A5011506890- Systemic Lupus Erythematosus Research
- Multiple Sclerosis Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Advanced Neuroimaging Techniques and Applications
- RNA regulation and disease
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Neurological disorders and treatments
- Protein Tyrosine Phosphatases
- Mind wandering and attention
- Early Childhood Education and Development
- Parkinson's Disease Mechanisms and Treatments
- Diabetes and associated disorders
- Advanced MRI Techniques and Applications
- Cognitive Abilities and Testing
- Gambling Behavior and Treatments
- Lipid metabolism and disorders
- Grit, Self-Efficacy, and Motivation
- Vestibular and auditory disorders
- Bone and Joint Diseases
Lund University
2019-2024
Scania (Sweden)
2024
Skåne University Hospital
2023
Kepler Universitätsklinikum
2018
Abstract Coming from a disadvantaged background can have negative impact on an individual’s educational trajectory. Some people however seem unaffected and cope well with the demands challenges posed by school education, despite growing up in adverse conditions, phenomenon termed academic resilience . While it is uncertain which underlying factors make some more likely to circumvent unfavorable odds than others, both socioeconomic status (SES) cognitive ability robustly been linked...
Dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) has previously shown alterations in cerebral perfusion patients with systemic lupus erythematosus (SLE). However, the results have been inconsistent, particular regarding neuropsychiatric (NP) SLE. Thus, we investigated perfusion-based measures different brain regions SLE and without NP involvement, additionally, white matter hyperintensities (WMHs), most common MRI pathology patients.We included 3 T images (conventional...
Background The differential diagnosis of progressive supranuclear palsy (PSP) and Lewy body disorders, which include Parkinson disease dementia with bodies, is often challenging due to the overlapping symptoms. Purpose To develop a diagnostic tool based on diffusion tensor imaging (DTI) distinguish between PSP disorders at individual-subject level. Materials Methods In this retrospective study, skeletonized DTI metrics were extracted from two independent data sets: discovery cohort Swedish...
Previous research has provided evidence for cognitive dysfunction as a common symptom of systemic lupus erythematosus (SLE). In light this, the primary goal this study was to investigate how impairment in patient group develops over time. addition, present dataset contributes delineating specific abilities that are impaired SLE patients well answering question whether disease affects cognition with neuropsychiatric manifestations (NPSLE) and without (non-NPSLE) distinct ways.91 female...
Introduction Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease affecting multiple organs in the human body, including central nervous system. Recently, artificial intelligence method called BrainAGE (Brain Age Gap Estimation), defined as predicted age minus chronological age, has been developed to measure deviation of brain aging from a healthy population using MRI. Our aim was evaluate SLE patients deep-learning model. Methods Seventy female with clinical...
There are many ways to acquire and process diffusion MRI (dMRI) data for group studies, but it is unknown which maximizes the sensitivity white matter (WM) pathology. Inspired by this question, we analyzed acquired tensor imaging (DTI) kurtosis (DKI) at 3T (3T-DTI 3T-DKI) DTI 7T in patients with systemic lupus erythematosus (SLE) healthy controls (HC). Parameter estimates 72 WM tracts were obtained using TractSeg. The impact on pathology was evaluated protocol, magnetic field strength,...
Abstract Currently, little is known about the spatial distribution of white matter hyperintensities (WMH) in brain patients with Systemic Lupus erythematosus (SLE). Previous lesion markers, such as number and volume, ignore strategic location WMH. The goal this work was to develop a fully-automated method identify predominant patterns WMH across WM tracts based on cluster analysis. A total 221 SLE without neuropsychiatric symptoms from two different sites were included study. segmentations...
The purpose of this study is to investigate possible differences in brain structure, as measured by T1-weighted MRI, between patients with systemic lupus erythematosus (SLE) and healthy controls (HC), whether any observed were turn more severe SLE neuropsychiatric manifestations (NPSLE) than those without (non-NPSLE). Structural MRI was performed on 69 female (mean age = 35.8 years, range 18-51 years) 24 age-matched HC 36.8 23-52 conjunction neuropsychological assessment using the CNS Vital...
Motivation: Cognitive dysfunction (CD), fatigue and pain are common debilitating in systemic lupus erythematosus (SLE). Symptom-based neuroimaging could contribute to pathophysiological models patient-centered care. Goal(s): Investigating brain perfusion blood-brain barrier permeability SLE patients with CD, pain. Approach: 66 underwent 3T dynamic susceptibility contrast (DSC) MRI. The leakage parameter K2 normalized corrected parameters were estimated 14 regions, compared by symptomatology....
Childhood is a period of extensive cortical and neural development. Among other things, axons in the brain gradually become more myelinated, promoting propagation electrical signals between different parts brain, which turn may facilitate skill Myelin difficult to assess vivo, measurement techniques are only just beginning make their way into standard imaging protocols human cognitive neuroscience. An approach that has been proposed as an indirect measure myelin T1w/T2w ratio, contrast based...
ABSTRACT Currently, little is known about the spatial distribution of white matter hyperintensities (WMH) in brain patients with Systemic Lupus erythematosus (SLE). Previous lesion markers, such as number and volume, ignore strategic location WMH. The goal this work was to develop a fully-automated method identify predominant patterns WMH across WM tracts based on cluster analysis. A total 221 SLE without neuropsychiatric symptoms from two different sites were included study. segmentations...