A5001870414- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Orthopaedic implants and arthroplasty
- Medical Imaging and Analysis
- Vascular Malformations Diagnosis and Treatment
- Neurosurgical Procedures and Complications
- Shoulder Injury and Treatment
- Spinal Hematomas and Complications
- Intracranial Aneurysms: Treatment and Complications
- Glioma Diagnosis and Treatment
- Musculoskeletal pain and rehabilitation
- Moyamoya disease diagnosis and treatment
- Pain Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Brain Metastases and Treatment
- Cervical and Thoracic Myelopathy
- Meningioma and schwannoma management
- Bone and Dental Protein Studies
- Acute Ischemic Stroke Management
- Trauma Management and Diagnosis
- Pituitary Gland Disorders and Treatments
- Aortic aneurysm repair treatments
- Advanced Electron Microscopy Techniques and Applications
University of Florida
2024-2025
Lahey Medical Center
2024-2025
Lahey Hospital and Medical Center
2023-2025
Queen's University
2024
Cedars-Sinai Medical Center
2018-2023
Cedars-Sinai Smidt Heart Institute
2022
The Core Institute
2021
Phoenix (United States)
2021
Neurological Surgery
2020
Mount Sinai Hospital
2020
Low back pain (LBP) is often associated with the degeneration of human intervertebral discs (IVDs). However, pain-inducing mechanism in degenerating remains to be elucidated. Here, we identified a subtype locally residing nucleus pulposus cells (NPCs), generated by certain conditions discs, that was onset discogenic pain. Single-cell transcriptomic analysis tissues showed strong correlation between specific cell and condition degenerated disc, suggesting they are pain-triggering. The...
Children experiencing severe neurological deficit due to acute ischemic stroke may benefit from endovascular intervention. The authors describe the use of mechanical thrombectomy in treatment embolic occlusion secondary an atrial myxoma a pediatric patient. This case involved 11-year-old boy with history notable for Raynaud syndrome and distal extremity rash who presented emergency department dense hemiparesis thromboembolic M1 segment middle cerebral artery. Following thrombectomy,...
Background/Objectives: Spinal fusion surgery is an accepted form of management for select patients who suffer from degenerative lumbar disease. The need cost-effective durable techniques paramount as our population ages. This study compares the radiographic and clinical outcomes PEEK 3D-printed titanium interbody cages. Methods: compared two cohorts which underwent either or (3DPT) at a single institution between 2013 2022. cohort was retrospective analysis prospectively collected registry....
Over the past two decades, many investigators have reported how extracellular matrix molecules act to regulate neuroplasticity. The majority of these studies involve proteins which are targets metalloproteinases. Importantly, enzyme/substrate interactions can degenerative and regenerative phases synaptic plasticity, directing axonal dendritic reorganization after brain insult. present review first summarizes literature support for prominent role metalloproteinases during neuroregeneration,...
BACKGROUND: Robotic systems are gaining acceptance as a preferred tool for the placement of electrodes stereotactic electroencephalography (SEEG) studies. OBJECTIVE: To describe technical methods insertion SEEG using Medtronic Stealth Autoguide robotic system and detailed outcomes in initial 9 patients implanted. METHODS: Nine underwent studies with use system. Patients had at least 10 placed. Targets were planned on S8 planning station, placed under general anesthesia. A technique is...
Abstract Objective To identify perioperative factors that may predict postoperative cerebrospinal fluid (CSF) leak and meningitis following expanded endoscopic transsphenoidal surgery (EETS). Study Design This is a retrospective study. study was set at the Cedars-Sinai Medical Center, Los Angeles. A total of 78 patients who underwent EETS between January 2007 November 2018 were participated. The main outcome measures CSF meningitis. Results 100 procedures; 17.9 10.3% developed leaks...
