A5022749374- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Click Chemistry and Applications
- Synthesis and Biological Evaluation
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Analysis
- Oxidative Organic Chemistry Reactions
- Cyclopropane Reaction Mechanisms
- Chemical Reaction Mechanisms
- Coenzyme Q10 studies and effects
- Organic Chemistry Cycloaddition Reactions
- 3D Printing in Biomedical Research
- Quinazolinone synthesis and applications
- Carbohydrate Chemistry and Synthesis
- Catalytic Alkyne Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Sulfur-Based Synthesis Techniques
- Chemical synthesis and alkaloids
- Multicomponent Synthesis of Heterocycles
- Asymmetric Hydrogenation and Catalysis
- Synthetic Organic Chemistry Methods
Polish Academy of Sciences
2013-2022
Institute of Organic Chemistry
2018-2021
University of Warsaw
2012-2020
Warsaw University of Technology
2016-2019
Faculty (United Kingdom)
2016
National Veterinary Research Institute
2013
Technical University of Munich
2003
Bauhaus-Universität Weimar
2003
Library of Congress
2003
Abstract In recent years, spirocyclic compounds have attracted a significant interest in medicinal chemistry due to their considerable biological activities. The general and widely used concept for compound synthesis is related with dearomatization of starting material. However, most the libraries prepared using this comprise structure similarity. Therefore, preparation structurally distinct comprising varied functionality requires different approaches that includes non‐dearomative pathways....
The synthesis of an easily accessible theophylline-derived copper complex with additional ammonium functionalization has been developed.
The synthesis of a family N‐heterocyclic carbene–copper complexes bearing sulfur moiety by using different copper(I) halides through convenient procedures is reported. solid‐state structures the presented copper compounds were elucidated based on X‐ray crystallographic analysis. obtained examined in various catalytic transformations including 1,3‐dipolar cycloaddition alkynes and azides, A 3 coupling reaction, β‐hydroboration.
A visible-light-mediated process for dehydrogenation of amines has been described. The given protocol showed a broad substrate scope, mild reaction conditions and excellent results without the requirement tedious purification.
A series of modified Hoveyda–Grubbs catalysts incorporating a chelating iodo-benzylidene ligand were prepared and characterized. The presence electron-withdrawing ring substituents in the para position to iodide was found decrease catalytic activity, revealing that dissociation Ru⋯I–Ar bond is not rate-determining step.
Abstract N ‐Aryl‐substituted 2‐nitrosoanilines (=2‐nitrosobenzenamines) 1 , readily available by nucleophilic substitution of the ortho ‐H‐atom in nitroarenes with arenamines, react 2‐substituted acetic acid esters presence a weak base giving 1‐arylquinoxalin‐2(1 H )‐ones ( Scheme 2 ). This cyclocondensation allows for synthesis compounds – 4 unsubstituted at C(3) or substituted alkyl, aryl, ester, amide, and keto groups, good to excellent yields Tables
Multicomponent reactions including Biginelli reaction and A 3 coupling are useful synthetic methodologies as they can provide valuable intermediates building blocks for the synthesis of bioactive natural compounds. The heterocyclic products these transformations represent antibacterial, antitumor or anti‐inflammatory properties. In presented study, copper‐mediated protocols in sustainable solvents were reported. At first, charged NHC copper complexes synthesized few steps characterized using...
A series of N ‐heterocyclic copper carbene complexes bearing sulfoxide and sulfone moieties have been prepared. In case new compounds with ligand, the solid‐state structures were determined using X‐Ray crystallography. Obtained investigated as catalysts in such transformations as: 1,3‐dipolar cycloaddition alkynes azides (CuAAC), 3 coupling reaction β‐hydroboration compared standard catalytic systems.
The visible‐light‐mediated oxygenation of 3‐ N , ‐(dimethylaminomethyl)‐indoles bearing various substituents afforded a series 3‐carbaindole derivatives. Herein we describe the reaction scope, plausible mechanism and practical application this transformation in formal synthesis (–)‐vincorine is described as well.
An efficient catalytic propargylation of CoQ0 is described by employing the cooperative effect Sc(OTf)3 and Hantzsch ester. It suggested to work through redox chain reaction, which involves hydroquinone dimeric propargylic moiety intermediates. A broad range alcohols can be converted into appropriate derivatives containing triple bonds in good excellent yields. The mechanism given transformation also discussed.
Abstract The new catalyst is found to be active in alkyne‐azide cycloaddition reactions (CuAAC) leading compound (III) and Glaser homo‐coupling (V) aqueous media at room temperature.
Endothelial cells (ECs) play a significant role in healthy and dysfunctional state, the latter is correlated with range of lifestyle diseases, such as cardiovascular disorders or some cancers. Therefore, knowledge cellular metabolism, especially glucose important from point view studying disease mechanisms. The metabolism uptake may reflect physiopathological conditions cell activity energy metabolism. Our method choice for changes at subcellular level Raman microscopy to investigate...
Abstract Die 4‐Diazoacetylazetidinone (II), erhalten unter den Bedingungen der Arndt‐Eistert‐Reaktion aus Carbonsäuren (I), liefern bei Bestrahlen in Acetonitril/HgO die Titelverbindungen (III).