A5066584437- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Innovative Microfluidic and Catalytic Techniques Innovation
- Ultrasound and Cavitation Phenomena
- Vanadium and Halogenation Chemistry
- Advanced Photocatalysis Techniques
- Nanomaterials for catalytic reactions
- Polyoxometalates: Synthesis and Applications
- Radioactive element chemistry and processing
- Catalytic Processes in Materials Science
University of Manchester
2020-2022
Eindhoven University of Technology
2018-2020
KU Leuven
2017
A mild and selective C(sp
Sulfonamides are key motifs in pharmaceuticals and agrochemicals, spurring the continuous development of novel efficient synthetic methods to access these functional groups. Herein, we report an environmentally benign electrochemical method which enables oxidative coupling between thiols amines, two readily available inexpensive commodity chemicals. The transformation is completely driven by electricity, does not require any sacrificial reagent or additional catalysts can be carried out only...
Abstract C–H functionalization chemistry is one of the most vibrant research areas within synthetic organic chemistry. While researchers focus on development small-scale batch-type transformations, more recently such transformations have been carried out in flow reactors to explore new chemical space, boost reactivity or enable scalability this important reaction class. Herein, an up-to-date overview bond reactions continuous-flow microreactors presented. A comprehensive which establish...
Abstract Vicinal diamines are ubiquitous materials in organic and medicinal chemistry. The direct coupling of olefins amines would be an ideal approach to construct these motifs. However, alkene diamination remains a long‐standing challenge synthesis, especially when using two different amine components. We report general strategy for the selective assembly vicinal 1,2‐diamines readily available olefin building blocks. This mild straightforward involves situ formation photoinduced activation...
Abstract A mild and selective C(sp 3 )−H aerobic oxidation enabled by decatungstate photocatalysis has been developed. The reaction can be significantly improved in a microflow reactor enabling the safe use of oxygen enhanced irradiation mixture. Our method allows for both activated unactivated C−H bonds (30 examples). ability to selectively oxidize natural scaffolds, such as (−)‐ambroxide, pregnenolone acetate, (+)‐sclareolide, artemisinin, exemplifies utility this new method.
Indoles are among the most important N-heterocycles in pharmaceuticals. Here, we present an alternative to classic Fischer indole synthesis based on radical coupling between aryl diazoniums and alkyl iodides. This iron-mediated strategy features a double role for that sequentially activate iodides through halogen-atom transfer then serve as acceptors. The process operates under mild conditions enables preparation of densely functionalized indoles.
Abstract Vicinal diamines are ubiquitous materials in organic and medicinal chemistry. The direct coupling of olefins amines would be an ideal approach to construct these motifs. However, alkene diamination remains a long‐standing challenge synthesis, especially when using two different amine components. We report general strategy for the selective assembly vicinal 1,2‐diamines readily available olefin building blocks. This mild straightforward involves situ formation photoinduced activation...
Abstract Here we report a desaturative approach for oxindole synthesis. This method uses simple ethyl 2-(2-oxocyclohexyl)acetates and primary amine building blocks as coupling partners. A dual photoredox–cobalt manifold is used to generate secondary aniline that, upon heating, cyclizes with the pendent ester functionality. The process operates under mild conditions was applied modification of several amino acids, blockbuster drug mexiletine, well formation dihydroquinolinones.