A5026217193- Palliative Care and End-of-Life Issues
- Geriatric Care and Nursing Homes
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Chronic Disease Management Strategies
- Patient-Provider Communication in Healthcare
- Family and Patient Care in Intensive Care Units
- PI3K/AKT/mTOR signaling in cancer
- Patient Dignity and Privacy
- Protein Interaction Studies and Fluorescence Analysis
- Cancer-related gene regulation
- Interprofessional Education and Collaboration
- Advancements in Transdermal Drug Delivery
- Alzheimer's disease research and treatments
- Childhood Cancer Survivors' Quality of Life
- Spectroscopy Techniques in Biomedical and Chemical Research
- Healthcare Systems and Technology
- Nutrition and Health in Aging
- HER2/EGFR in Cancer Research
- Wnt/β-catenin signaling in development and cancer
- Neurological diseases and metabolism
- Grief, Bereavement, and Mental Health
- Pharmaceutical Practices and Patient Outcomes
- Sulfur Compounds in Biology
- Mental Health and Psychiatry
University of Cambridge
2009-2025
Aston University
2021-2024
University College London
2012-2023
University of London
2023
University of Nottingham
2023
Cambridge School
2020
Addenbrooke's Hospital
2015
Compared with younger people, older people and those frailty are more likely to die from acute infections, such as covid-19, less survive intensive care. 1 2 This has prompted calls internationally for advance care planning in these vulnerable populations, focusing on documenting individuals' preferences resuscitation hospital admission. 3 4 We suggest that the benefits of derive its process than plans it produces, recognising this is essential provision optimum patients their...
A fundamental aspect of epithelial homeostasis is the dependence on specific growth factors for cell survival, yet underlying mechanisms remain obscure. We found an "inverse" mode receptor tyrosine kinase signaling that directly links ErbB inactivation to induction apoptosis. Upon ligand deprivation Mig6 dissociates from and binds activates c-Abl trigger p73-dependent apoptosis in mammary cells. Deletion Errfi1 (encoding Mig6) inhibition or RNAi silencing causes impaired luminal filling...
Abstract Purpose Neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s are debilitating conditions resulting from a progressive degeneration of nerve cells that is attributed to oxidative stress. Given the role hydrogen sulphide (H 2 S), an endogenously produced signalling molecule involved in regulating stress, exogenous administration H S has been proposed potential treatment strategy. This research study investigation into mechanical properties microneedles loaded AP39 (a...
Background The anticipatory prescribing of injectable medications is recommended practice in controlling distressing symptoms the last days life. A 2017 systematic review found and guidance was based on inadequate evidence. Since then, there has been considerable additional research, warranting a new review. Aim To evidence published since concerning for adults at end-of-life community, to inform guidance. Design Systematic narrative synthesis. Methods Nine literature databases were searched...
Background Increasing numbers of people die the frailty and multimorbidity associated with old age, often without receiving an end-of-life diagnosis. Compared to those a single life-limiting condition such as cancer, frail older are less likely access adequate community care. To address this inequality, guidance for professional providers health care encourages them make diagnoses more in people. These centre on prognosis, making difficult establish given inherent unpredictability...
<h3>Introduction</h3> Anticipatory prescribing (AP), the supply of injectable medication to a patient in advance need, is well-established practice UK although there currently limited evidence and guidance support best practice. With view developing guidance, we explored views healthcare professionals (HCPs) about areas need improvement AP. <h3>Methods</h3> Two day workshops were held London Cambridge, attended by 89 delegates. Participants completed an initial survey then participated two...
Background Serious illness is characterised by uncertainty, particularly in older age groups. Uncertainty may be experienced patients, family carers, and health professionals about a broad variety of issues. There are many evidence gaps regarding the experience management uncertainty. Aim We aimed to identify priority research areas concerning uncertainty serious illness, ensure that future better meets needs those affected reduce inefficiencies. Methods Rapid prioritisation workshop...
<h3>Background</h3> The anticipatory prescribing (AP) of injectable medications is a widely used and low-cost community end-of-life care intervention. It intended to aid symptom control prevent unnecessary delays in accessing medical assessments, prescriptions sourcing the medication when symptoms arise, especially during out-of-hours periods.<sup>1–4</sup> AP policies are often designed around outcome rather than reflecting lived experiences key stakeholders involved. <h3>Aim</h3>...
<h3>Background</h3> The anticipatory prescribing of injectable medications is recommended practice in controlling distressing symptoms the last days life. A 2017 systematic review found and guidance was based on inadequate evidence. Since then, evidence base has changed significantly, warranting a new review. <h3>Aim</h3> To published since concerning for adults at end life community. <h3>Methods</h3> <h3>Systematic narrative synthesis</h3> Nine literature databases were searched from May to...
Abstract Introduction National guidelines suggest that patients in the last year of life should be identified, their prognosis and future care options discussed, with advance planning (ACP) recorded. Goals-of-care discussed hospitalised at risk deteriorating or life-limiting conditions. The stated purpose ACP goals-of-care discussions is to increase goal-concordant (i.e. receiving treatments they would wish receive, not those want). This literature review investigates evidence-base for these...
Abstract Background Serious illness is characterised by uncertainty, particularly in older age groups. Uncertainty may be experienced patients, family carers, and health professionals about a broad variety of issues. There are many evidence gaps regarding the experience management uncertainty. Aim We aimed to identify priority research areas concerning uncertainty serious illness, ensure that future better meets needs those affected reduce inefficiencies. Methods Rapid prioritisation...
Abstract Introduction When a doctor is informed of patient’s future care preferences if they were to lose capacity, there an ethical and legal obligation share this information with the treating medical team. In frail older patients, conversations about treatment often occur during hospital admission. We sought assess communication these GP. Methods Retrospective chart review consecutive discharges from acute geriatric wards across seven hospitals. Records excluded patient was admitted for...
SH is supported by the Addenbrooke's Charitable Trust and Evelyn Trust. BB funded National Institute for Health Research (NIHR) School Primary Care Research. SB Applied Collaboration East of England.