A5023869823- Sulfur Compounds in Biology
- Advancements in Transdermal Drug Delivery
- COVID-19 Clinical Research Studies
- Obstructive Sleep Apnea Research
- Telomeres, Telomerase, and Senescence
- Amino Acid Enzymes and Metabolism
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Alcohol Consumption and Health Effects
- Hydrogen's biological and therapeutic effects
- Neuroscience of respiration and sleep
- Inflammatory Biomarkers in Disease Prognosis
- Genetics, Aging, and Longevity in Model Organisms
- COVID-19 Impact on Reproduction
- Water resources management and optimization
- Polar Research and Ecology
- Skin Protection and Aging
- Colorectal and Anal Carcinomas
- Anorectal Disease Treatments and Outcomes
- Contact Dermatitis and Allergies
- Iron Metabolism and Disorders
- Atherosclerosis and Cardiovascular Diseases
- Antibiotic Use and Resistance
- Dermatological and COVID-19 studies
- Ocular Surface and Contact Lens
Aston University
2019-2025
University of Delhi
2025
Guru Gobind Singh Medical College and Hospital
2024
Dayanand Medical College & Hospital
2024
Aston Medical (France)
2022
International Management Institute
2013
Caucasian population groups have a higher propensity to develop skin cancer, and associated clinical interventions often present substantial financial burden on healthcare services. Conventional treatments are not suitable for all patient as result of poor efficacy toxicity profiles. The primary objective this study was deformable liposomal formulation, the properties which being dictated by surfactant Tween 20, dermal cellular delivery epigallocatechin gallatein (EGCG), compound possessing...
Increased accumulation of senescent cells with aging is associated reduced ability insulin-target tissues to utilize glucose, resulting in increased insulin resistance and glucotoxicity. We investigated the role senescent-associated secretory phenotype (SASP) within C2C12, skeletal muscle on glucose homeostasis if such effects could be by blocking pro-inflammatory pathways. C2C12 myotubes were treated 40% conditioned media from fibroblasts. Indirect uptake glycogen content measured. The...
Neurodegenerative diseases are often linked to oxidative stress (OS), which worsen neuroinflammation and cause neuronal damage. Managing OS with gasotransmitters such as hydrogen sulphide (H2S) is a promising therapeutic approach protecting brain cells from AP39, mitochondria-targeted H2S donor, has shown neuroprotective potential by reducing improving mitochondrial function. However, its clinical application limited due poor stability rapid release, necessitating drug delivery system...
Hydrogen sulphide (H
Objective: To investigate lactate dehydrogenase/Albumin to-urea (LAU) ratio as a potential predictor for COVID-19-induced fatal clinical complications in hospitalized patients. Methods: This is retrospective study involving blood analyses from 1139 hospitalised COVID-19 infection survivors and 349 deceased cases post-COVID-19 infection. Laboratory tests included complete picture, inflammatory markers, routine organ function tests. Results: The non-survivor group showed lower haemoglobin (p <...
In recent years, the incidence of skin cancer has increased worldwide, presenting a significant burden on healthcare services. Chemotherapy intervention is often not appropriate for all patients due to localized adverse effects physiology. The aim this study was, therefore, consider development novel phytochemical-based deformable liposomal formulation suspended in an aqueous gel controlled-release naringenin. Naringenin antioxidant, free radical scavenger, anti-inflammatory agent, and...
Self-medication (SM) is a growing phenomenon worldwide that has recently been classified as one of the most serious public health problems. SM can result in an incorrect self-diagnosis, inappropriate treatment, potential adverse reactions, interactions, and masking more sinister disease.To assess prevalence practices amongst healthcare professionals general population Saudi Arabia to identify sociodemographic contributing factors this practice.A total 540 participants were enrolled study....
Hydrogen sulphide (H2S) is an endogenous gaseous signalling molecule observing cardioprotective qualities in various experimental models. However, its therapeutic application limited due to rapid release vivo and potential toxicity. Controlled-release nanoparticles (NPs), such as polylactic-co-glycolic acid (PLGA) NPs entrapping H2S compounds may address these issues. PLGA NPs' encapsulating sodium thiosulphate (STS), a donor, were prepared by emulsification sonication-solvent evaporation...
Abstract Purpose Neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s are debilitating conditions resulting from a progressive degeneration of nerve cells that is attributed to oxidative stress. Given the role hydrogen sulphide (H 2 S), an endogenously produced signalling molecule involved in regulating stress, exogenous administration H S has been proposed potential treatment strategy. This research study investigation into mechanical properties microneedles loaded AP39 (a...
