A5089357533- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Forensic Toxicology and Drug Analysis
- Nicotinic Acetylcholine Receptors Study
- Chemical synthesis and alkaloids
- Veterinary Pharmacology and Anesthesia
- Pharmacology and Obesity Treatment
- Biochemical Analysis and Sensing Techniques
National Institute on Drug Abuse
2021-2024
Office of Extramural Research
2024
Abstract Rationale The potent synthetic opioid fentanyl, and its analogs, continue to drive opioid-related overdoses. Although the pharmacology of fentanyl is well characterized, there little information about reinforcing effects clandestine analogs (FAs). Objectives Here, we compared FAs acetylfentanyl, butyrylfentanyl, cyclopropylfentanyl on drug self-administration in male female rats. These feature chemical modifications at carbonyl moiety scaffold. Methods Sprague-Dawley rats fitted...
Psychedelics are a class of drugs that produce unique subjective effects via agonist actions at the 5-hydroxytryptamine 2A receptor (5-HT2A). The 5-HT2A-mediated head twitch response (HTR) in rodents is used as reliable proxy for psychedelic drug activity humans, but existing methods measuring HTRs require surgery or time-consuming visual scoring. In present work, we validated simple noninvasive method quantitating using computer-based analysis experimental video recordings. Male C57BL/6J...
HYPOTHESIS Phenethylamine analogs are often found in dietary supplements, even though they rarely listed on the ingredient label. Due to their structural similarities amphetamine, it is anticipated that these compounds display comparable pharmacological effects amphetamine and other stimulants. Here, we compared of selected phenethylamine drug self-administration behavior rats. METHODS Male Sprague-Dawley rats fitted with intravenous (i.v.) jugular catheters were placed experimental chambers...