A5100423083- Bone and Joint Diseases
- Bone health and treatments
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Chronic Disease Management Strategies
- Health disparities and outcomes
- Healthcare Systems and Reforms
- Monoclonal and Polyclonal Antibodies Research
- Peroxisome Proliferator-Activated Receptors
- Mental Health Treatment and Access
- Tribology and Wear Analysis
- Ophthalmology and Visual Health Research
- Career Development and Diversity
- Biological and pharmacological studies of plants
- Ergonomics and Musculoskeletal Disorders
- Pharmacological Effects and Assays
- Hydraulic and Pneumatic Systems
- Influenza Virus Research Studies
- Sports Performance and Training
- Neurobiology and Insect Physiology Research
- Silk-based biomaterials and applications
- Ferroptosis and cancer prognosis
- Doctoral Education Challenges and Solutions
- Immunotherapy and Immune Responses
- Interdisciplinary Research and Collaboration
Huazhong University of Science and Technology
2024-2025
Tongji Hospital
2024-2025
Wuhan University
2025
Nanjing Medical University
2024
Ministry of Education of the People's Republic of China
2024
Hubei University of Technology
2024
Northwestern Polytechnical University
2023-2024
The University of Texas at San Antonio
2024
University of Alberta
2024
Drexel University
2024
Abstract Background Multimorbidity has become one of the main challenges in health care system. The association between prevalence, patterns multimorbidity and utilization is less often discussed China. purpose this study to examine among Chinese middle-aged older adults take into account different sociodemographic, behavioral characteristics. Based on this, implications current evidence effective intervention can be identified put practice. Methods wave 4 2018 China Health Retirement...
ABCC1 belongs to the ATP-binding cassette (ABC) superfamily, which encompasses a total of 48 constituent members. has been shown be associated with growth, progression, and drug resistance various types cancer. However, impact on cancer immune infiltration pan-cancer prognosis rarely studied. Our comprehensive analysis unveiled elevated expression across cancers. overexpression consistently predicted unfavorable outcomes based TCGA data. Moreover, exhibited intricate associations diverse...
Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and abnormal MET expression plays crucial role in its progression. However, the specific pathogenic mechanisms of HCC have yet to be fully elucidated. This study aimed uncover oncogenic explore potential therapeutic implications. Transcriptomic data from HTVi MET/β-catenin model GSEA results TCGA LIHC cohorts were analyzed identify key genes development. In vitro assays vivo models used investigate TRIB3 Immunofluorescence...
1-17-2 is a rat anti-human DEC-205 monoclonal antibody that induces internalization and delivers antigen to dendritic cells (DCs). The potentially clinical application of this limited by its murine origin. Traditional humanization method such as complementarity determining regions (CDRs) graft often leads decreased or even lost affinity. Here we have developed novel based on computer modeling bioinformatics analysis. First, used homology technology build the precise model Fab. A epitope...
Abstract Designing and optimizing the interface of carbon fiber composites is key to improve mechanical biotribological properties. Carbon fiber‐reinforced hydroxyapatite‐epoxy matrix (CM) composites, which have excellent properties, are often used avoid artificial bone damage longevity bone. In this work, a SiC nanowires@pyrolytic (SiCnws@PyC) designed incorporated into CM SiCnws@PyC can promote bonding fiber/matrix cohesion epoxy matrix. The properties greatly improved because modification...
Osteoporosis, a chronic disease with no therapeutic cure, affects growing number of people as the aging population in China rapidly increases. Therefore, developing an evidence-based model health education and management for osteoporosis prevention is required. In present study, club was established, which novel prevention. A unified membership used based on digitized database. total 436 patients were randomly assigned to group or self-management control group. For group, multiple activities...
The mitral valve, which lies between the left atrium and ventricle, plays an important role in controlling uniflux of blood from to ventricle as one four human heart valves. A precise description shape valve has vital significance studying its physiological structure periodic movement. Unsatisfyingly, there is almost no unified mathematical same literature. In this paper, we present a geometric model for elastic shell with special shape. Parametric equations are provided, including anterior...
