A5085264385- Schizophrenia research and treatment
- Mental Health and Psychiatry
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Bipolar Disorder and Treatment
- Attention Deficit Hyperactivity Disorder
- Mental Health Treatment and Access
- Mental Health Research Topics
- Obsessive-Compulsive Spectrum Disorders
- Psychosomatic Disorders and Their Treatments
- Treatment of Major Depression
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Family Caregiving in Mental Illness
- Neuroscience and Music Perception
- Neural and Behavioral Psychology Studies
- Tryptophan and brain disorders
- Advanced Neuroimaging Techniques and Applications
- Child Abuse and Trauma
- Electroconvulsive Therapy Studies
- Personality Disorders and Psychopathology
- Mental Health and Patient Involvement
- Memory and Neural Mechanisms
- Educational and Psychological Assessments
- Neurotransmitter Receptor Influence on Behavior
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Vestre Viken Hospital Trust
2015-2024
University of Oslo
2015-2024
Oslo University Hospital
1988-2017
Centre for Mental Health
2017
Stavanger University Hospital
2012-2016
University of Bergen
2000-2016
University of Stavanger
2012-2016
Diakonhjemmet Hospital
2015
Yale University
2004-2012
Region Zealand
2012
Most studies on first-episode psychosis show an association between a long duration of untreated (DUP) and poorer short-term outcome, but the mechanisms this relationship are poorly understood.To determine whether it is possible to reduce DUP for patients in defined health care area through introduction early detection (ED) program, compared with parallel areas without ED program (No-ED).We included consecutive DSM-IV diagnosis nonorganic, nonaffective coming their first treatment study...
Objective: Early detection in first-episode psychosis confers advantages for negative, cognitive, and depressive symptoms after 1, 2, 5 years, but longitudinal effects are unknown. The authors investigated the differences recovery 10 years between regional health care sectors with without a comprehensive program early of psychosis. Method: evaluated 281 patients (early detection, N=141) 18 to 65 old first episode nonaffective 1997 2001. Of these, 101 early-detection area 73 usual-detection...
Objective: The suicide rate in schizophrenia is high, with the risk being highest early course. of attempts before treatment onset also high and often event leading up to first contact. A previous report showed that duration untreated psychosis can be reduced through an detection program, reduction was associated lower symptom levels at initiation. Treatment programs bring first-episode patients into have potential reduce for attempts. Method: authors examined consecutive nonorganic,...
<h3>Background</h3> The duration of untreated psychosis (DUP)—the time from onset psychotic symptoms to the start adequate treatment—is consistently correlated with better course and outcome, but mechanisms are poorly understood. <h3>Objective</h3> To report effects reducing DUP on 2-year outcome. <h3>Design</h3> A total 281 patients a<i>DSM-IV</i>diagnosis nonorganic, nonaffective coming their first treatment during 4 consecutive years were recruited, which 231 participated in follow-up....
Depression is associated with impairment of cognitive functions, and especially executive functions (EFs). Despite the fact that most depressed patients experience recurrence episodes, pattern severity have not been well characterized in this group patients. We asked if to what extent these were impaired on a range neuropsychological tests measuring EFs, also when confounding factors adjusted for. Forty-five (aged 19–51 years) moderate severe (Hamilton score >18) recurrent major depressive...
OBJECTIVE: The authors examined the relationship of neurocognitive function with duration untreated psychosis, premorbid illness factors, and clinical symptoms to determine whether long psychosis independently compromises cognitive function. METHOD: Patients recruited a study effect an early detection program on first-episode in two catchment areas were compared patients similar treatment other without program. median was 10.5 weeks for all patients. A total 301 entered study, 207 completed...
Background During the last decades we have seen a new focus on early treatment of psychosis. Several reviews shown that duration untreated psychosis (DUP) is correlated to better outcome. However, it still unknown whether will lead long-term This study reports effects reducing DUP 5-year course and Method 1997–2000 total 281 consecutive patients aged >17 years with first episode non-affective were recruited, which 192 participated in follow-up. A comprehensive detection (ED) programme...
A substantial proportion of schizophrenia-spectrum patients exhibit a cognitive impairment at illness onset. However, the long-term course neurocognition and possible neurotoxic effect time spent in active psychosis, is topic controversy. Furthermore, it importance to find out what predicts neurocognition. Duration untreated psychosis (DUP), accumulated first year after start treatment, relapse rates symptoms are potential predictors course. In this study, 261 first-episode were assessed...
