A5029805964- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Drug Solubulity and Delivery Systems
- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Pharmacogenetics and Drug Metabolism
- Malaria Research and Control
- Sulfur Compounds in Biology
- Antibiotics Pharmacokinetics and Efficacy
- HIV/AIDS drug development and treatment
- Pregnancy and preeclampsia studies
- Neuroscience and Neuropharmacology Research
- DNA and Nucleic Acid Chemistry
- Immunotherapy and Immune Responses
- Chronic Myeloid Leukemia Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Olfactory and Sensory Function Studies
- Cholesterol and Lipid Metabolism
- Metabolism and Genetic Disorders
- Opioid Use Disorder Treatment
- Pharmacological Effects and Assays
- Pharmacy and Medical Practices
- Advanced Chemical Sensor Technologies
Aston University
2016-2025
University of Manchester
2006-2014
The blood-brain barrier (BBB) serves to protect and regulate the CNS microenvironment. development of an in-vitro mimic BBB requires recapitulating correct phenotype in-vivo BBB, particularly for drug permeation studies. However majority widely used models demonstrate low transendothelial electrical resistance (TEER) poor phenotype. application shear stress is known enhance tight junction formation hence improve function. We utilised a high TEER primary porcine brain microvascular...
Caucasian population groups have a higher propensity to develop skin cancer, and associated clinical interventions often present substantial financial burden on healthcare services. Conventional treatments are not suitable for all patient as result of poor efficacy toxicity profiles. The primary objective this study was deformable liposomal formulation, the properties which being dictated by surfactant Tween 20, dermal cellular delivery epigallocatechin gallatein (EGCG), compound possessing...
Neurodegenerative diseases are often linked to oxidative stress (OS), which worsen neuroinflammation and cause neuronal damage. Managing OS with gasotransmitters such as hydrogen sulphide (H2S) is a promising therapeutic approach protecting brain cells from AP39, mitochondria-targeted H2S donor, has shown neuroprotective potential by reducing improving mitochondrial function. However, its clinical application limited due poor stability rapid release, necessitating drug delivery system...
Hydrogen sulphide (H
Central nervous system (CNS) drug disposition is dictated by a drug's physicochemical properties and its ability to permeate physiological barriers. The blood-brain barrier (BBB), blood-cerebrospinal fluid centrally located transporter proteins influence within the central system. Attainment of adequate brain-to-plasma cerebrospinal fluid-to-plasma partitioning important in determining efficacy acting therapeutics. We have developed physiologically-based pharmacokinetic model rat CNS which...
Abstract: Cardiovascular disease (CVD) is the leading cause of death among men and women worldwide. In CVD, hypertension dyslipidemia commonly coexist are managed through coadministration amlodipine atorvastatin, respectively. The case for fixed-dose combination (FDC) oral dosage forms orally disintegrating tablet (ODT) technology to enhance outcomes compliance strong. This work follows development characterization single FDC ODTs containing followed by bioequivalence comparison between...
Breast cancer resistance protein (BCRP/ABCG2) is a drug efflux transporter expressed at the blood cerebrospinal fluid barrier (BCSFB), and influences distribution of drugs into central nervous systems (CNS). Current inhibitors have failed clinically due to neurotoxicity. Novel approaches are needed identify new modulators enhance CNS delivery. This study examines 18 compounds (mainly phytoestrogens) as expression/function BCRP in an vitro rat choroid plexus BCSFB model.Modulators were...
Abstract Objective In this study, we develop and apply a high-throughput screening protocol to investigate the activity of non-ionic surfactants, with broad range hydrophilic–lipophilic balance values, against ABCB1-mediated efflux transport ABCC2-mediated transport. Methods Caco-2 cells were grown for 7 days in 96-well plates, then washed incubated test materials 2 h presence 2.5 μm either rhodamine 123 (R-123) or 5(6)-Carboxy-2′,7′ dichlorofluorescein diacetate as probes ABCB1 ABCC2,...
In recent years, the incidence of skin cancer has increased worldwide, presenting a significant burden on healthcare services. Chemotherapy intervention is often not appropriate for all patients due to localized adverse effects physiology. The aim this study was, therefore, consider development novel phytochemical-based deformable liposomal formulation suspended in an aqueous gel controlled-release naringenin. Naringenin antioxidant, free radical scavenger, anti-inflammatory agent, and...
Atomisation of an aqueous solution for tablet film coating is a complex process with multiple factors determining droplet formation and properties. The importance size efficient high quality final product has been noted in the literature, smaller droplets reported to produce smoother, more homogenous coatings whilst simultaneously avoiding risk damage through over-wetting core. In this work effect on coat characteristics was investigated using X-ray microcomputed tomography (XμCT) confocal...
Antimalarial therapy during pregnancy poses important safety concerns due to potential teratogenicity and maternal physiological biochemical changes gestation. Piperaquine (PQ) has gained interest for use in response increasing resistance towards sulfadoxine-pyrimethamine sub-Saharan Africa. Coinfection with HIV is common many developing countries, however, little known about the impact of antiretroviral (ARV) mediated drug-drug interaction (DDI) on piperaquine pharmacokinetics pregnancy....