Although factors such as age, sex, diabetes, obesity and changes in certain laboratory investigations are important prognostic COVID-19 infection, these may not apply to all ethnic/racial groups. We hypothesized differences routine biochemistry haematology indices Caucasian a combined group of Black, Asian Minority Ethnic (BAME) patients who tested positive for died, compared survivors.We our hypothesis 445 (229 Caucasian, 216 BAME) admitted secondary care with proven whom standard were...
Hydrogen sulfide (H2S), a gaseous signalling molecule, is important in numerous physiological and pathophysiological processes. Despite its initial identification as an environmental toxin, H2S now well described essential molecule that finely balanced to maintain cellular functions, especially modulating mitochondrial activity. Mitochondria are responsible for the oxidation of safe elimination while maintaining biogenesis. mitochondria generates various reactive sulfur species could...
Oxidative stress (OS) resulting from imbalance in the generation of reactive oxygen species (ROS) and/or dysfunction antioxidant machinery, is a key mechanism associated with onset neurodegenerative disorders. Although molecular mechanisms are still elusive, disorders such as Alzheimer's and Parkinson's disease have been mitochondrial dysfunction. Recently, mitochondrial-targeted hydrogen sulphide (H2S) donor, AP39, has shown to promote cellular bioenergetics OS related scenarios. The aim...
Abstract Background The COVID-19 infection has impacted pregnancy outcomes; however, few studies have assessed the association between haematological parameters and virus-related neonatal outcomes. We hypothesised differences in routine haematology indices pregnant non-pregnant patients as well COVID-19-negative subjects observed outcomes all populations. Further, we tested if pattern identification population would facilitate prediction of neonates with a poor Apgar score. Methods our...
Abstract Background Magnetic resonance imaging (MRI) is the standard for evaluating perianal fistulae. Perianal fistula can be first manifestation of CD, and needs to differentiated from non-CD associated fistula. This study sought identify variations in MRI characteristics fistulas patients with without inflammatory bowel disease (IBD), considering potential implications treatment decisions. Methods was a single-center cross-sectional analysis who underwent pelvic assessment between January...
Background: Atrial fibrillation (AF) pathogenesis is strongly linked to inflammation, but the role of inflammatory biomarkers like myeloperoxidase (MPO) levels inconclusive. This meta-analysis conducted evaluate association with atrial onset or recurrence. Methods: We a literature search in Pubmed, Scopus, and Google Scholar for studies relevant predictors AF specifically MPO. A fixed-effects was performed pool unadjusted adjusted odds ratio effects across studies. Sensitivity analysis...
In this report, we describe a case of homozygous delta-beta (δβ) thalassaemia, rare genetic disorder characterized by severe deficiency in delta (δ) and beta (β)-globin chain production, leading to ineffective erythropoiesis chronic haemolytic anaemia. The patient, 26-year-old female with δβ-thalassaemia, experienced miscarriage. High-performance liquid chromatography revealed 89.5% foetal haemoglobin (HbF) 14.4% glycated HbF. Sebia capillary electrophoresis showed peak 97.2% 2.8%. Kleihauer...
Hypoxia, or insufficient oxygen availability is a common feature in the development of myriad cardiovascular-related conditions including ischemic disease. Hydrogen sulphide (H2S) donors, such as sodium thiosulphate (STS), are known for their cardioprotective properties. However, H2S due to its gaseous nature, released and cleared rapidly, limiting potential translation clinical settings. For first time, we developed characterised liposome formulations encapsulating STS explored modulating...
Considering the fact that only about 1 per cent of global water resources are available to humankind for drinking and other uses, issue scarcity gives renewed significance management. This article aims explore several socio-economic hence, planning issues related this highly significant environmental resource. Water management specifically have been looked at from a multi-dimensional view. highlights linkages between scarcity, food security agriculture. usage its impact on poverty...
Abstract Aims/hypothesis; Increased accumulation of senescent cells with ageing is associated reduced ability insulin-target tissues to utilise glucose, resulting in increased insulin resistance and glucotoxicity. We investigated the role senescent-associated secretory phenotype (SASP) within C2C12, skeletal muscle on glucose homeostasis if such effects can be reversed by blocking pro-inflammatory pathways. Methods; C2C12 myotubes were treated 40% conditioned media from fibroblasts. Indirect...