The MATRICS Consensus Cognitive Battery (MCCB) was developed for schizophrenia patients, but is also being used to assess neurocognitive function in bipolar disorder. This study aims describe differences major depressive disorder patients and healthy controls with the MCCB, relationship between depression symptom severity, subjective cognitive complaints, objective test performance. Thirty-three 33 pairwise matched were assessed MCCB. Montgomery-Åsberg Depression Rating Scale (MADRS)...
Abstract Introduction Regional gray matter (GM) alterations have been reported in early-onset psychosis (EOP, onset before age 18), but previous studies yielded conflicting results, likely due to small sample sizes and the different brain regions examined. In this study, we conducted a whole voxel-based morphometry (VBM) analysis large of individuals with EOP, using newly developed ENIGMA-VBM tool. Methods 15 independent cohorts from ENIGMA-EOP working group participated study. The overall...
The authors used functional magnetic resonance imaging (fMRI) to investigate brain activation in patients with schizophrenia and major depression while they performed two tasks-a vigilance task a mental arithmetic task-that differed cognitive complexity.In the task, participants had press response button whenever specific number was seen on screen inside MR scanner. In add consecutive numbers sum 10. fMRI 1.5-T Twelve recurrent nonpsychotic unipolar depression, 12 schizophrenia, healthy...
Knowledge about premorbid development in psychosis can shed light upon theories aetiology and schizophrenic heterogeneity, form a basis for early detection initiatives.To identify validate patterns of functioning first-episode psychosis.The Premorbid Adjustment Scale was used to examine 335 patients.Social academic function constituted fairly independent dimensions. Cluster analysis identified groups varying both level course. Patients with stable social course compared deteriorating one had...
Objective: The aim of the study is to investigate whether subjects with schizophrenia and major depression display attention deficits for different reasons. Method: Subjects ( n = 53), recurrent 50) normal controls were administered 11 measures processing speed, selective vigilance. Indices basal speeded attention, non‐speeded vigilance computed. Results: Both clinical groups impaired on all chronometric tests. schizophrenic also more compared speed. Only schizophrenics attention. Compared...
Early intervention is assumed to improve outcome in first-episode psychosis, but this has not been proven. Objective: To study whether 1-year will be better a health care sector with early detection (ED) of psychosis compared sectors no (no-ED). Design: quasi-experimental ED 2 experimental and no-ED control sectors. was achieved through low-threshold teams information campaigns about for the public, schools, primary providers. The areas offered an equivalent assessment treatment program...
Substance use is common in first-episode psychosis (FEP) and has been linked to poorer outcomes with more severe psychopathology higher relapse rates. Early substance discontinuation appears improve symptoms function. However, studies vary widely their methodology, few have examined patients longitudinally, making it difficult draw conclusions for practice treatment. We aimed investigate the relationship between early abstinence long-term course of illness a representative sample FEP...
Impaired neuropsychological performance involving abstraction-flexibility, memory, motor function, and attention has frequently been reported in schizophrenia as well deficit hyperactivity disorder (ADHD). This study represents an attempt to compare groups of adolescents with ADHD on a comprehensive test battery. Such comparison affords the opportunity ascertain differences degree, profile, specificity impairments.The 19 schizophrenia, 20 ADHD, 30 normal broad battery cognitive tests was...
The outcome of a psychoeducational treatment programme for very early‐onset schizophrenics was compared with standard reference treatment. study sample consisted 12 patients in each group. Clinical assessed by relapses during the 2‐year period and changes psychosocial functioning as measured Global Assessment Scale. A cost‐effectiveness analysis also carried out. results indicated that most effective relapse cheapest: programme. Patients poor premorbid benefit from this Decisive respect to...
Objective: To identify and discuss methodological pitfalls that may help explain why many questions around early detection (ED) duration of untreated psychosis (DUP) are still unsolved. Method: This paper concentrates on in the following areas: sampling, measurement data analyses. Results: The main problems seem to be: Sampling : Referral bias, exclusion patients, patient refusal, patients lost follow‐up. Measurement Reliability, which is particularly cogent for multisite investigations,...
Objective: To investigate the long‐term effects of a cognitive remediation programme for adolescents with early onset psychosis. Method: Twenty‐five subjects (cognitive remediation, n = 14; control, 11) were assessed on cognitive, clinical and psychosocial measures 1 year after discharge. All patients had received psychoeducational programme, while experimental group addition 30‐h programme. Results: A significant overall improvement eight 10 three four outcome was found. After controlling...