A5058448623- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- Arsenic contamination and mitigation
- Microscopic Colitis
- Inflammatory Bowel Disease
- Neurological disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Vagus Nerve Stimulation Research
- Advanced Causal Inference Techniques
- Nosocomial Infections in ICU
- Energy and Environment Impacts
- Prenatal Substance Exposure Effects
- Epilepsy research and treatment
- Diagnosis and treatment of tuberculosis
- Cardiac pacing and defibrillation studies
- Clostridium difficile and Clostridium perfringens research
- Pregnancy and Medication Impact
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Noise Effects and Management
- Statistical Methods and Inference
- Smoking Behavior and Cessation
- Nutritional Studies and Diet
Ithaka Harbors
2023-2025
Thermo Fisher Scientific (Canada)
2023
Dartmouth College
2019-2022
Hanover College
2021
Dartmouth Hospital
2019
White River Junction VA Medical Center
2018-2019
Understanding the relationship among changes in Clinical Dementia Rating (CDR), patient outcomes, and probability of progression is crucial for evaluating long-term benefits disease-modifying treatments. We examined associations Alzheimer's disease (AD) stages outcomes that are important to patients their care partners including activities daily living (ADLs), geriatric depression, neuropsychiatric features, cognitive impairment, probabilities being transitioned a facility (i.e.,...
Prenatal exposure to arsenic has been linked a range of adverse health conditions in later life. Such fetal origins disease are frequently the result environmental effects on epigenome, leading long-term alterations gene expression. Several studies have demonstrated prenatal DNA methylation; however impact generation and decoding post-translational histone modifications (PTHMs) is less well characterized, not studied context human exposures.In current study, we examined effect...
Unmeasured confounders are commonplace in observational studies conducted using real-world data. Prior event rate ratio (PERR) adjustment is a technique shown to perform well addressing such confounding. However, it has been demonstrated that, some circumstances, the PERR method actually increases rather than decreases bias. In this work, we seek better understand robustness of adjustment.We begin with Bayesian network representation generalized study, which subject unmeasured Previous work...
Accurate assessment of tobacco smoke exposure is key to evaluate its effects. We sought validate and establish cut-offs for self-reported smoking secondhand (SHS) during pregnancy using urinary cotinine 4-(methylnitrosamino)-1-(-3-pyridyl)-1-butanol (NNAL) in a large contemporary prospective study from the USA, with lower prevalence than has previously been evaluated. Prospective birth cohort. Pregnancy clinics New Hampshire Vermont, USA. 1396 women enrolled Birth Cohort Study smoking,...
As part of the New Hampshire Birth Cohort Study, children 3 to 5 years age participated in a personal PM2.5 exposure study. This paper characterizes and protocol compliance measured with wearable sensor. The MicroPEM™ collected continuous integrated measures data on 272 children. PM2.5, black carbon (BC), brown tobacco smoke (BrC-ETS) was from filters. We performed multivariate analysis woodstove presence other factors that influenced BC, BrC exposures. valid 258 participants (95%). Children...
Abstract Objective: Clostridioides difficile infection (CDI) remains a significant public health concern, resulting in excess morbidity, mortality, and costs. Additional insight into the burden of CDI adults aged <65 years is needed. Design/Setting: A 6-year retrospective cohort study was conducted using data extracted from United States Veterans Health Administration electronic medical records. Patients/Methods: Patients 18–64 on January 1, 2011, were followed until incident CDI, death,...
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Retrospective data harmonization across multiple research cohorts and studies is frequently done to increase statistical power, provide comparison analysis, create a richer source for mining. However, when combining disparate sources, projects face management analysis challenges. These include differences in the dictionaries variable definitions, privacy concerns surrounding health representing sensitive populations, lack of properly defined models. With availability mature open-source...
Introduction: Real-world data comparing the clinical effectiveness and safety of vedolizumab (VDZ) ustekinumab (UST) in patients (pts) with late Crohn’s Disease (CD, a disease duration ≥2 years) is limited. Methods: EVOLVE Expansion (NCT05056441) was multicenter, observational, retrospective medical chart review study Australia, Belgium, Switzerland from 2016 to 2021 which biologic-naïve pts CD (≥18 years old) initiated first-line biologic treatment VDZ or UST were included. In this...
Introduction: There is limited data comparing real-world clinical effectiveness and safety of vedolizumab (VDZ) ustekinumab (UST) in patients (pts) with early Crohn’s Disease (CD, a disease duration ≤2 years). Methods: EVOLVE Expansion (NCT05056441) was multicenter, observational, retrospective medical chart review study biologic-naïve pts CD (≥18 years old) who initiated VDZ or UST treatment Australia, Belgium, Switzerland from 2016 to 2021. This analysis looked at outcomes (disease years)...
Abstract Background Despite the widespread availability of several injectable inactivated influenza vaccines (IIV), including trivalent standard-dose (IIV3-SD) and high-dose (IIV3-HD), quadrivalent (IIV4), US Advisory Committee on Immunization Practices does not currently recommend one over another. The objective this study was to assess relative vaccine effectiveness (rVE) IIV3-HD IIV4 vs. IIV3-SD. Methods rVE estimated from a retrospective cohort Veterans aged 65 years older who received...
PDS 73: Neurological effects, Johan Friso Foyer, Floor 1, August 26, 2019, 10:30 AM - 12:00 PM Background: Behavioral effects of early life exposure to several neurotoxic metals are incompletely understood. Methods: We investigated periconceptional and prenatal metals, metalloids, other trace elements in relation child behavior the New Hampshire Birth Cohort Study, an ongoing prospective rural birth cohort study enrolling pregnant women with private wells for household water. Toxic (Pb, Hg,...