A5082087861- Analytical Methods in Pharmaceuticals
- Antibiotics Pharmacokinetics and Efficacy
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Analytical Chemistry and Chromatography
- Phytochemistry and Biological Activities
- Pharmaceutical studies and practices
- Essential Oils and Antimicrobial Activity
- Advancements in Transdermal Drug Delivery
- Pharmacogenetics and Drug Metabolism
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects of Natural Compounds
- Estrogen and related hormone effects
- Diabetes Management and Research
- Inflammatory mediators and NSAID effects
- Pneumonia and Respiratory Infections
- Sulfur Compounds in Biology
- Pesticide Residue Analysis and Safety
- Pharmaceutical Practices and Patient Outcomes
- Crystallization and Solubility Studies
- Natural Compound Pharmacology Studies
- Vitamin C and Antioxidants Research
- Medicinal Plant Extracts Effects
- Psidium guajava Extracts and Applications
University of Peshawar
2012-2024
Shifa Tameer-e-Millat University
2022
Sarhad University of Science and Information Technology
2017
The aim of the study was to design and formulate an antibody-mediated targeted, biodegradable polymeric drug delivery system releasing in a controlled manner achieve therapeutic goal for effective treatment breast cancer. Antibody-mediated paclitaxel-loaded PLGA nanoformulations were prepared by solvent evaporation method using different experimental parameters compatibility studies. optimized formulations selected vitro vivo evaluation cytotoxicity release studies show biphasic pattern...
Microneedles have recently emerged as a promising platform for delivering therapeutic agents by disrupting the skin, resulting in improved and high drug delivery via this route. Ibuprofen is widely used topically orally chronic pain conditions; to avoid untoward gastric effects, topical application preferred over oral This study aimed enhance solubility of poorly water-soluble ibuprofen using Soluplus (SP) solubilizer fabricate dissolving microneedle patches drug. The fabricated were...
The SeDeM expert system is a pre formulation tool applied for the prediction of suitability material direct compression. This innovative provides an index good compressibility indicating its aptitude to be compressed by In study has been behavior used in effervescent tablets Different formulations were developed on basis results system. Various parameters as per determined according their official and reported methods. Powder blend different was evaluated rheological properties while various...
The aim of this study is to formulate polymeric paclitaxel nanoparticles with various stabilizers improve solubility, enhance stability, maximize therapeutic efficacy and minimize detrimental toxicities paclitaxel. In study, trastuzumab-guided poly lactic-co-glycolic acid (PLGA)-loaded were formulated pluronic F-127, polyvinyl alcohol (PVA), poloxamer 407, Tween-80, span 20, sodium dodecyl sulfate (SDS), lauryl (SLS) at different concentrations (0.5, 1, 1.5 2%) using the solvent evaporation...
Glimepiride (GM) is a hydrophobic drug that dissolves slowly and yields inconsistent clinical responses after oral administration. Transdermal delivery (TDD) an appropriate alternative to Microneedles (MNs) offer promising system penetrates the skin, while polymeric micelles can enhance solubility; hence, combination of both results in high bioavailability. This study aims improve glimepiride's solubility, dissolution rate, bioavailability by incorporating nanomicelles into MNs for TDD. The...
The objective of the current work was to develop and evaluate thermoreversible subcutaneous drug delivery system for Insulin. Thermoreversible in-situ gel developed evaluated both in-vitro in-vivo comprising pluronic F-127 alone or in combination with methylcellulose different ratios. release kinetics mechanism predicted by applying various mathematical models dissolution data. Rabbits were used as animal model following injection predict pharmacokinetic parameters Pk-Summit® software. data...
A simple and economical reversed phase HPLC-UV method was developed for omeprazole (OMP) its two main metabolites, 5-Hydroxy (5-OH-OMP) sulfone (OMP-S) in human plasma using pantoprazole as the internal standard. After optimization of various chromatographic conditions experimental parameters, validated according to standard guidelines. The separation all analytes achieved on a Supelco C18 column methanol phosphate buffer (pH 7.2) ratio (42:58, v/v) mobile isocratic mode at flow rate 0.8...
AbstractA novel liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed for the determination of rosuvastatin (rosuva) and its metabolite N-desmethyl (NDM-rosuva) in human plasma using atorvastatin as internal standard. The validated according to international guidelines. analytical column used HiChrom® C18 (150 × 3.0 mm, 3 µm; Reading, UK) mobile phase comprised 0.1% formic acid acetonitrile water (70:30 v/v), pumped at 300 µL/min. precipitation proteins extraction...
Background: Cocrystals are an efficient way for the delivery of low soluble drugs but when dissolved they rapidly disproportionate. To formulate cocrystals in tablets, must be stabilized. In this study ibuprofen-nicotinamide (IBU-NIC) were synthesized initially by slow solvent evaporation and bulk production fast techniques. Method: The characterized powder X-ray diffraction (PXRD), Fourier transform infrared spectrophotometer (FTIR), differential scanning calorimetry (DSC),...
Context: Eremostachys laciniata (L.) Bunge (Lamiaceae), which has been reported as a rich source of flavonoids, is one the rarely explored species genus Eremostachys.
A new method has been developed and validated based on high-performance liquid chromatography for simultaneous determination of endogenous aminothiols (cystine, cysteine, homocystiene, methionine, reduced oxidized glutathione, N-acetylcysteine), ascorbic acid, malondialdehyde in single elution using electrochemical detector kept at 900 mV electrode potential Discovery 250 mm C18 RP chromatographic column. The time was 20 min, flow rate 0.6 mL/min, injecting 5 µL sample analysis after...