Tendons and ligaments have a poor innate healing capacity, yet account for 50% of musculoskeletal injuries in the United States. Full structure function restoration postinjury remains an unmet clinical need. This study aimed to assess application novel three dimensional (3D) printed scaffolds induced pluripotent stem cell-derived mesenchymal cells (iMSCs) overexpressing transcription factor Scleraxis (SCX, iMSC
Abstract The role of cervicomedullary decompression (CMD) in the care hydrocephalic achondroplastic children who present with simultaneous foramen magnum stenosis is not well understood. We sought to determine percentage symptomatic had stabilization or improvement ventriculomegaly following CMD. authors retrospectively reviewed records pediatric patients at Cedars‐Sinai Medical Center achondroplasia and signs progressive underwent CMD for between years 2000 2018. Clinical outcomes included...
Lateral lumbar interbody fusion (LLIF) is an advantageous approach for spinal arthrodesis a wide range of disorders including degenerative, genetic, and traumatic conditions. LLIF techniques have evolved over the past 15 years regarding surgical approach, with concomitant improvements in implant material design. Bioactive materials been focus development novel methods, which reduce risk subsidence pseudarthrosis. Historically, polyetheretherketone titanium cages selected their biomechanical...
Study Design Retrospective cohort study Objectives To describe the common types of complications and their risk factors during spine surgery in patients with achondroplasia. Methods A retrospective review was performed medical records adult achondroplasia who underwent at our institution between 2007 2021. Inclusion criteria were age >16 years. Surgical encounters evaluated for durotomy, postoperative neurologic deficit, wound compromise, complications, return to operating room....
Osteoid osteoma is a benign primary bone tumor of unknown etiology that occurs most commonly in males during adolescence and early adulthood. affects the spine 20% cases, may cause spinal deformity, stiffness, pain sometimes be worst at night. We present novel description partial laminectomy with cement augmentation after resection an osteoid osteoma. A 22-year-old male past medical history Hodgkin's lymphoma status post chemotherapy radiation to mediastinum, right hip osteoblastoma treated...
Encephaloduroarteriosynangiosis (EDAS) is a form of indirect revascularization for cerebral arterial steno-occlusive disorders. EDAS has gained growing interest as technique applicable to pediatric and adult populations several types ischemic conditions.To present team-oriented, multidisciplinary update the application in challenging cases cerebrovascular stenosis/occlusion, successfully implemented more than 200 cases.We describe demonstrate step-by-step multidisciplinary-modified...
Background Adhesive capsulitis is a common cause of glenohumeral joint pain and stiffness that significantly interferes with patients' lives ability to work. Since no specific treatment options have been well established, this research examines arthrographic injection the steroid local anesthetic versus alone for adhesive capsulitis. Methods A double-blinded randomized controlled trial was conducted patients diagnosed idiopathic They were one two groups: (1)local plus or (2)local anesthetic....
Sarathy, Danyas MD; Lucke-Wold, Brandon MD, PhD; Chan, Julie L. PhD Author Information
Abstract Low back pain (LBP) is often associated with the degeneration of human intervertebral discs (IVDs). However, pain-inducing mechanism in degenerating remains to be elucidated. Here, we identified a subtype locally residing nucleus pulposus cells (NPCs), generated by environmental stress discs, that triggered onset discogenic LBP. Single-cell transcriptomic analysis tissues showed strong correlation between this specific pain-triggering and conditions degenerated discs. Next,...
Meningiomas are the most common primary intracranial tumor with increasing incidence. Stereotactic Radiosurgery Gamma Knife (SRS-GK) is a commonly used modality for neoadjuvant and adjuvant treatment of these tumors often necessary long-term disease control, particularly World Health Organization grade II/III meningiomas. While there strong evidence to support use SRS-GK meningioma, exists risk secondary malignancy that not well understood. We report case glioblastoma (GBM) arose near bed...
Department of Neurosurgery, Lahey Hospital and Medical Center, Burlington, Massachusetts, USA Correspondence: Robert G. Whitmore, MD, 41 Mall Rd, MA01805, USA. Email: [email protected]