A5062055936- Virus-based gene therapy research
- Human-Automation Interaction and Safety
- RNA modifications and cancer
- Sarcoma Diagnosis and Treatment
- Occupational Health and Safety Research
- Bone Tumor Diagnosis and Treatments
- Polymer Nanocomposites and Properties
- Technostress in Professional Settings
- Polymer crystallization and properties
- Rheology and Fluid Dynamics Studies
Dartmouth College
2025
Children's Hospital at Montefiore
2017
Albert Einstein College of Medicine
2017
Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Although histologically defined by presence of osteoid, possesses lineage multipotency suggesting it could be derived from a cell anywhere on differentiation pathway between mesenchymal stem (MSC) mature osteoblast. To determine if preosteoblasts (pOB) origin differentiated MSCs were transformed with genetic elements. pOB same serially oncogenes hTERT, SV40 large T antigen H-Ras. Assays performed to...
Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor in children and young adults. It remains unclear at what point pathway of differentiation between human mesenchymal stem cells (hMSCs) osteoblasts (OBs), OS originates. Since high grade frequently demonstrates histologic variability, as well potential for multi-lineage differentiation, some consider hMSC cell origin OS, whereas others believe osteoblast to be likely origin. Identifying crucial understanding molecular...