A5020726566- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- COVID-19 Clinical Research Studies
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Palliative Care and End-of-Life Issues
- Long-Term Effects of COVID-19
- Coronary Artery Anomalies
- Infective Endocarditis Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Lipoproteins and Cardiovascular Health
- Inflammatory Biomarkers in Disease Prognosis
- Airway Management and Intubation Techniques
- Cardiovascular and Diving-Related Complications
Sinai Hospital
2016-2024
University of Louisville
2021-2024
Siksha O Anusandhan University
2024
Imperial College London
2024
Regional Centre for Biotechnology
2024
Narsee Monjee Institute of Management Studies
2024
University of Louisville Hospital
2023
Kingsley House
2022-2023
University of Alabama at Birmingham
2022
East Carolina University
2022
Background: As the pandemic of coronavirus disease 2019 (COVID-19) continues, prognostic markers are now being identified. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) easily accessible values that have been known to correlate with inflammation prognosis in several conditions. We used available data identify association NLR PLR severity COVID-19. Methods: A literature search using EMBASE, MEDLINE, Google Scholar for studies reporting use COVID-19 published until...
Matrix metalloproteinase-9 (MMP-9) cleaves various proteins to regulate inflammatory and injury responses. However, MMP-9's activities during influenza A viral (IAV) infections are incompletely understood. Herein, plasma MMP-9 levels were increased in patients with pandemic H1N1 seasonal IAV infections. lung localized airway epithelial cells leukocytes H1N1-infected WT murine lungs. Mmp-9-/- mice had lower mortality rates, reduced weight loss, titers, injury, along E-cadherin shedding...
Rationale: ADAM8 (a disintegrin and metalloproteinase domain-8) is expressed by leukocytes epithelial cells in health, but its contribution to the pathogenesis of chronic obstructive pulmonary disease (COPD) unknown.Objectives: To determine whether expression increased lungs patients with COPD cigarette smoke (CS)-exposed mice, promotes development COPD.Methods: levels were measured lung, sputum, plasma, and/or BAL fluid samples from COPD, smokers, nonsmokers, wild-type (WT) mice exposed CS...
Radiofrequency or ultrasound renal denervation (RDN) has shown conflicting results when used as an adjunctive option for hypertension management in randomized controlled trials (RCTs).We searched Pubmed, MEDLINE, and other online databases RCTs comparing RDN versus sham-control procedures patients with uncontrolled resistant hypertension. The endpoints of interest were 24-h ambulatory (AMB) blood pressure (BP), daytime AMB BP, office BP. We performed a random-effects meta-analysis using the...
Timely identification of palliative care needs can reduce hospitalizations and improve quality life. The Supportive & Palliative Care Indicators Tool (SPICT) identifies patients with advanced medical conditions who may need special planning. Rothman Index (RI) detects at high risk acutely decompensating in the inpatient setting. SPICT RI among cancer were utilized this study to evaluate their potential roles referrals.Advanced admitted an institution Baltimore, Maryland 2019 retrospectively...
Current guidelines recommend targeting a mean arterial pressure (MAP) goal of 65 mm Hg or more in critically ill medical patients. Prospective studies have shown that higher MAP can improve survival and decrease end-organ damage. However, randomized controlled trials (RCTs) failed to show similar results. Thus, we performed this meta-analysis evaluate whether high compared standard low will clinical outcomes patients.We searched electronic databases for RCTs comparing goals versus A was...
Vorapaxar specifically and effectively inhibits protease activated receptor-1 may reduce thrombin-mediated ischemic events without interfering primary hemostasis. In the TRA-2P-TIMI 50 trial, vorapaxar reduced risk of outcome but with increased bleeding risk. post hoc analysis, in patients a history myocardial infarction, peripheral artery disease, net clinical favored therapy 10% reduction cardiovascular death, stroke, urgent coronary revascularization moderate or severe bleeding. Based on...
BRASH syndrome is characterized by bradycardia, renal failure, AV nodal blockade, shock, and hyperkalemia. The proposed mechanism involves a vicious cycle between blockers, hyperkalemia, failure was first described in 2016. We present case of 52-year-old woman who presented with progressively worsening shortness breath hypertensive urgency subsequently developed profound bradycardia shock that refractory to resuscitative measures, she diagnosed syndrome. In this article, we explore the...