict disease progression and disability. Transcranial ultrasonography (TCS) a noninvasive imaging technique that allows visualization major parenchymal structures. This study aimed evaluate role transcranial sonography as predictor severity in MS patients. Sixty patients with clinically definite Multiple divided into two groups, relapsing–remitting (RRMS) group...
Background: A central role for apolipoprotein E (APOE) has been suggested in modulating processes of neurodegeneration. Objective: To study the association between serum APOE levels, gene polymorphisms, and Parkinson’s disease (PD). Material Methods: Fifty-five patients with PD 30 healthy subjects were enrolled. assessed using Unified Disease Rating Scale (UPDRS), Modified Hoehn Yahr scale, Schwab-England Activities Daily Living scale. Serum level genotyping polymorphisms done controls...
Abstract Background Transorbital sonography (TOS) has emerged as a promising assessment tool of the optic nerve and orbital arterial supply in multiple sclerosis (MS) patients. Objective To evaluate diameter (OND), sheath (ONSD), hemodynamics using TOS MS Methods Forty patients 28 matched healthy controls were included. Thirty-three eyes with previous neuritis (ON) 47 without ON examined. All subjects submitted to OND, ONSD, parameters ultrasound. Results OND ONSD smaller than controls. had...
Abstract Background Vitamin D is suggested to play an important role in neurodegenerative disorders. Objective T o examine the association between serum 25 vitamin D3 and Parkinson’s disease (PD). Materials methods Fifty patients suffering from PD fifty age- sex-matched healthy control subjects were included study. Patients subjected complete clinical assessment, Unified Parkinson Disease Rating Scale (UPDRS) was done evaluate severity of PD. Measurement using enzyme-linked immuno sorbent...
Although the pathogenesis of idiopathic intracranial hypertension (IIH) is still poorly understood, contribution inflammatory mechanisms has been proposed in its pathophysiology.This study aimed to measure serum tumor necrosis factor-α (TNF-α) levels patients with IIH and examine relationship clinical ophthalmological parameters cerebrospinal fluid (CSF) opening pressure.Thirty-six 30 healthy subjects were enrolled study. Patients subjected complete neurological, general, assessments. Serum...
Abstract Background Accumulating data have suggested that vitamin D receptor (VDR) gene is a pretender for vulnerability to Parkinson disease (PD). This study aimed assess the relationship of VDR polymorphisms (FokI and ApaI) with PD. Fifty patients suffering from PD 50 age- sex-matched healthy controls were included. Unified Disease Rating Scale (UPDRS) was done severity. Genetic testing single nucleotide using real time polymerase chain reaction (PCR) technique. Results Concerning...