A5011476589- Spinal Cord Injury Research
- Neuroscience of respiration and sleep
- Transcranial Magnetic Stimulation Studies
- Neonatal Respiratory Health Research
- Sleep and Wakefulness Research
- Nerve Injury and Rehabilitation
- Cardiovascular Issues in Pregnancy
- Neonatal and fetal brain pathology
- Heart Rate Variability and Autonomic Control
Scuola Internazionale Superiore di Studi Avanzati
2020-2025
University of Udine
2022-2025
Abstract Moderate and acute intermittent hypoxia (IH) facilitates respiration in adults, mostly by recruiting peripheral chemo‐/baroreceptors. As central chemoreceptors are widely expressed immature brains, we hypothesized that IH modulates at birth through a purely neurogenic mechanism involving the hypothalamus. The nervous system (CNS) isolated from 0‐ to 3‐day‐old rats was perfused with four eight brief (5 min) bouts of mild‐hypoxic/normocapnic modified Krebs solution, intermingled 5‐min...
Abstract Several spinal motor output and essential rhythmic behaviors are controlled by supraspinal structures, although their contribution to neuronal networks for respiration locomotion at birth still requires better characterization. As preparations of isolated brainstem only focus on local circuitry, we introduced the in vitro central nervous system (CNS) from neonatal rodents simultaneously record a stable respiratory rhythm both cervical lumbar ventral roots (VRs). Electrical pulses...
Abstract Exercise modifies respiratory functions mainly through the afferent feedback provided by exercising limbs and descending input from suprapontine areas, two contributions that are still underestimated in vitro. To better characterize role of limb afferents modulating respiration during physical activity, we designed a novel experimental vitro platform. The whole central nervous system was isolated neonatal rodents kept with hindlimbs attached to an ad-hoc robot (Bipedal Induced...
Although epidural spinal stimulation (ESS) results in promising therapeutic effects individuals with cord injury (SCI), its potential to generate functional motor recovery varies between and remains largely unclear. However, both preclinical clinical studies indicate the capacity of electrical pharmacological interventions synergistically increase engagement sensorimotor networks regain function after SCI. This study explored whether selective antagonism adenosine A1 receptor subtype...
Highly varying patterns of electrostimulation (Dynamic Stimulation, DS) delivered to the dorsal cord through an epidural array with 18 independent electrodes transiently facilitate corticospinal motor responses, even after spinal injury. To partly unravel how input are affected by DS, we introduced a platform that allows selective cortical stimulation during multisite acquisition dorsum potentials (CDPs) and simultaneous supply DS. Firstly, interface was validated classical distribution CDPs...
ABSTRACT Several spinal motor output and essential rhythmic behaviors are controlled by supraspinal structures. Although of great advantage in deciphering their functional organization, existing preparations the isolated brainstem networks only focus on local circuitry. The goal our study has been to better characterize contribution higher centers neuronal involved respiration locomotion. Thus, a novel vitro preparation from CNS neonatal rodents was introduced simultaneously record stable...