Leptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the former stimulate whereas latter inhibit it. The objective was to analyze association of LEP A19G ADIPOQ+45 T/G +276 G/T polymor

We examined the influence of Arg194Trp, Arg280His, and Arg399Gln polymorphisms XRCC1 (X-ray repair cross-complementing group 1) on development childhood acute lymphoblastic leukemia (ALL) in 120 ALL patients controls Mexico. All them were genotyped for these polymorphisms, using polymerase chain reaction. No significant differences allele genotype frequencies any polymorphism observed between controls. Estimation haplotypes showed eight expected (A-H), seven which found both controls;...

DNA repair proteins maintain integrity; polymorphisms in genes coding for these can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G XRCC1 Arg194Trp Arg399Gln with CRC Mexican patients. Genomic samples were obtained from peripheral blood 108 individuals (study group) at diagnosis 120 donors (control Western Mexico; both groups mestizos. The detected by PCR-RFLP. Association was estimated calculating the odds ratio...

To determine the influence of MDR1 C3435T polymorphism on development childhood acute lymphoblastic leukemia (ALL), we studied 107 children with ALL and 111 healthy subjects. All subjects were genotyped for using polymerase chain reaction–restriction fragment length method. The genotype frequencies in patients 17% homozygous CC, 61% heterozygous CT, 22% TT; individuals 14% 53% 33% TT. In allele 0.47 C 0.53 T allele; group these 0.40 0.60 alleles, respectively. No significant differences...

Abstract The osteochondrodysplasias represent a heterogeneous group of cartilage and bone diseases. Among these, achondrogenesis 1B, atelosteogenesis type II, diastrophic dysplasia, autosomal recessive multiple epiphyseal dysplasia are caused by mutations in the solute carrier family 26 (sulfate transporter), member 2 gene ( SLC26A2 ). This shows continuous spectrum clinical variability shares many features common. Usually, it is difficult to distinguish clinically among these patients. To...

Summary Background Methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms have been associated with overweight people and obesity. The goal of this study was to investigate the relationship 677C>T polymorphism obesity biochemical variables in young individuals Mexico. Methods A total 316 were included study, 172 normal weight (NW) 144 over weight/obesity. Body mass index (BMI) classified as NW, overweight, Also, waist circumference measured. Moreover, glucose, cholesterol,...

Background Adiponectin protein and some variations in its gene, ADIPOQ have recently been associated with cancer because they regulate glucose lipid metabolism as well anti-apoptotic anti-inflammatory proteins. Aim The aim of this study was to analyse the relationship between selected biochemical markers, anthropometric indices rs2241766 rs1501299 SNPs ductal infiltrating breast (DIBC) a Mexican population. Methods This cross-sectional included 64 DIBC patients 167 healthy women. Polymerase...

We investigated whether the MDR1 C3435T polymorphism is associated with fibrocystic changes (FCC), infiltrating ductal breast cancer (IDBC), and/or clinical-pathological features of IDBC in Mexican patients.Samples from women who received surgical treatment 2007 at Centro Médico de Occidente (México) were included analysis.Genotyping was performed by polymerase chain reaction-restricted fragment length polymorphisms 64 paraffin-embedded samples IDBC, FCC, and 183 peripheral blood healthy...

Abstract Introduction Beckwith–Wiedemann syndrome is an overgrowth that characterized by hypoglycemia at birth, coarse face, hemihypertrophy and increased risk to develop embryonal tumors. In approximately 15% of patients, the inheritance autosomal dominant with variable expressivity incomplete penetrance, whereas remainder cases are sporadic. molecular etiologies complex involve two imprinting centers 1 (IC1) 2 (IC2) 11p15 region. This case report describes, for first time, unusual...

We analyzed a possible association between RUNX3 gene polymorphisms and haplotypes in Mexican patients with colorectal cancer (CRC).Genomic DNA samples were obtained from the peripheral blood of 176 CRC at diagnosis 195 individuals that formed control group.The detected by polymerase chain reaction-restriction fragment length polymorphism.Association was estimated odds ratio (OR).The linkage disequilibrium ©FUNPEC-RP www.funpecrp.com.brGenetics Molecular Research 14 (4): 15505-15510 (2015)...

