A5044688698- Galectins and Cancer Biology
- Amoebic Infections and Treatments
- Eosinophilic Esophagitis
- Protein Tyrosine Phosphatases
- Glycosylation and Glycoproteins Research
- Inflammasome and immune disorders
Institute of Biological Chemistry, Academia Sinica
2021-2024
National Taiwan Normal University
1993
Significance Cytosolic lipopolysaccharides (LPSs) induce oligomerization of caspase-4/5/11, resulting in pyroptosis, but the involvement any other host resistance factors this process is unknown. Galectins bind to components pathogenic microorganisms, particularly LPSs, a glycan-dependent manner. However, these proteins are mainly present intracellularly, and little known regarding their functions associated with binding including cytosol. Here, we report that galectin-3 recognizes cytosolic...
Galectin-4, a member of the galectin family animal glycan-binding proteins (GBPs), is specifically expressed in gastrointestinal epithelial cells and known to be able bind microbes. However, its function host-gut microbe interactions remains unknown. Here, we show that intracellular galectin-4 intestinal (IECs) coats cytosolic Salmonella enterica serovar Worthington induces formation bacterial chains aggregates. Galectin-4 enchains bacteria during their growth by binding O-antigen...