Carbon fiber reinforced dual-matrix composites (CHM) including carbon hydroxyapatite-polymer matrix (CHMP) and hydroxyapatite-pyrolytic (CHMC) have great potential application in the field of artificial hip joints, where a combination high mechanical strength excellent biotribological property are required. In this work, graphene-silicon nitride nanowires (Graphene-Si3N4nws) interlocking interfacial enhancement were designed constructed into CHM for boosting properties. The graphene Si3N4nws...
In this study, we constructed a novel and simple yeast surface display system with single expression vector. The newly established uses bidirectional vector carrying the AGA 1 gene driven by PGK promoter in one direction 2‐expression cassette TEF reverse direction, geneticin, G418‐resistant gene, as selection marker for transformants. Because all elements are put into vector, new is much simpler to use, there no need any genetic modification of host strains; therefore, can be used wild type...
Multimorbidity has become a global public health concern. Knowledge about the prevalence and patterns of multimorbidity will provide essential information for intervention clinical management. This study aimed to examine gender socioeconomic differences in among nationally representative sample middle-aged older Chinese individuals.Data were obtained from 2018 wave China Health Retirement Longitudinal Study. Latent class analysis was conducted discriminate patterns. Multinomial logit...
Abstract Aim To understand the status of internalized stigma in patients with rheumatoid arthritis (RA) and explore its relationship self‐esteem, social support, coping style. Methods This cross‐sectional study selected RA who visited Rheumatology Immunology Department a tertiary hospital from May 2022 to 2023. The Chinese versions Internalized Stigma Mental Illness Scale‐Rheumatoid Arthritis (ISMI‐RA), Social Support Rating Scale, Rosenberg Self‐Esteem Medical Coping Style Questionnaire...
Globally, blood pressure management strategies were ineffective, and a low percentage of patients receiving hypertension treatment had their controlled. In this study, we aimed to build medication prediction model by correlating patient attributes with medications help physicians quickly rationally match appropriate medications. We collected clinical data from elderly hypertensive during hospitalization combined statistical methods machine learning (ML) algorithms filter out typical...
Abstract Background and purpose Alcohol-induced osteonecrosis of the femoral head (ONFH) is a complex heterogeneous disease. Genetic factors epigenetic modifications are one pathogenesis However, influence on disease has not been systematically studied. Our research aims to determine methylation changes alcohol-induced ONFH. Methods An analytical cross-sectional study Chinese male population (50 ONFH patients 50 controls). The EpiTYPER Sequenom MassARRAY platform was used detect DNA status...
Steroid-induced osteonecrosis of the femoral head (ONFH) is a disease bone. Metabolism and genetic factors are generally considered to play an important role. The purpose this study was investigate relationship between single-nucleotide polymorphisms (SNPs) in MIR17HG MIR155HG risk steroid-induced ONFH population northern China.A total 199 patients 506 healthy controls were recruited for study. Four SNPs seven genotyped by Sequenom MassARRAY. ORs 95% CIs used evaluate these ONFH.In...
Abstract The Research Experiences for Undergraduates (REU) program plays a crucial role in fostering research interests among undergraduate students, motivating them to pursue advanced degrees Science, Technology, Engineering, and Mathematics (STEM) fields, developing diverse, skilled workforce STEM careers. Annually, the National Science Foundation (NSF) awards approximately 170-190 REU grants. funding sites often reflects current trends research. Our study aims examine sites' contributions...
Objectives The objective of this study was to examine the impact athletes achieving excellence at different ages (excellent age) on their subsequent performance development. aim deepen understanding interplay among talent, training, and athletes’ Additionally, aimed provide insights for athletics coaches better identify talent devise more effective personalized long-term training plans. Design This a cross-sectional study. Method A hierarchical linear model employed analyze correlation...
Abstract Background : Steroid-induced osteonecrosis of the femoral head (ONFH) is aseptic necrosis caused by glucocorticoid use. Once necrotic occurs, it irreversibly affects quality life seriously. Studies have shown that susceptibility to steroid-induced ONFH likely be related variation miRNA coding genes. Therefore, this study aimed was investigate effect MIR3142HG on ONFH. Methods Agena MassARRAY used genotype gene rs1582417, rs2431689, rs7727155 and rs17057846 in 199 patients 506...