Colorectal cancer is the second cause of death by around world. Sporadic colorectal most frequent (75%), and it produced interaction environmental, epigenetic, genetic factors. The accumulation single-nucleotide variants in genes associated with cell proliferation, DNA repair, and/or apoptosis could confer a risk to cancer. aim this study was analyze gene-gene interactions among CCND2 (rs3217901), CDKN1A (rs1059234 rs1801270), POLD3 (rs3824999) Mexican patients We collected peripheral blood...

Colorectal cancer (CRC) is the third most common and one of main causes death around world. Multiple lines evidence have suggested role corticotropin-releasing hormone (CRH) family in CRC induction, including low expression receptor 2 (CRHR2), which an angiogenesis inhibitor inflammatory modulator. Previous research suggests that CRHR2 colonic intestinal cells can regulate migration, proliferation apoptosis through modulation several pathways. The aim this study was to analyze association...

To determine the influence of MDR1 C3435T polymorphism on development childhood acute lymphoblastic leukemia (ALL), we studied 107 children with ALL and 111 healthy subjects. All subjects were genotyped for using polymerase chain reaction–restriction fragment length method. The genotype frequencies in patients 17% homozygous CC, 61% heterozygous CT, 22% TT ; individuals 14% 53% 33% TT. In allele 0.47 C 0.53 T allele; group these 0.40 0.60 alleles, respectively. No significant differences...

Colorectal cancer (CRC) is one of the most common cancers worldwide. Its etiopathogenesis complex, mainly influenced by genetic instability caused accumulation mutations. The XRCC1 gene, which involved in DNA repair, has been associated with CRC through R194W (C194T) and R399Q (G399A) polymorphisms, but results are inconsistent. Here, we analyzed association these polymorphisms sporadic a northeastern Mexican population, including 155 male patients controls. Genotyping was performed using...

Colorectal cancer (CRC) is a complex disease due to the large number of factors that influence its development, including variants in tumor suppressor genes. To estimate allelic and genotypic frequencies c.3915G>A c.5371G>A TSC2 gene Mexican population with CRC, as well analyze their association development CRC. 126 peripheral blood samples from patients diagnosed sporadic CRC 134 healthy individuals, regarded control group, were included. Identification genotypes was carried out using...

Obesity and colorectal cancer could be linked by adipocytokines, which are proteins associated with cell proliferation. High levels of the adipocytokine leptin promote development through its receptor.To determine association between c.326A>G c.668A>G LEPR gene polymorphisms cancer.DNA was extracted from peripheral blood 147 patients sporadic 134 healthy people. Genotypes were obtained PCRRFLP determined odds ratio (OR) test using SPSS™, version 10.0, program. Haplotype frequencies linkage...

This study aimed to summarize the epidemiological and clinical features of thyroid function in COVID-19 patients intensive care unit (ICU) Civil Fray Antonio Alcalde Hospital Mexico.This is a cross-sectional that included 63 ICU with from August 2021 December 2021. Thyroid was evaluated through TSH, T4, T3, FT3 measures. Comorbidities such as diabetes mellitus type 2 (T2DM), arterial hypertension (HT), body mass index (BMI), biochemical biomarkers, including procalcitonin (PCT) C reactive...

The present study aimed to analyze the methylation pattern of MIR200 family in colorectal tissues and peripheral blood cancer (CRC) patients. Previous informed consent, 102 samples (tumor adjacent normal tissues) 40 were collected from CRC Additionally, we included a reference group samples. DNA extraction was done for blood. For methylation-specific PCR, used bisulfite-treated controls methylated unmethylated each assay. PCR fragments separated by 6% polyacrylamide gel electrophoresis....

ResumenIntroducción: El cáncer colorrectal (CCR) es una enfermedad compleja debido al gran número de factores que influyen en su desarrollo, incluyendo variantes genes supresores tumores.Objetivo: Estimar las frecuencias alélicas y genotípicas c.3915G>A c.5371G>A del gen TSC2 población mexicana con CCR, así como analizar la asociación el desarrollo CCR.Métodos: Se incluyeron 126 muestras sangre periférica pacientes diagnóstico CCR esporádico 134 individuos sanos, considerados grupo...