A5034237358- Dietetics, Nutrition, and Education
- DNA Repair Mechanisms
- Fungal and yeast genetics research
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Research in Social Sciences
- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Higher Education and Employability
- Photosynthetic Processes and Mechanisms
- Higher Education Learning Practices
- PARP inhibition in cancer therapy
- Microtubule and mitosis dynamics
- Genetics and Neurodevelopmental Disorders
- RNA Research and Splicing
- Chromosomal and Genetic Variations
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
Atlantic Technological University
2024
Technological University Dublin
2024
University of California, Davis
2018-2021
Howard Hughes Medical Institute
2018-2021
City of Hope
2020
Beckman Research Institute
2020
Occidental College
2013
Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully produce haploid gametes. To date, only a handful meiotic targets have been identified. Here, we delineate multidimensional SUMO-modified proteome in budding yeast, identifying 2747 conjugation sites 775 targets, and defining their relative levels dynamics. Modified cluster disordered regions minority match consensus motifs. Target identities dynamics imply that SUMOylation regulates all chromosome...
RAD52 is a structurally and functionally conserved component of the DNA double-strand break (DSB) repair apparatus from budding yeast to humans. We recently showed that expressing human gene, HsRAD52 in rad52 mutant cells can suppress both their ionizing radiation (IR) sensitivity homologous recombination (HRR) defects. Intriguingly, we observed supports DSB by mechanism HRR conserves genome structure independent canonical HR machinery. In this study report naturally occurring variants...
Abstract Background In Saccharomyces cerevisiae , Rad59 is required for multiple homologous recombination mechanisms and viability in DNA replication-defective rad27 mutant cells. Recently, four rad59 missense alleles were found to have distinct effects on that are consistent with separation-of-function mutations. The rad59-K166A allele alters an amino acid a conserved α-helical domain, and, like the null diminishes association of Rad52 double-strand breaks. rad59-K174A rad59-F180A alter...
Abstract Background Undergraduate nutrition programmes prepare students and graduates for a wide range of employment opportunities. However, little is known about how employers perceive current education practices in Ireland well are prepared the realities today's workforce. The present study aimed to explore employers' perspectives placement graduates' competencies Methods Interviews were conducted with 12 across UK who currently or have recently employed Irish supervised students....
Protein modification by SUMO helps orchestrate the elaborate events of meiosis to faithfully produce haploid gametes. To date, only a handful meiotic targets have been identified. Here we delineate multidimensional SUMO-modified proteome in budding yeast, identifying 2747 conjugation sites 775 targets, and defining their relative levels dynamics. Modified cluster disordered regions minority match consensus motifs. Target identities dynamics imply that SUMOylation regulates all chromosome...
Abstract During meiosis, crossover recombination connects homologous chromosomes to direct their accurate segregation 1 . Defects in crossing over cause infertility, miscarriage and congenital disease. Accordingly, each pair of attains at least one through processes that designate then implement with high efficiency 2 At the DNA level, is implemented formation biased resolution double-Holliday Junction intermediates 3–5 A central tenet two Holliday junctions are resolved opposite planes by...