A5060874401- Bone and Joint Diseases
- Colorectal Cancer Treatments and Studies
- Bone health and treatments
- Genetic factors in colorectal cancer
- Hip disorders and treatments
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Natural Compounds in Disease Treatment
- Natural product bioactivities and synthesis
- Rheumatoid Arthritis Research and Therapies
- NF-κB Signaling Pathways
- Helicobacter pylori-related gastroenterology studies
- Angiogenesis and VEGF in Cancer
- Immune Response and Inflammation
- Synthesis and biological activity
- Biochemical and Molecular Research
- Medicinal Plant Pharmacodynamics Research
- Signaling Pathways in Disease
- Ferroptosis and cancer prognosis
- Cell death mechanisms and regulation
- Traditional Chinese Medicine Studies
- Bioactive natural compounds
- Cancer Treatment and Pharmacology
- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
Guangdong Provincial People's Hospital
2021-2024
Guangdong Academy of Medical Sciences
2009-2024
Southern Medical University
2024
Inner Mongolia Medical University
2008-2024
Mongolian National University of Medical Sciences
2020
Guangdong General Hospital
2009-2017
Sun Yat-sen University Cancer Center
2007-2009
Sun Yat-sen University
2007-2009
Abstract To investigate the efficacy and mechanisms of matrine, a component derived from Sophora flavescens in treatment rheumatoid arthritis (RA), rat model RA was established. Compared to control rats, matrine significantly mitigated inflammation severity (paw volume articular index (AI) score). Using either mice splenic T cells stimulated with PMA/ionomycin or cells, levels Th1 Th2 responses were determined by flow cytometry, quantitative RT‐PCR, ELISA. Furthermore, NF‐κBp65 (RelA), IκBα,...
The induction of apoptosis-resistant rheumatoid synovial tissue cells has been related to constitutively active Janus kinase/signal transducers and activators transcription (JAK/STAT) signaling in arthritis (RA). excessive proliferation inherent resistance apoptosis fibroblast-like synoviocytes (FLS) is an important mechanism by which RA originates. However, the effects matrine on FLS unclear. present study aimed investigate action a rat model collagen‑induced (CIA). CIA was established...
Gastric cancer is one of the most commonly diagnosed malignancies, and a majority patients with gastric are at an advanced stage. However, association between metastatic patterns survival outcomes in has not been fully explored. In present study, we aimed to investigate their prognosis cancer.
Steroid-induced osteonecrosis of the femoral head (ONFH) is a disease bone. Metabolism and genetic factors are generally considered to play an important role. The purpose this study was investigate relationship between single-nucleotide polymorphisms (SNPs) in MIR17HG MIR155HG risk steroid-induced ONFH population northern China.A total 199 patients 506 healthy controls were recruited for study. Four SNPs seven genotyped by Sequenom MassARRAY. ORs 95% CIs used evaluate these ONFH.In...
e18043 Background: Despite multimodality standard therapy, patients with locally advanced head and neck squamous cell carcinoma are at high risk of recurrence distant metastasis. The safety efficacy immunotherapy (pembrolizumab) has been reported in recurrent/metastatic HNSCC. We hypothesized that neoadjuvant chemo-immunotherapy a positive effect on decreasing metastasis, preserving organ function extending survival time. Methods: In this prospective, non-randomized, single-arm phase II...
The proto-oncogene c-MET (mesenchymal-epithelial transition factor gene) plays a critical role in cellular proliferation, survival, migration, and invasion cancers. aim of this study is to explore the relationship between expression clinicopathological characteristics colorectal cancer (CRC) patients.A total 337 enrolled patients were collected present study. Here, EGFR detected by immunohistochemistry (IHC). mutational statuses KRAS exons 2, 3, 4, NRAS BRAF exon 15 from formalin-fixed...
Abstract Background : Steroid-induced osteonecrosis of the femoral head (ONFH) is aseptic necrosis caused by glucocorticoid use. Once necrotic occurs, it irreversibly affects quality life seriously. Studies have shown that susceptibility to steroid-induced ONFH likely be related variation miRNA coding genes. Therefore, this study aimed was investigate effect MIR3142HG on ONFH. Methods Agena MassARRAY used genotype gene rs1582417, rs2431689, rs7727155 and rs17057846 in 199 patients 506...
<b><i>Background:</i></b> Steroid-induced osteonecrosis of the femoral head (ONFH) is aseptic necrosis caused by glucocorticoid use. Once necrotic occurs, it irreversibly affects quality life seriously. Studies have shown that susceptibility to steroid-induced ONFH likely be related variation miRNA-coding genes. Therefore, this study aimed was investigate effect <i>MIR3142HG</i> on ONFH. <b><i>Methods:</i></b> Agena MassARRAY used...
// Xin Li 1 , Shijiang Xing and Qiumei Dong 2 Department of Medical Oncology, Xiaolan People's Hospital Affiliated to Southern University, Zhongshan, China Guangdong General & Academy Sciences, Guangzhou, Correspondence to: Dong, email: hrbsh@163.com Keywords: Down syndrome, non-small-cell lung cancer, EGFR mutation, trisomy 21, EGFR-TKIs resistance Received: February 07, 2017     Accepted: April 03, Published: 25, 2017 ABSTRACT Background : Solid tumors have a...
Abstract IntroductionSteroid-induced osteonecrosis of the femoral head (ONFH ) is a disease bone metabolism, and genetic factors are generally considered to play an important role. The purpose this study was investigate relationship between single nucleotide polymorphisms (SNPs) in MIR17HG MIR155HG risk steroid-induced ONFH population northern China.MethodsA total 199 patients 506 healthy controls were recruited for study. Four SNPs seven genotyped by Sequenom MassARRAY. ORs 95% CIs used...