A5004328721- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Cancer therapeutics and mechanisms
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Pneumonia and Respiratory Infections
- Histone Deacetylase Inhibitors Research
- Diet and metabolism studies
- Maternal and Neonatal Healthcare
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Cancer Treatment and Pharmacology
- Genomics and Chromatin Dynamics
- Protein Degradation and Inhibitors
- RNA Interference and Gene Delivery
- Lanthanide and Transition Metal Complexes
- DNA and Nucleic Acid Chemistry
- RNA modifications and cancer
- Metal complexes synthesis and properties
- Animal testing and alternatives
- Sepsis Diagnosis and Treatment
Haywards Heath Hospital
2011-2024
University of Glasgow
2007-2016
Cancer Research UK
2000-2012
Cancer Research UK Scotland Institute
2010-2012
University of Strathclyde
2010
University of the West of Scotland
2010
Institute of Cancer Research
2004-2007
London Cancer
2007
Hammersmith Hospital
1987-2007
Imperial College London
2007
The platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin are an important component of chemotherapy but limited by severe dose-limiting side effects the ability tumors to develop resistance rapidly. These can be improved through use drug-delivery vehicles that able target cancers passively or actively. In this study, we have tethered active drug a gold nanoparticle for delivery. Naked nanoparticles were functionalized with thiolated poly(ethylene glycol) (PEG) monolayer...
Abstract Purpose: To determine the safety, dose-limiting toxicity, maximum tolerated dose, and pharmacokinetic pharmacodynamic profiles of novel hydroxamate histone deacetylase inhibitor belinostat (previously named PXD101) in patients with advanced refractory solid tumors. Experimental Design: Sequential dose-escalating cohorts three to six received administered as a 30-min i.v. infusion on days 1 5 21-day cycle. Pharmacokinetic variables were evaluated at all dose levels. Pharmacodynamic...
The DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (decitabine) induces demethylation and re-expression of epigenetically silenced genes, increases carboplatin sensitivity tumor xenograft models. We designed a clinical study to determine the feasibility delivering dose decitabine, combined with carboplatin, that would be capable producing equivalent biologic effects in patients solid tumors.In two-stage design, 33 received escalating doses decitabine administered as 6-hour infusion...
Histone deacetylation and DNA methylation have a central role in the control of gene expression tumours, including transcriptional repression tumour suppressor genes involved sensitivity to chemotherapy. Treatment cisplatin-resistant cell lines with an inhibitor methyltransferases, 2-deoxy-5′azacytidine (decitabine), results partial reversal methylation, re-expression epigenetically silenced hMLH1 sensitisation cisplatin both vitro vivo. We investigated whether combination decitabine...
The clonogenic assay described in the Chapter 13 is not suitable for all cell lines. Many adherent lines do form colonies, and clearly it applicable to nonadherent Furthermore, slow time consuming. This chapter describes an alternative cytotoxicity that has a number of advantages when compared with assay. It quick easy allows large assays be carried out one batch. important consideration making comparisons between lines, cytotoxic agents, or evaluating combinations drugs. No ideal, always...
The incidence of melanoma is increasing rapidly, with advanced lesions generally failing to respond conventional chemotherapy. Here, we utilized DNA microarray-based gene expression profiling techniques identify molecular determinants progression within a unique panel isogenic human cell lines. When poorly tumorigenic line, derived from an early melanoma, was compared two increasingly aggressive derivative lines, the 66 genes significantly changed. A similar pattern differential found...
The cucurbit[n]uril (CB[n]) family of macrocycles has been shown to have potential in drug delivery where they are able provide physical and chemical stability drugs, improve solubility, control release mask the taste drugs. Cisplatin is a small molecule platinum-based anticancer that severe dose-limiting side-effects. forms host–guest complex with cucurbit[7]uril (cisplatin@CB[7]) platinum atom both chlorido ligands located inside macrocycle, binding stabilised by four hydrogen bonds...
Understanding the pathways that are targeted by cancer drugs is instrumental for their rational use in a clinical setting. Inhibitors of histone deacetylases (HDACI) selectively inhibit proliferation malignant cells and used treatment cancer, but selectivity understood poorly. We conducted functional genetic screen to address mechanism(s) action HDACI. report here ectopic expression two genes act on retinoic acid (RA) signaling can cause resistance growth arrest apoptosis induced HDACI...
<h3>Objectives</h3> To explore factors influencing the likelihood of antenatal vaccine acceptance both routine UK vaccines (influenza and pertussis) a hypothetical group B <i>Streptococcus</i> (GBS) in order to improve understanding how optimise immunisation acceptance, use clinical trials. <h3>Setting</h3> An online survey distributed women childbearing age UK. <h3>Participants</h3> 1013 aged 18–44 years England, Scotland Wales. <h3>Methods</h3> Data from an conducted gauge attitudes Wales...
// Natividad Gomez-Roman 1 , Neha Mohan Sahasrabudhe 2 Fiona McGregor Anthony J. Chalmers Jim Cassidy 1, 3 Jane Plumb Wolfson Wohl Translational Cancer Research Centre, Institute of Sciences, University Glasgow, UK The Medical Center in Groningen, Netherlands Current address: VP Oncology at Bristol Myers Squibb, Princeton, New Jersey, USA Correspondence to: Gomez-Roman, e-mail: Maria.Gomez-Roman@glasgow.ac.uk Keywords: Rab25, HIF-1 alpha, tumourigenic, ovarian cancer, intraperitoneal...
A new class of cytotoxic heteroaromatic cations is presented, based on the dihydro-imidazo-phenanthridinium framework (DIP), that have affinity for DNA and cytotoxicity toward cancerous cells. The DIP particularly tunable due to flexible synthetic methodology. Furthermore, central moiety has proved be very stable hydrolysis reduction compared other phenanthridinium-based agents.