A5054422867- Muscle metabolism and nutrition
- Veterinary Equine Medical Research
- Hormonal and reproductive studies
- Virus-based gene therapy research
- Veterinary Pharmacology and Anesthesia
- Pharmacology and Obesity Treatment
- Biosimilars and Bioanalytical Methods
- CRISPR and Genetic Engineering
- Xenotransplantation and immune response
- Pharmacogenetics and Drug Metabolism
- Reproductive Physiology in Livestock
- Viral Infectious Diseases and Gene Expression in Insects
Omeprazole is a gastric acid secretion inhibitor used as an effective anti-ulcer drug. Based on oral administration studies, its International Screening Limit (ISL) was established in plasma and urine at 1 ng/mL with Detection Time (DT) of 48 h. A novel formulation injectable omeprazole has since been released, therefore, pharmacokinetic study performed to assess the DT above ISL against current advice. Six Thoroughbred horses were given four repeated weekly intramuscular administrations (4...
Oxandrolone is an anabolic-androgenic steroid with favourable anabolic to androgenic ratio, making it effective agent less side effects. Although its metabolism has been studied in humans, phase I and II not previously reported the horse. The purpose of this study was investigate vitro oxandrolone (using both equine liver microsomes S9) vivo following oral administration (three daily doses 50 mg a single Thoroughbred horse), using gas liquid chromatography-mass spectrometry techniques....
Abstract Calcium dobesilate (CD) is a synthetic venoactive drug used in veterinary medicine to treat equine navicular disease. Etamsylate haemostatic agent horses for the treatment of exercise‐induced pulmonary haemorrhage. Both etamsylate and CD dissociate circulatory system with 2,5‐HBSA as active drug. The aim research was be able provide detection time (DT) advice from pharmacokinetic (PK) studies Thoroughbred better inform trainers, their surgeons, prescribing these substances...
YK-11 is a steroidal selective androgen receptor modulator, compound class prohibited in both equine racing and human sports because of their potentially performance enhancing properties. easily accessible via internet-based supplement vendors making this possible candidate for doping; however, its phases I II metabolism has not yet been reported the horse. The purpose study was to investigate vivo metabolites urine plasma following oral administration with three daily doses 50 mg two...
Abstract Due to the ease of collection, transport and storage, use dried blood spots (DBS) offers an attractive alternative matrix for detection abuse gene therapy, otherwise known as doping. This study evaluated recovery, extraction efficiency resulting capability DNA from DBS by evaluating different target types, kits, number punches tube preservatives. The long‐term storage stability low‐copy‐number transgene targets in was not assessed this but would be noteworthy investigate further....