A5050649410- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Vestibular and auditory disorders
- Multiple Myeloma Research and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Ocular Infections and Treatments
- Retinal Imaging and Analysis
- Protein Degradation and Inhibitors
- Intraocular Surgery and Lenses
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Assistive Technology in Communication and Mobility
- Genetic Associations and Epidemiology
- Statistical Methods in Clinical Trials
- Hearing, Cochlea, Tinnitus, Genetics
- Meta-analysis and systematic reviews
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hemodynamic Monitoring and Therapy
- Ophthalmology and Visual Health Research
Moorfields Eye Hospital NHS Foundation Trust
2015-2020
University College London
2015-2020
Moorfields Eye Hospital
2015-2018
National Institute for Health Research
2017-2018
NIHR Biomedical Research Centre at The Royal Marsden and the ICR
2018
Institute of Ophthalmology
2018
UCL Biomedical Research Centre
2017
NIHR Moorfields Biomedical Research Centre
2015
University of Leeds
2014
Cancer Research UK
2014
At the molecular level, myeloma is characterized by copy number abnormalities and recurrent translocations into immunoglobulin heavy chain locus. Novel methods, such as massively parallel sequencing, have begun to describe pattern of tumor-acquired mutations, but their clinical relevance has yet be established.We performed whole-exome sequencing for 463 patients who presented with were enrolled onto National Cancer Research Institute Myeloma XI trial, whom complete cytogenetic outcome data...
PurposeTo compare Schlemm canal (SC) and trabecular meshwork (TM) in children with healthy eyes those without glaucoma after lensectomy.DesignCross-sectional observational study.ParticipantsFifty 4 to 16 years of age 48 who underwent lensectomy (124 72 postlensectomy eyes).MethodsAnterior segment (AS) OCT (Tomey SS-1000 CASIA; Tomey, Nagoya, Japan) the nasal iridocorneal angle at 2 levels accommodative effort (2.5 diopters [D] 15 D). For each parameter state accommodation, a random effects...
<h3>Purpose</h3> To determine risk factors for the development of acute corneal hydrops in keratoconus UK a case-controlled study. <h3>Methods</h3> Between November 2009 and December 2010, we prospectively identified 73 individuals who developed hydrops. We then 174 controls from nine regions with had not For cases recorded demographics clinical features. Univariate multivariable logistic regressions were performed to identify factors. <h3>Results</h3> analysis suggested strong associations...
Background Carbonic anhydrase inhibitors (CAIs) are frequently used as an initial step to treat retinitis pigmentosa-associated cystoid macular oedema (RP-CMO). Interestingly, it has been postulated that CAIs might reduce outer nuclear layer (ONL) fluid more effectively than inner (INL) due better access retinal pigment epithelium basolateral membrane neurosensory retina. This retrospective cohort study explores if association between spatial distribution of spaces in RP-CMO and CAI response...
The purpose of this study was to explore changes in Schlemm canal (SC), trabecular meshwork (TM), and iridocorneal angle (ICA) morphology during accommodative effort children young adults.We acquired anterior segment optical coherence tomography images (AS-OCT) the ICA ciliary muscle (CM) both eyes 50 age 4 16 years with healthy eyes, at two levels accommodation: 2.5 15 diopters (D). Semiautomated nasal measurements were as follows: opening distance 500/750 μm (AOD-500, -750), iris space...
Purpose: We determined whether there is relative sparing of pupil function in glaucoma patients with normal pressures compared to those high pressures. Methods: A cross-sectional study was done 68 primary open angle (POAG): 38 had IOPs on all-day phasing before treatment (never >21 mm Hg), confirmed progression glaucomatous optic neuropathy (NTG) and 30 associated elevated intraocular (>25 Hg; HP-POAG). The afferent pupillary defect (RAPD) quantified the RAPDx device, mean deviation visual...
The optimal management of infantile nystagmus syndrome (INS) is still unclear. Contact lenses (CL) may be superior to glasses in improving visual function INS but it not known whether their beneficial effects are due optical correction alone, or an additional proprioceptive effect, and soft CLs would as effective rigid CLs. There little data on feasibility the present study aimed provide this information.We completed a pilot Randomized Control Trial (RCT) at single tertiary referral centre...
Introduction Low vision and blindness adversely affect education independence of children young people. New ‘assistive’ technologies such as tablet computers can display text in enlarged font, read out to the user, allow speech input conversion into typed text, offer document spreadsheet processing give access wide sources information internet. Research on these devices low has been limited case series. Methods analysis We will carry a pilot randomised controlled trial (RCT) assess...
To establish the efficacy and safety of bimatoprost 0.03% monotherapy in glaucoma ocular hypertension (OHT) patients with inadequate intraocular pressure (IOP)on current therapy.Pre- post-switch IOPs were analyzed for 59 consecutive who switched from therapy to between 2011-2015. Demographic information, diagnosis, any adverse events recorded. Change IOP post-pre switch was using a 2-sided Student's paired t-test at 5% significance level.There statistically significant mean reduction first...
IINS is associated with mild/moderate visual impairment, strabismus and compensatory head postures (CHP), which can negatively impact quality of life. Standard acuity assessments tend to underestimate the effect on functioning. Published evidence INS life slowly emerging. Our study examines functioning adults using National Eye Institute Visual Function Questionairre-25 (VFQ-25).38 participants were recruited participate in study. All underwent detailed clinical examination, as well...