About
Contact & Profiles
A5038981147
Research Areas
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
Boston Children's Hospital
2024
Harvard University
2024
Tumors develop strategies to evade immunity by suppressing antigen presentation. In this work, we show that prosaposin (pSAP) drives CD8 T cell-mediated tumor and its hyperglycosylation in dendritic cells (DCs) leads cancer immune escape. We found lysosomal pSAP single-saposin cognates mediated disintegration of cell-derived apoptotic bodies facilitate presentation membrane-associated cell activation. the microenvironment, transforming growth factor-β (TGF-β) induced subsequent secretion,...
10.1126/science.adg1955
article
EN
Science
2024-01-11
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