Background/Objectives: Some individuals with obesity may exhibit fewer metabolic disturbances and face a lower long-term risk of complications; however, the existence this so-called “metabolically healthy obesity” (MHO) compared to unhealthy (MUO) remains controversial. We hypothesized that children MHO might have more favorable profile than MUO. Markers glucose metabolism insulin sensitivity were between adolescents diagnosed Methods: This study recruited prospectively 104 (aged 6–16 years,...

Biofilm-related infections pose significant challenges in neonatal and pediatric care, contributing to increased morbidity mortality rates. These complex microbial communities, comprising bacteria fungi, exhibit resilience against antibiotics host immune responses. Bacterial species such as Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, epidermidis commonly form biofilms on medical devices, exacerbating infection risks. Neonates children, particularly those intensive...

.Neonatal sepsis is a major cause of morbidity and mortality in neonates. A particular concern the increasing prevalence antibiotic-resistant strains among Neonatal Intensive Care Units (NICUs). significant challenge context neonatal multi-drug resistant infections paucity therapeutic options, as majority newer antibiotics targeting these are not authorized for use Two novel beta-lactam/beta-lactamase inhibitors have recently been approved neonates with infections: ceftazidime/avibactam...

To investigate potential predictors that may be used in clinical practice to discriminate between permanent congenital hypothyroidism (PCH) and transient (TCH). A retrospective cohort study was conducted, enrolling neonates diagnosed with (CH) by neonatal screening test or blood testing due risk factors. The levothyroxine (LT4) dose thyroid stimulating hormone (TSH) levels of children from birth three years age were recorded. 88 enrolled, 35 PCH 53 TCH. Doses above 3.8μg/kg/d at 6 months...

Obesity is invariably accompanied by autonomic dysfunction, although data in pediatric populations are conflicting. We conducted a systematic review and meta-analysis of 12 studies (totaling 1102 participants) comparing obese normal-weight subjects (5-18 years age), defined as body mass index >95th or <85th percentile, respectively. Using random-effects model, we report the standardized mean differences (SMD) sympathetic vagal indices, calculated heart rate variability....

Neonatal sepsis is a leading cause of morbidity and mortality in neonates, particularly low middle-income countries. The emergence antimicrobial resistance rapidly growing global problem. A significant proportion the pathogens that commonly neonatal are resistant to multiple antibiotics. Therefore, for empirical treatment sepsis, repurposing older antibiotics effective against multidrug-resistant being investigated. This review aims provide an overview current research experience using...

Background: Obesity is invariably accompanied by autonomic dysfunction, although data in pediatric populations are conflicting. Methods: We conducted a systematic review and meta-analysis of 12 studies (totaling 1102 participants) comparing obese normal-weight subjects (5–18 years age), defined as body mass index >95th or <85th percentile, respectively. Using random-effects model, we report the standardized mean differences (SMD) sympathetic vagal indices heart rate variability....

Neonatal sepsis is a leading cause of morbidity and mortality in neonates, particularly low- middle-income countries. The emergence antimicrobial resistance rapidly growing global problem. A significant proportion the pathogens that commonly neonatal are resistant to multiple antibiotics. Therefore, for empirical treatment sepsis, repurposing older antibiotics effective against multidrug-resistant being investigated. This review aims provide an overview current research experience using...

Abstract Objective C-reactive protein (CRP) is one of the most extensively used biomarkers in investigation early-onset sepsis (EOS). Current evidence suggests normal kinetics serum CRP should be considered when evaluating infants for presumable EOS. The current study aimed to evaluate kinetics, and establish percentiles a cohort term near-term with no confirmed or clinical Methods We retrospectively reviewed medical records all neonates ≥34 weeks' gestation screened EOS, from January until...

Evidence examining the association of over-hydration during early life with hemodynamically significant patent ductus arteriosus (hsPDA) and other morbidities is limited. Our aim was to evaluate fluid overload first postnatal day hsPDA common neonatal such as bronchopulmonary dysplasia in preterm infants.

Neonatal sepsis is a leading cause of morbidity and mortality in neonates, particularly low middle-income countries. The emergence antimicrobial resistance rapidly growing global problem. A significant proportion the pathogens that commonly neonatal are resistant to multiple antibiotics. Therefore, for empirical treatment sepsis, repurposing older antibiotics effective against multidrug-resistant being investigated. This review aims provide an overview current research experience using...

The neonatal intensive care unit (NICU) population, especially low birth weight and critically ill neonates, is at risk of invasive Candida infections, which are associated with high mortality rates unfavorable long-term outcomes. timely initiation an appropriate antifungal treatment has been demonstrated to enhance the prognosis. Factors that should be considered in choice agent include causative strain, presence location deep tissue infection, previous use prophylaxis, implanted devices....

Background/Objectives: Some individuals with obesity may exhibit fewer metabolic disturbances and face a lower long-term risk of complications. However, the existence this so-called "metabolically healthy obesity" (MHO) compared to unhealthy (MUO) remains topic debate. The aim study was comparatively assess glucose metabolism insulin sensitivity markers between children adolescents diagnosed MHO MUO. Methods: This recruited prospectively 104 (aged 6–16 years, 47 boys)...